Biosystem‐Inspired Engineering of Nanozymes for Biomedical Applications

Advanced Materials, Год журнала: 2023, Номер 36(10)

Опубликована: Янв. 9, 2023

Abstract Nanozymes with intrinsic enzyme‐mimicking activities have shown great potential to become surrogates of natural enzymes in many fields by virtue their advantages high catalytic stability, ease functionalization, and low cost. However, due the lack predictable descriptors, most nanozymes reported past been obtained mainly through trial‐and‐error strategies, efficacy, substrate specificity, as well practical application effect under physiological conditions, are far inferior that enzymes. To optimize efficacies functions biomedical settings, recent studies introduced biosystem‐inspired strategies into nanozyme design. In this review, advances engineering leveraging refined structure enzymes, simulating behavior changes process, mimicking specific biological processes or living organisms, introduced. Furthermore, currently involved applications summarized. More importantly, current opportunities challenges design discussed. It is hoped based on bioinspired will be beneficial for constructing new generation broadening applications.

Язык: Английский

---

Cerium oxide nanoparticles with antioxidative neurorestoration for ischemic stroke

Biomaterials, Год журнала: 2022, Номер 291, С. 121904 - 121904

Опубликована: Ноя. 10, 2022

Язык: Английский

---

Traditional Chinese medicine active ingredients-based selenium nanoparticles regulate antioxidant selenoproteins for spinal cord injury treatment

Journal of Nanobiotechnology, Год журнала: 2022, Номер 20(1)

Опубликована: Июнь 14, 2022

As Traditional Chinese Medicine (TCM) drugs, Huangqi and Danshen are always applied in combination for spinal cord injury (SCI) treatment based on the compatibility theory of TCM. Astragalus Polysaccharidesis (APS) Tanshinone IIA (TSIIA) main active ingredients Danshen, they both possess neuroprotective effects through antioxidant activities. However, low solubility poor bioavailability have greatly limited their application. In recent years, selenium nanoparticles (SeNPs) drawn enormous attention as potential delivery carrier drugs.In this study, TCM ingredients-based SeNPs surface decorated with APS loaded TSIIA (TSIIA@SeNPs-APS) were successfully synthesized under guidance Such design improved benefits high stability, efficient highly therapeutic efficacy SCI illustrated by an improvement protective TSIIA. The vivo experiments indicated that TSIIA@SeNPs-APS displayed efficiency cellular uptake long retention time PC12 cells. Furthermore, had a satisfactory effect against oxidative stress-induced cytotoxicity cells inhibiting excessive reactive oxygen species (ROS) production, so to alleviate mitochondrial dysfunction reduce cell apoptosis S phase cycle arrest, finally promote survival. can protect neurons rats enhancing GSH-Px activity decreasing MDA content, which was possibly via metabolism SeCys2 regulating selenoproteins resist damage.TSIIA@SeNPs-APS exhibited promising anti-oxidation therapy SCI, paved way developing synergistic nanotechnology improve well establishing novel treatments stress-related diseases associated Se regulation.

Язык: Английский

---

A ferroptosis-targeting ceria anchored halloysite as orally drug delivery system for radiation colitis therapy

Nature Communications, Год журнала: 2023, Номер 14(1)

Опубликована: Авг. 22, 2023

Radiation colitis is the leading cause of diarrhea and hematochezia in pelvic radiotherapy patients. This work advances pathogenesis radiation from perspective ferroptosis. An oral Pickering emulsion stabilized with halloysite clay nanotubes to alleviate by inhibiting Ceria nanozyme grown situ on can scavenge reactive oxygen species, deferiprone was loaded into lumen relieve iron stress. These two strategies effectively inhibit lipid peroxidation rescue ferroptosis intestinal microenvironment. The play a critical role as either medicine colitis, nanocarrier that targets inflamed colon electrostatic adsorption, or an interfacial stabilizer for emulsions. ferroptosis-based strategy effective vitro vivo, providing prospective candidate protection via rational regulation specific oxidative

Язык: Английский

---

Antioxidant and Prooxidant Nanozymes: From Cellular Redox Regulation to Next‐Generation Therapeutics

Angewandte Chemie International Edition, Год журнала: 2023, Номер 62(33)

Опубликована: Апрель 21, 2023

Nanozymes, nanomaterials with enzyme-mimicking activity, have attracted tremendous interest in recent years owing to their ability replace natural enzymes various biomedical applications, such as biosensing, therapeutics, drug delivery, and bioimaging. In particular, the nanozymes capable of regulating cellular redox status by mimicking antioxidant mammalian cells are great therapeutic significance oxidative-stress-mediated disorders. As distinction physiological oxidative stress (oxidative eustress) pathological distress) occurs at a fine borderline, it is challenge design that can differentially sense two extremes cells, tissues organs mediate appropriate chemical reactions. this Review, we summarize advances development redox-active applications. We primarily highlight prooxidant disease model systems, cancer, neurodegeneration, cardiovascular diseases. The future perspectives emerging area research challenges associated applications described.

Язык: Английский

---

Translational Selenium Nanoparticles to Attenuate Allergic Dermatitis through Nrf2-Keap1-Driven Activation of Selenoproteins

ACS Nano, Год журнала: 2023, Номер 17(14), С. 14053 - 14068

Опубликована: Июль 10, 2023

Easy recurrence and strong treatment side effects significantly limit the clinical of allergic dermatitis. The human trace element selenium (Se) plays essential roles in redox regulation through incorporation into selenoproteins form 21st necessary amino acid selenocysteine, to participates pathogenesis intervention chronic inflammatory diseases. Therefore, based on safe elemental properties Se, we construct a facile-synthesis strategy for antiallergic nanoparticles (LET-SeNPs), scale up production by employing spray drying method with lactose (Lac-LET-SeNPs) or maltodextrin (Mal-LET-SeNPs) as encapsulation agents realizing larger longer storage time. As expected, these as-prepared LET-SeNPs could effectively activate Nrf2-Keap1 signaling pathway enhance expression antioxidative selenoprotein at mRNA protein levels, then inhibit mast cell activation achieve efficient activity. Interestingly, undergo metabolism seleno-amino acids promote biosynthesis selenoproteins, which suppress ROS-induced cyclooxygenase-2 (COX-2) MAPKs release histamine cytokines. Allergic mouse Macaca fascicularis models further confirm that increase Se content skin, decrease cells infiltration, finally exhibit high therapeutic Taken together, this study not only constructs facile large-scale synthesis translational nanomedicine break bottleneck problem nanomaterials but also sheds light its application allergies.

Язык: Английский

---

Bioactive Ceria Nanoenzymes Target Mitochondria in Reperfusion Injury to Treat Ischemic Stroke

ACS Nano, Год журнала: 2024, Номер unknown

Опубликована: Янв. 24, 2024

Overproduction of reactive oxygen species by damaged mitochondria after ischemia is a key factor in the subsequent cascade damage. Delivery therapeutic agents to neurons brain potentially promising targeted strategy for treatment ischemic stroke. In this study, we developed ceria nanoenzymes synergistic drug-carrying nanosystem targeting address multiple factors Each component works individually as well synergistically, resulting comprehensive therapy. Alleviation oxidative stress and modulation mitochondrial microenvironment into favorable state tolerance are combined restore bridging injuries. This work also revealed detailed mechanisms which proposed nanodelivery system protects brain, represents paradigm shift stroke treatment.

Язык: Английский

---

Using Cu‐Based Metal–Organic Framework as a Comprehensive and Powerful Antioxidant Nanozyme for Efficient Osteoarthritis Treatment

Advanced Science, Год журнала: 2024, Номер 11(13)

Опубликована: Янв. 26, 2024

Abstract Developing nanozymes with effective reactive oxygen species (ROS) scavenging ability is a promising approach for osteoarthritis (OA) treatment. Nonetheless, numerous lie in their relatively low antioxidant activity. In certain circumstances, some of these may even instigate ROS production to cause side effects. To address challenges, copper‐based metal–organic framework (Cu MOF) nanozyme designed and applied OA Cu MOF exhibits comprehensive powerful activities (i.e., SOD‐like, CAT‐like, •OH activities) while negligible pro‐oxidant (POD‐ OXD‐like activities). Collectively, more at various types than other Cu‐based antioxidants, such as commercial CuO single‐atom nanozyme. Density functional theory calculations also confirm the origin its outstanding enzyme‐like activities. vitro vivo results demonstrate that an excellent decrease intracellular levels relieve hypoxic microenvironment synovial macrophages. As result, can modulate polarization macrophages from pro‐inflammatory M1 anti‐inflammatory M2 subtype, inhibit degradation cartilage matrix efficient The biocompatibility protective properties make it valuable asset treating ROS‐related ailments beyond OA.

Язык: Английский

---

A Bioinspired Manganese‐Organic Framework Ameliorates Ischemic Stroke through its Intrinsic Nanozyme Activity and Upregulating Endogenous Antioxidant Enzymes

Advanced Science, Год журнала: 2023, Номер 10(20)

Опубликована: Май 2, 2023

Following stroke, oxidative stress induced by reactive oxygen species (ROS) aggravates neuronal damage and enlarges ischemic penumbra, which is devastating to stroke patients. Nanozyme-based antioxidants are emerging treat through scavenging excessive ROS. However, most of nanozymes cannot efficiently scavenge ROS in cytosol mitochondria, due low-uptake abilities neurons barriers organelle membranes, significantly limiting nanozymes' neuroprotective effects. To overcome this limitation, a manganese-organic framework modified with polydopamine (pDA-MNOF), capable not only mimicking catalytic activities natural SOD2's domain but also upregulating two endogenous antioxidant enzymes fabricated. With such dual anti-ROS effect, nanozyme robustly decreases cellular effectively protects them from ROS-induced injury. STAT-3 signaling found play vital role pDA-MNOF activating the enzymes, HO1 SOD2. In vivo treatment improves survival middle cerebral artery occlusion (MCAo) mice reducing infarct volume more importantly, promotes animal behavioral recovery. Further, activates vascular endothelial growth factor expression, downstream target STAT3 signaling, thus enhancing angiogenesis. Taken together, biochemical, cell-biological, animal-level data demonstrate potentiality as ROS-scavenging agent for treatment.

Язык: Английский

---

Biomedical potential of nanozymes: Harnessing redox enzyme mimicry for theranostic applications

Coordination Chemistry Reviews, Год журнала: 2024, Номер 517, С. 215937 - 215937

Опубликована: Июнь 15, 2024

Язык: Английский

---