International Journal of Nanomedicine,
Год журнала:
2023,
Номер
Volume 18, С. 1537 - 1560
Опубликована: Март 1, 2023
Abstract:
Diabetes
mellitus
(DM)
induced
wound
healing
impairment
remains
a
serious
health
problem
and
burden
on
the
clinical
obligation
for
high
amputation
rates.
Based
features
of
microenvironment,
biomaterials
loading
specific
drugs
can
benefit
diabetic
treatment.
Drug
delivery
systems
(DDSs)
carry
diverse
functional
substances
to
site.
Nano-drug
(NDDSs),
benefiting
from
their
related
nano
size,
overcome
limitations
conventional
DDSs
application
are
considered
as
developing
process
in
treatment
field.
Recently,
number
finely
designed
nanocarriers
efficiently
various
(bioactive
non-bioactive
factors)
have
emerged
circumvent
constraints
faced
by
traditional
DDSs.
This
review
describes
recent
advances
nano-drug
involved
mitigating
diabetes
mellitus-based
non-healing
wounds.
Keywords:
drug
system,
nanotechnology,
healing,
nanoparticles
Molecular Pharmaceutics,
Год журнала:
2023,
Номер
20(7), С. 3338 - 3355
Опубликована: Июнь 20, 2023
Oxygen
is
a
critical
factor
that
can
regulate
the
wound
healing
processes
such
as
skin
cell
proliferation,
granulation,
re-epithelialization,
angiogenesis,
and
tissue
regeneration.
However,
hypoxia,
common
occurrence
in
bed,
impede
normal
processes.
To
enhance
healing,
oxygenation
strategies
could
effectively
increase
oxygen
levels
are
effective.
The
present
review
summarizes
stages
role
of
hypoxia
overviews
current
to
incorporate
various
delivery
or
generating
materials
for
dressing,
including
catalase,
nanoenzyme,
hemoglobin,
calcium
peroxide,
perfluorocarbon-based
materials,
addition
photosynthetic
bacteria
hyperbaric
therapy.
Mechanism
action,
efficacy,
potential
benefits
drawbacks
these
dressings
also
discussed.
We
conclude
by
highlighting
importance
design
optimization
address
clinical
needs
improve
outcomes.
Advanced Healthcare Materials,
Год журнала:
2023,
Номер
13(4)
Опубликована: Ноя. 9, 2023
Diabetic
wounds
are
more
likely
to
develop
into
complex
and
severe
chronic
wounds.
The
objective
of
this
study
is
assess
a
reactive
oxygen
species
(ROS)-responsive
multifunctional
injectable
hydrogel
for
the
purpose
diabetic
wound
healing.
A
(HA@Cur@Ag)
successfully
synthesized
with
dual
antioxidant,
antibacterial,
anti-inflammatory
properties
by
crosslinking
thiol
hyaluronic
acid
(SH-HA)
disulfide-bonded
hyperbranched
polyethylene
glycol
(HB-PBHE)
through
Michael
addition;
while,
incorporating
curcumin
liposomes
silver
nanoparticles
(AgNPs).
HA@Cur@Ag
exhibits
favorable
biocompatibility,
degradability,
injectivity.
outcomes
in
vitro
vivo
experiments
demonstrate
that
can
effectively
be
loaded
release
liposomes,
as
well
ions,
thereby
facilitating
healing
multiple
mechanisms,
including
ROS
scavenging,
bactericidal
activity,
effects,
promotion
angiogenesis.
Transcriptome
sequencing
reveals
suppresses
activation
tumour
necrosis
factor
(TNF)/nuclear
κB
(NF-κB)
pathway
ameliorate
oxidative
stress
inflammation
These
findings
suggest
ROS-responsive
hydrogel,
which
possesses
ability
precisely
coordinate
integrate
intricate
biological
molecular
processes
involved
healing,
notable
potential
expediting
International Journal of Nanomedicine,
Год журнала:
2023,
Номер
Volume 18, С. 1537 - 1560
Опубликована: Март 1, 2023
Abstract:
Diabetes
mellitus
(DM)
induced
wound
healing
impairment
remains
a
serious
health
problem
and
burden
on
the
clinical
obligation
for
high
amputation
rates.
Based
features
of
microenvironment,
biomaterials
loading
specific
drugs
can
benefit
diabetic
treatment.
Drug
delivery
systems
(DDSs)
carry
diverse
functional
substances
to
site.
Nano-drug
(NDDSs),
benefiting
from
their
related
nano
size,
overcome
limitations
conventional
DDSs
application
are
considered
as
developing
process
in
treatment
field.
Recently,
number
finely
designed
nanocarriers
efficiently
various
(bioactive
non-bioactive
factors)
have
emerged
circumvent
constraints
faced
by
traditional
DDSs.
This
review
describes
recent
advances
nano-drug
involved
mitigating
diabetes
mellitus-based
non-healing
wounds.
Keywords:
drug
system,
nanotechnology,
healing,
nanoparticles
