Recent advances in conductive hydrogels: classifications, properties, and applications

Chemical Society Reviews, Год журнала: 2022, Номер 52(2), С. 473 - 509

Опубликована: Дек. 9, 2022

Hydrogel-based conductive materials for smart wearable devices have attracted increasing attention due to their excellent flexibility, versatility, and outstanding biocompatibility. This review presents the recent advances in multifunctional hydrogels electronic devices. First, with different components are discussed, including pure single network based on polymers, additional additives (i.e., nanoparticles, nanowires, nanosheets), double additives. Second, a variety of functionalities, self-healing, super toughness, self-growing, adhesive, anti-swelling, antibacterial, structural color, hydrophobic, anti-freezing, shape memory external stimulus responsiveness introduced detail. Third, applications flexible illustrated strain sensors, supercapacitors, touch panels, triboelectric nanogenerator, bioelectronic devices, robot). Next, current challenges facing summarized. Finally, an imaginative but reasonable outlook is given, which aims drive further development future.

Язык: Английский

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Bacterial Growth-Induced Tobramycin Smart Release Self-Healing Hydrogel for Pseudomonas aeruginosa-Infected Burn Wound Healing

ACS Nano, Год журнала: 2022, Номер 16(8), С. 13022 - 13036

Опубликована: Авг. 3, 2022

Burns are a common health problem worldwide and highly susceptible to bacterial infections that difficult handle with ordinary wound dressings. Therefore, burn repair is extremely challenging in clinical practice. Herein, series of self-healing hydrogels (QCS/OD/TOB/PPY@PDA) good electrical conductivity antioxidant activity were prepared on the basis quaternized chitosan (QCS), oxidized dextran (OD), tobramycin (TOB), polydopamine-coated polypyrrole nanowires (PPY@PDA NWs). These Schiff base cross-links between aminoglycoside antibiotic TOB OD enable be slowly released responsive pH. Interestingly, acidic substances during bacteria growth process can induce on-demand release TOB, avoiding abuse antibiotics. The antibacterial results showed QCS/OD/TOB/PPY@PDA9 hydrogel could kill high concentrations Pseudomonas aeruginosa (PA), Staphylococcus aureus, Escherichia coli short time bactericidal effect for up 11 days an agar plate diffusion experiment, while showing vivo activity. Excellent long-lasting properties make it suitable severely infected wounds. Furthermore, incorporation PPY@PDA endowed near-infrared (NIR) irradiation assisted drug-resistant bacteria, conductivity, Most importantly, PA-infected model, more effectively controlled inflammation levels promoted collagen deposition, vascular generation, earlier closure compared Tegaderm smart delivery advantageous bacterial-infected healing.

Язык: Английский

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Antibacterial adhesive self-healing hydrogels to promote diabetic wound healing

Acta Biomaterialia, Год журнала: 2022, Номер 146, С. 119 - 130

Опубликована: Апрель 25, 2022

Язык: Английский

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Anti‐inflammatory hydrogel dressings and skin wound healing

Clinical and Translational Medicine, Год журнала: 2022, Номер 12(11)

Опубликована: Ноя. 1, 2022

Abstract Hydrogels are promising and widely utilized in the biomedical field. In recent years, anti‐inflammatory function of hydrogel dressings has been significantly improved, addressing many clinical challenges presented ongoing endeavours to promote wound healing. Wound healing is a cascaded highly complex process, especially chronic wounds, such as diabetic severe burn which adverse endogenous or exogenous factors can interfere with inflammatory regulation, leading disruption process. Although insufficient inflammation uncommon, excessive infiltration an almost universal feature impedes histological repair predictable biological step chronological order. Therefore, resolving essential. past 5 extensive research conducted on address healing, specifically by efficiently scavenging free radicals, sequestering chemokines promoting M 1 ‐to‐M 2 polarization macrophages, thereby regulating this study, we introduced novel demonstrated innovative methods for their preparation application achieve enhanced addition, summarize most important properties required discuss our analysis potential yet be addressed.

Язык: Английский

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Bioinspired Injectable Self-Healing Hydrogel Sealant with Fault-Tolerant and Repeated Thermo-Responsive Adhesion for Sutureless Post-Wound-Closure and Wound Healing

Nano-Micro Letters, Год журнала: 2022, Номер 14(1)

Опубликована: Сен. 13, 2022

Hydrogels with multifunctionalities, including sufficient bonding strength, injectability and self-healing capacity, responsive-adhesive ability, fault-tolerant repeated tissue adhesion, are urgently demanded for invasive wound closure healing. Motivated by the adhesive mechanism of mussel brown algae, bioinspired dynamic bonds cross-linked multifunctional hydrogel is designed based on sodium alginate (SA), gelatin (GT) protocatechualdehyde, ferric ions added, sutureless post-wound-closure. The through Schiff base bond, catechol-Fe coordinate bond strong interaction between GT temperature-dependent phase transition SA, endows resulting mechanical strength efficient closure, reopened wounds. Moreover, properties endowed mispositioning to be removed/repositioned, which conducive adhesion adhesives during surgery. Besides, hydrogels present good biocompatibility, near-infrared-assisted photothermal antibacterial activity, antioxidation thermo-responsive reversible hemostatic effect. in vivo incision evaluation demonstrated their capability promote post-wound-closure healing incisions, indicating that developed dressing could serve as versatile sealant.

Язык: Английский

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Recent progress of antibacterial hydrogels in wound dressings

Materials Today Bio, Год журнала: 2023, Номер 19, С. 100582 - 100582

Опубликована: Фев. 16, 2023

Hydrogels are essential biomaterials due to their favorable biocompatibility, mechanical properties similar human soft tissue extracellular matrix, and repair properties. In skin wound repair, hydrogels with antibacterial functions especially suitable for dressing applications, so novel hydrogel dressings have attracted widespread attention, including the design of components, optimization preparation methods, strategies reduce bacterial resistance, etc. this review, we discuss fabrication challenges associated crosslinking methods chemistry materials. We investigated advantages limitations (antibacterial effects mechanisms) different components in achieve good properties, response stimuli such as light, sound, electricity resistance. Conclusively, provide a systematic summary findings (crosslinking methods) an outlook on long-lasting effects, broader spectrum, diversified forms, future development prospects field.

Язык: Английский

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Research advances in smart responsive-hydrogel dressings with potential clinical diabetic wound healing properties

Military Medical Research, Год журнала: 2023, Номер 10(1)

Опубликована: Авг. 22, 2023

The treatment of chronic and non-healing wounds in diabetic patients remains a major medical problem. Recent reports have shown that hydrogel wound dressings might be an effective strategy for treating due to their excellent hydrophilicity, good drug-loading ability sustained drug release properties. As typical example, hyaluronic acid dressing (Healoderm) has been demonstrated clinical trials improve wound-healing efficiency healing rates foot ulcers. However, the degradation behavior clinically-used cannot adjusted according microenvironment. Due intricacy wounds, antibiotics other medications are frequently combined with practice, although these easily hindered by hostile environment. In this case, scientists created responsive-hydrogel based on microenvironment features (such as high glucose low pH) or external stimuli light magnetic field) achieve controllable release, gel degradation, improvements order overcome issues. These anticipated play significant role therapeutic dressings. Here, we review recent advances towards healing, focus structure design, principle responsiveness, degradation. Last but not least, advantages limitations responsive-hydrogels applications will also discussed. We hope contribute furthering progress hydrogels improved practical application.

Язык: Английский

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Structural and Functional Design of Electrospun Nanofibers for Hemostasis and Wound Healing

Advanced Fiber Materials, Год журнала: 2022, Номер 4(5), С. 1027 - 1057

Опубликована: Июнь 30, 2022

Язык: Английский

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Supramolecular Thermo‐Contracting Adhesive Hydrogel with Self‐Removability Simultaneously Enhancing Noninvasive Wound Closure and MRSA‐Infected Wound Healing

Advanced Healthcare Materials, Год журнала: 2022, Номер 11(13)

Опубликована: Апрель 15, 2022

Conventional wound closure and dressing are two crucial, time-consuming but isolated principles in care. Even though tissue adhesive opens a new era for closure, the method biomaterial that can simultaneously achieve noninvasive promote healing highly appreciated. Herein, novel supramolecular poly(N-isopropylacrylamide) hybrid hydrogel composed of quaternized chitosan-graft-β-cyclodextrin, adenine, polypyrrole nanotubes via host-guest interaction hydrogen bonds is developed. The demonstrates thermal contraction 47% remaining area after 2 h at 37 ℃ adhesion 5.74 kPa, which essential multiple mechanical biological properties including suitable properties, self-healing, on-demand removal, antioxidant, hemostasis, photothermal/intrinsic antibacterial activity (higher 99% killing ratio within 5 min irradiation). In both full-thickness skin incision excision models, reveals significant 24 post-surgery. acute methicillin-resistant Staphylococcus aureus-infected assays, wounds treated with demonstrate enhanced rapid rate, mild inflammatory response, advanced angiogenesis, well-arranged collagen fibers. Altogether, results indicate promising synchronously healing.

Язык: Английский

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Multiple Stimuli‐Responsive Nanozyme‐Based Cryogels with Controlled NO Release as Self‐Adaptive Wound Dressing for Infected Wound Healing

Advanced Functional Materials, Год журнала: 2023, Номер 33(31)

Опубликована: Апрель 23, 2023

Abstract Wound with drug‐resistant bacterial infections has become a serious challenge for the healthcare system, and designing wound dressing to self‐adapt need of different stage healing remains challenging. Herein, self‐adaptive dressings multiple stimuli‐responsiveness antibacterial activity are developed. Specifically, MoS 2 carrying reactive oxygen species (ROS) responsive nitric oxide (NO) release precursor L‐arginine (MSPA) is designed incorporated into carboxymethyl chitosan/ poly( N‐isopropylacrylamide) based cryogels (CMCS/PNIPAM) responsiveness (pH, near infrared (NIR), temperature) form that adapt therapeutic needs stages in infected healing. In response slightly acidic environment infection, assist capture capacity through acid‐triggered protonation behavior, effectively enhance photodynamic efficiency. Controllable on‐demand delivery ROS, NO, remote management biofluid achieved NIR light as trigger switch. The stimuli‐responsive nanozyme‐based efficiently eliminate MRSA biofilm NO assisted photodynamicand photothermal therapy (PDT&PTT). enzyme‐like activities relieved oxidative damage. Notably, these reduce alleviated stress, accelerate collagen deposition angiogenesis wounds, indicating provide new ideas treatment.

Язык: Английский

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