Biomaterials Science,
Год журнала:
2022,
Номер
10(15), С. 4058 - 4076
Опубликована: Янв. 1, 2022
Multifunctional
wound
dressings
or
smart
with
pro-angiogenic
function,
antibacterial
properties,
anti-inflammatory/antioxidant
activity
and
tissue
adhesion
for
chronic
repair.
Chemical Society Reviews,
Год журнала:
2022,
Номер
52(2), С. 473 - 509
Опубликована: Дек. 9, 2022
Hydrogel-based
conductive
materials
for
smart
wearable
devices
have
attracted
increasing
attention
due
to
their
excellent
flexibility,
versatility,
and
outstanding
biocompatibility.
This
review
presents
the
recent
advances
in
multifunctional
hydrogels
electronic
devices.
First,
with
different
components
are
discussed,
including
pure
single
network
based
on
polymers,
additional
additives
(i.e.,
nanoparticles,
nanowires,
nanosheets),
double
additives.
Second,
a
variety
of
functionalities,
self-healing,
super
toughness,
self-growing,
adhesive,
anti-swelling,
antibacterial,
structural
color,
hydrophobic,
anti-freezing,
shape
memory
external
stimulus
responsiveness
introduced
detail.
Third,
applications
flexible
illustrated
strain
sensors,
supercapacitors,
touch
panels,
triboelectric
nanogenerator,
bioelectronic
devices,
robot).
Next,
current
challenges
facing
summarized.
Finally,
an
imaginative
but
reasonable
outlook
is
given,
which
aims
drive
further
development
future.
ACS Nano,
Год журнала:
2022,
Номер
16(8), С. 13022 - 13036
Опубликована: Авг. 3, 2022
Burns
are
a
common
health
problem
worldwide
and
highly
susceptible
to
bacterial
infections
that
difficult
handle
with
ordinary
wound
dressings.
Therefore,
burn
repair
is
extremely
challenging
in
clinical
practice.
Herein,
series
of
self-healing
hydrogels
(QCS/OD/TOB/PPY@PDA)
good
electrical
conductivity
antioxidant
activity
were
prepared
on
the
basis
quaternized
chitosan
(QCS),
oxidized
dextran
(OD),
tobramycin
(TOB),
polydopamine-coated
polypyrrole
nanowires
(PPY@PDA
NWs).
These
Schiff
base
cross-links
between
aminoglycoside
antibiotic
TOB
OD
enable
be
slowly
released
responsive
pH.
Interestingly,
acidic
substances
during
bacteria
growth
process
can
induce
on-demand
release
TOB,
avoiding
abuse
antibiotics.
The
antibacterial
results
showed
QCS/OD/TOB/PPY@PDA9
hydrogel
could
kill
high
concentrations
Pseudomonas
aeruginosa
(PA),
Staphylococcus
aureus,
Escherichia
coli
short
time
bactericidal
effect
for
up
11
days
an
agar
plate
diffusion
experiment,
while
showing
vivo
activity.
Excellent
long-lasting
properties
make
it
suitable
severely
infected
wounds.
Furthermore,
incorporation
PPY@PDA
endowed
near-infrared
(NIR)
irradiation
assisted
drug-resistant
bacteria,
conductivity,
Most
importantly,
PA-infected
model,
more
effectively
controlled
inflammation
levels
promoted
collagen
deposition,
vascular
generation,
earlier
closure
compared
Tegaderm
smart
delivery
advantageous
bacterial-infected
healing.
Clinical and Translational Medicine,
Год журнала:
2022,
Номер
12(11)
Опубликована: Ноя. 1, 2022
Abstract
Hydrogels
are
promising
and
widely
utilized
in
the
biomedical
field.
In
recent
years,
anti‐inflammatory
function
of
hydrogel
dressings
has
been
significantly
improved,
addressing
many
clinical
challenges
presented
ongoing
endeavours
to
promote
wound
healing.
Wound
healing
is
a
cascaded
highly
complex
process,
especially
chronic
wounds,
such
as
diabetic
severe
burn
which
adverse
endogenous
or
exogenous
factors
can
interfere
with
inflammatory
regulation,
leading
disruption
process.
Although
insufficient
inflammation
uncommon,
excessive
infiltration
an
almost
universal
feature
impedes
histological
repair
predictable
biological
step
chronological
order.
Therefore,
resolving
essential.
past
5
extensive
research
conducted
on
address
healing,
specifically
by
efficiently
scavenging
free
radicals,
sequestering
chemokines
promoting
M
1
‐to‐M
2
polarization
macrophages,
thereby
regulating
this
study,
we
introduced
novel
demonstrated
innovative
methods
for
their
preparation
application
achieve
enhanced
addition,
summarize
most
important
properties
required
discuss
our
analysis
potential
yet
be
addressed.
Nano-Micro Letters,
Год журнала:
2022,
Номер
14(1)
Опубликована: Сен. 13, 2022
Hydrogels
with
multifunctionalities,
including
sufficient
bonding
strength,
injectability
and
self-healing
capacity,
responsive-adhesive
ability,
fault-tolerant
repeated
tissue
adhesion,
are
urgently
demanded
for
invasive
wound
closure
healing.
Motivated
by
the
adhesive
mechanism
of
mussel
brown
algae,
bioinspired
dynamic
bonds
cross-linked
multifunctional
hydrogel
is
designed
based
on
sodium
alginate
(SA),
gelatin
(GT)
protocatechualdehyde,
ferric
ions
added,
sutureless
post-wound-closure.
The
through
Schiff
base
bond,
catechol-Fe
coordinate
bond
strong
interaction
between
GT
temperature-dependent
phase
transition
SA,
endows
resulting
mechanical
strength
efficient
closure,
reopened
wounds.
Moreover,
properties
endowed
mispositioning
to
be
removed/repositioned,
which
conducive
adhesion
adhesives
during
surgery.
Besides,
hydrogels
present
good
biocompatibility,
near-infrared-assisted
photothermal
antibacterial
activity,
antioxidation
thermo-responsive
reversible
hemostatic
effect.
in
vivo
incision
evaluation
demonstrated
their
capability
promote
post-wound-closure
healing
incisions,
indicating
that
developed
dressing
could
serve
as
versatile
sealant.
Materials Today Bio,
Год журнала:
2023,
Номер
19, С. 100582 - 100582
Опубликована: Фев. 16, 2023
Hydrogels
are
essential
biomaterials
due
to
their
favorable
biocompatibility,
mechanical
properties
similar
human
soft
tissue
extracellular
matrix,
and
repair
properties.
In
skin
wound
repair,
hydrogels
with
antibacterial
functions
especially
suitable
for
dressing
applications,
so
novel
hydrogel
dressings
have
attracted
widespread
attention,
including
the
design
of
components,
optimization
preparation
methods,
strategies
reduce
bacterial
resistance,
etc.
this
review,
we
discuss
fabrication
challenges
associated
crosslinking
methods
chemistry
materials.
We
investigated
advantages
limitations
(antibacterial
effects
mechanisms)
different
components
in
achieve
good
properties,
response
stimuli
such
as
light,
sound,
electricity
resistance.
Conclusively,
provide
a
systematic
summary
findings
(crosslinking
methods)
an
outlook
on
long-lasting
effects,
broader
spectrum,
diversified
forms,
future
development
prospects
field.
Military Medical Research,
Год журнала:
2023,
Номер
10(1)
Опубликована: Авг. 22, 2023
The
treatment
of
chronic
and
non-healing
wounds
in
diabetic
patients
remains
a
major
medical
problem.
Recent
reports
have
shown
that
hydrogel
wound
dressings
might
be
an
effective
strategy
for
treating
due
to
their
excellent
hydrophilicity,
good
drug-loading
ability
sustained
drug
release
properties.
As
typical
example,
hyaluronic
acid
dressing
(Healoderm)
has
been
demonstrated
clinical
trials
improve
wound-healing
efficiency
healing
rates
foot
ulcers.
However,
the
degradation
behavior
clinically-used
cannot
adjusted
according
microenvironment.
Due
intricacy
wounds,
antibiotics
other
medications
are
frequently
combined
with
practice,
although
these
easily
hindered
by
hostile
environment.
In
this
case,
scientists
created
responsive-hydrogel
based
on
microenvironment
features
(such
as
high
glucose
low
pH)
or
external
stimuli
light
magnetic
field)
achieve
controllable
release,
gel
degradation,
improvements
order
overcome
issues.
These
anticipated
play
significant
role
therapeutic
dressings.
Here,
we
review
recent
advances
towards
healing,
focus
structure
design,
principle
responsiveness,
degradation.
Last
but
not
least,
advantages
limitations
responsive-hydrogels
applications
will
also
discussed.
We
hope
contribute
furthering
progress
hydrogels
improved
practical
application.
Advanced Healthcare Materials,
Год журнала:
2022,
Номер
11(13)
Опубликована: Апрель 15, 2022
Conventional
wound
closure
and
dressing
are
two
crucial,
time-consuming
but
isolated
principles
in
care.
Even
though
tissue
adhesive
opens
a
new
era
for
closure,
the
method
biomaterial
that
can
simultaneously
achieve
noninvasive
promote
healing
highly
appreciated.
Herein,
novel
supramolecular
poly(N-isopropylacrylamide)
hybrid
hydrogel
composed
of
quaternized
chitosan-graft-β-cyclodextrin,
adenine,
polypyrrole
nanotubes
via
host-guest
interaction
hydrogen
bonds
is
developed.
The
demonstrates
thermal
contraction
47%
remaining
area
after
2
h
at
37
℃
adhesion
5.74
kPa,
which
essential
multiple
mechanical
biological
properties
including
suitable
properties,
self-healing,
on-demand
removal,
antioxidant,
hemostasis,
photothermal/intrinsic
antibacterial
activity
(higher
99%
killing
ratio
within
5
min
irradiation).
In
both
full-thickness
skin
incision
excision
models,
reveals
significant
24
post-surgery.
acute
methicillin-resistant
Staphylococcus
aureus-infected
assays,
wounds
treated
with
demonstrate
enhanced
rapid
rate,
mild
inflammatory
response,
advanced
angiogenesis,
well-arranged
collagen
fibers.
Altogether,
results
indicate
promising
synchronously
healing.
Advanced Functional Materials,
Год журнала:
2023,
Номер
33(31)
Опубликована: Апрель 23, 2023
Abstract
Wound
with
drug‐resistant
bacterial
infections
has
become
a
serious
challenge
for
the
healthcare
system,
and
designing
wound
dressing
to
self‐adapt
need
of
different
stage
healing
remains
challenging.
Herein,
self‐adaptive
dressings
multiple
stimuli‐responsiveness
antibacterial
activity
are
developed.
Specifically,
MoS
2
carrying
reactive
oxygen
species
(ROS)
responsive
nitric
oxide
(NO)
release
precursor
L‐arginine
(MSPA)
is
designed
incorporated
into
carboxymethyl
chitosan/
poly(
N‐isopropylacrylamide)
based
cryogels
(CMCS/PNIPAM)
responsiveness
(pH,
near
infrared
(NIR),
temperature)
form
that
adapt
therapeutic
needs
stages
in
infected
healing.
In
response
slightly
acidic
environment
infection,
assist
capture
capacity
through
acid‐triggered
protonation
behavior,
effectively
enhance
photodynamic
efficiency.
Controllable
on‐demand
delivery
ROS,
NO,
remote
management
biofluid
achieved
NIR
light
as
trigger
switch.
The
stimuli‐responsive
nanozyme‐based
efficiently
eliminate
MRSA
biofilm
NO
assisted
photodynamicand
photothermal
therapy
(PDT&PTT).
enzyme‐like
activities
relieved
oxidative
damage.
Notably,
these
reduce
alleviated
stress,
accelerate
collagen
deposition
angiogenesis
wounds,
indicating
provide
new
ideas
treatment.