Hierarchical Self‐Assembly of Short Peptides: Nanostructure Formation, Function Tailoring, and Applications

Macromolecular Bioscience, Год журнала: 2025, Номер unknown

Опубликована: Янв. 31, 2025

This article explores the hierarchical self-assembly of short peptides, which refers to structured spatial arrangements these molecules over long distances. phenomenon is commonly found in nature and has important implications for biological structure function. Short peptides are preferred because they have ability spontaneously create various nanostructures. process, known as bottom-up assembly, allows addition functional groups at carboxyl or amine ends peptides. These enable specific functions that extremely valuable fields biotechnology biomedicine. text discusses basic processes involved such characteristics amino acid side chains, categorization according their chemical structure, influence intermolecular forces, dynamic process. In addition, paper uses disciplines biomedicine optoelectronics, including stimulus-responsive hydrogels, tissue engineering, drug delivery. The also suggests rational design principles controlling creating new commercial applications, particularly with offers insights into future discipline.

Язык: Английский

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Mesoscopic Simulation on Self-assembly of Diphenylalanine-based Analogue with Ethylenediamine Linker

Chinese Journal of Polymer Science, Год журнала: 2025, Номер unknown

Опубликована: Март 11, 2025

Язык: Английский

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Synergistic copper single sites and nanoparticles nano-trapped in hydrothermally treated Panax pseudo-ginseng for efficient CO2 transformation

Journal of environmental chemical engineering, Год журнала: 2025, Номер unknown, С. 116570 - 116570

Опубликована: Апрель 1, 2025

Язык: Английский

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Self‐Assembled Fluorescent Peptide Nanoprobes for Disease Diagnosis

Small Methods, Год журнала: 2025, Номер unknown

Опубликована: Июнь 1, 2025

Abstract Benefiting from the advantages of simple reactions, low energy consumption, and uniform properties, self‐assembly has been widely utilized for preparation nanoprobes. Peptides have chosen as “bricks” self‐assembling nano‐biomaterials due to their easy drug formation, highly variable sequence, good biocompatibility biodegradability. can efficiently self‐assemble through noncovalent interactions, such hydrogen bonding, electrostatic π–π stacking, hydrophobic van der Waals forces. Based on this, many ex situ in strategies are developed. The former self‐assembles into stable nanomaterials beforehand, while latter undergoes at target site response its specific stimulus‐responsive modules. As probe sizes miniaturized nanometer scale, they gain high sensitivity, detection limits, capability detection. Nanoprobes created self‐assembly, usually possess targeted accumulation tissues, prolonged elimination half‐life, multimodal imaging capabilities, making them effective disease diagnosis. This review introduces types self‐assembled fluorescent peptide nanoprobes according source fluorescence properties summarizes progress application diagnosis, cancer, neurodegenerative disease, bacterial infection. In addition, limitations will be discussed, new proposed development advanced peptide‐based nanoprobes, aimed improving potential clinical translation.

Язык: Английский

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Stereocomplex Nanocomposite Switch Based on Dynamic Helical Polymer-Gold and Silver Nanoparticle Hybrid Materials

Chemistry of Materials, Год журнала: 2023, Номер 35(12), С. 4865 - 4872

Опубликована: Июнь 9, 2023

Controlled ON/OFF stereocomplexation of dynamic helical polymer-metal nanoparticle nanocomposites─poly(phenylacetylene)-MNP nanocomposites (M = Au or Ag)─is presented. These novel hybrid materials can be found either as well-dispersed metal nanoparticles (MNPs) (stereocomplex OFF) fiber-like aggregates ON) with the distributed along material. A stereocomplex-MNP nanocomposite is formed by interaction two complementary and enantiomeric polymer-MNP [Poly-(R)-1-M1NPs/poly(S)-1-M2NPs (M1 M2 M1 ≠ M2; M Au, Ag)]. Interestingly, using polymers, i.e., poly(phenylacetylene)s (PPAs), coating agents nanoparticles, it possible to tune secondary structure polymer─elongation and/or compression─a fact that trigger formation/disruption stereocomplex. Moreover, these controlled in a reversible way (ON/OFF) playing supramolecular interactions keep helices together, such hydrogen bonds.

Язык: Английский

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Precise Modulation of Circularly Polarized Luminescence via Polymer Chiral Co‐assembly and Contactless Dynamic Chiral Communication

Angewandte Chemie, Год журнала: 2024, Номер 136(17)

Опубликована: Март 8, 2024

Abstract Circularly polarized luminescence (CPL) plays a pivotal role in cutting‐edge display and information technologies. Currently achieving precise color control dynamic signal regulation CPL still remains challenging due to the elusory relationship between fluorescence chirality. Inspired by natural mechanisms governing formation chiral interaction, we proposed an addition‐subtraction principle theory address this issue. Three fluorene‐based polymers synthesized Suzuki polycondensation with different electron‐deficient monomers exhibit similar structures UV/Vis absorption, but distinct emissions intramolecular charge transfer. Based on this, precise‐color CPL‐active films are obtained through quantitative supramolecular co‐assembly directed addition . Particularly, ideal white‐emitting film (CIE coordinates: (0.33, 0.33)) is facilely fabricated high quantum yield of 80.8 % dissymmetry factor ( g lum ) 1.4×10 −2 Structural analysis reveals that ordered stacking orientation favors higher Furthermore, dynamically regulated challenge, comparable subtraction proposed, involving contactless communication excited ground states. The representative system consisting as‐prepared chirality‐selective absorption azobenzene (Azo)‐containing constructed, weakening, reversal, enhancement. Finally, switchable quick response code realized based trans ‐ cis isomerization Azo moiety.

Язык: Английский

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Rapid and Green Fabrication of Nanozyme with Geminal CuN₃O Configuration for Efficient Catecholase‐Mimicking

Small, Год журнала: 2024, Номер 20(35)

Опубликована: Апрель 30, 2024

Fabrication of nanozyme with catecholase-like catalytic activity faces the great challenge merging outstanding low cost as well simple, rapid, and low-energy-consumed production, restricting its industrial applications. Herein, an inexpensive yet robust (i.e., DT-Cu) via simple one-step coordination between diaminotriazole (DT) CuSO

Язык: Английский

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Copper‐Induced Supramolecular Peptide Assemblies for Multi‐pathway Cell Death and Tumor Inhibition

Angewandte Chemie, Год журнала: 2024, Номер 136(34)

Опубликована: Июнь 5, 2024

Abstract Although self‐assembly has emerged as an effective tool for fabricating biomaterials, achieving precise control over the morphologies and functionalities of resultant assemblies remains ongoing challenge. Inspired by copper peptide naturally present in human plasma, this study, we designed a synthetic precursor, FcGH. FcGH can self‐assemble via two distinct pathways: spontaneous Cu 2+ ‐induced. These assembly pathways enabled formation with tunable adjusting amount added . We found that nanoparticles formed ‐induced exhibited significantly higher cellular uptake efficiency than wormlike fibers spontaneously. Moreover, process occurred spontaneously at 1 : molar ratio to FcGH, avoiding excessive use tedious preparation procedure. By co‐assembling 10‐hydroxycamptothecin (HCPT)‐conjugated supramolecular nanodrugs elicited multiple cell death modalities cancer cells elevated immunogenicity, enhancing therapeutic effect compared free HCPT. This study highlights efficient directing synergistic tumor therapy.

Язык: Английский

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Coordination-Induced Self-Assembly of a Dipeptide into Multifunctional Chiral Nanostructures

Langmuir, Год журнала: 2022, Номер 38(46), С. 14261 - 14268

Опубликована: Ноя. 11, 2022

Short peptides could be used as chiral motifs to self-assemble into various artificial nanostructures with supramolecular or nanoscale chirality, but their applications still need expanded. Here, under the mediation of metal ions, ferrocene–diphenylalanine (Fc-LFLF) peptide can nanostructures, including right-handed helical microflowers mediated by Cu2+, left-handed nanofibers Ag+, and Zn2+ Cd2+. Meanwhile, gold nanoparticles mineralized deposited on Cu2+/Fc-LFLF form AuNPs@Cu2+/Fc-LFLF, which showed significantly improved catalytic activity. The Ag+ further AgNPs@Fc-LFLF, showing an excellent antibacterial effect. Overall, this study provides new insights self-assembly short demonstrates that peptide–metal assemblies may have broad prospects in fields biocatalysis antimicrobials.

Язык: Английский

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Phenylalanine-based fibrillar systems

Chemical Communications, Год журнала: 2023, Номер 59(98), С. 14509 - 14523

Опубликована: Янв. 1, 2023

Phenylketonuria (PKU) is an inborn metabolic disorder characterized by excess accumulation of phenylalanine (Phe) and its fibril formation, resulting in progressive intellectual disability. Several research groups have approached from various directions to understand the formation toxic amyloid fibrils essential amino acid Phe. Different parameters like nature solvent, pH, Phe concentration, temperature, etc. influence kinetics. In this article, we summarized all major findings regarding Phe-based aqueous organic media discussed how non-covalent interactions are involved self-assembly process using spectroscopic microscopic techniques. The toxicity compared with other neurodegenerative peptides. It noted that can also induce globular proteins into fibrils. Later, discuss different approaches inhibit reduce toxicity. presence polyphenolic compounds, drugs, acids, nanoparticles, metal ions, crown ethers, others showed a remarkable inhibitory effect on formation. To best our knowledge, first-ever etymological analysis Phe-fibrillar system inhibition create strong database against PKU.

Язык: Английский

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