Abstract
Surgical
resection
remains
the
mainstream
treatment
for
malignant
melanoma.
However,
challenges
in
wound
healing
and
residual
tumor
metastasis
pose
significant
hurdles,
resulting
high
recurrence
rates
patients.
Herein,
a
bioactive
injectable
hydrogel
(BG‐Mn
gel
)
formed
by
crosslinking
sodium
alginate
(SA)
with
manganese‐doped
glass
(BG‐Mn)
is
developed
as
versatile
platform
anti‐tumor
immunotherapy
postoperative
The
incorporation
of
Mn
2+
within
(BG)
can
activate
cGAS‐STING
immune
pathway
to
elicit
robust
response
cancer
immunotherapy.
Furthermore,
doping
BG
endows
system
excellent
photothermal
properties,
hence
facilitating
STING
activation
reversing
immune‐suppressive
microenvironment.
exhibits
favorable
angiogenic
capacity
tissue
regenerative
potential,
promotes
cell
migration
vitro.
When
combining
BG‐Mn
anti‐PD‐1
antibody
(α‐PD‐1)
melanoma,
it
shows
enhanced
long‐term
memory
response.
Remarkably,
upregulate
expression
genes
related
blood
vessel
formation
promote
skin
regeneration
when
treating
full‐thickness
wounds.
Overall,
Gel
serves
an
effective
adjuvant
therapy
regulate
Materials Today Bio,
Год журнала:
2023,
Номер
19, С. 100582 - 100582
Опубликована: Фев. 16, 2023
Hydrogels
are
essential
biomaterials
due
to
their
favorable
biocompatibility,
mechanical
properties
similar
human
soft
tissue
extracellular
matrix,
and
repair
properties.
In
skin
wound
repair,
hydrogels
with
antibacterial
functions
especially
suitable
for
dressing
applications,
so
novel
hydrogel
dressings
have
attracted
widespread
attention,
including
the
design
of
components,
optimization
preparation
methods,
strategies
reduce
bacterial
resistance,
etc.
this
review,
we
discuss
fabrication
challenges
associated
crosslinking
methods
chemistry
materials.
We
investigated
advantages
limitations
(antibacterial
effects
mechanisms)
different
components
in
achieve
good
properties,
response
stimuli
such
as
light,
sound,
electricity
resistance.
Conclusively,
provide
a
systematic
summary
findings
(crosslinking
methods)
an
outlook
on
long-lasting
effects,
broader
spectrum,
diversified
forms,
future
development
prospects
field.
Cells,
Год журнала:
2023,
Номер
12(10), С. 1416 - 1416
Опубликована: Май 17, 2023
Extracellular
vesicles
(EVs)
such
as
ectosomes
and
exosomes
have
gained
attention
promising
natural
carriers
for
drug
delivery.
Exosomes,
which
range
from
30
to
100
nm
in
diameter,
possess
a
lipid
bilayer
are
secreted
by
various
cells.
Due
their
high
biocompatibility,
stability,
low
immunogenicity,
favored
cargo
carriers.
The
membrane
of
also
offers
protection
against
degradation,
making
them
desirable
candidate
However,
loading
into
remains
be
challenge.
Despite
strategies
incubation,
electroporation,
sonication,
extrusion,
freeze–thaw
cycling,
transfection
that
been
developed
facilitate
loading,
inadequate
efficiency
still
persists.
This
review
an
overview
current
delivery
using
summarizes
recent
approaches
small-molecule,
nucleic
acid,
protein
drugs
exosomes.
With
insights
these
studies,
we
provide
ideas
more
efficient
effective
molecules
Abstract
The
treatment
of
bone
defects
remains
a
substantial
clinical
challenge
due
to
the
lack
spatiotemporal
management
immune
microenvironment,
revascularization,
and
osteogenic
differentiation.
Herein,
deferoxamine
(DFO)‐loaded
black
phosphorus
nanosheets
decorated
by
polydopamine
layer
are
prepared
(BPPD)
compounded
into
gelatin
methacrylate/sodium
alginate
methacrylate
(GA)
hybrid
hydrogel
as
smart‐responsive
therapeutic
system
(GA/BPPD)
for
accelerated
regeneration.
BPPD
nanocomposites
served
bioactive
components
near‐infrared
(NIR)
photothermal
agents,
which
conferred
with
excellent
NIR/pH
dual‐responsive
properties,
realizing
stimuli‐responsive
release
DFO
PO
4
3
−
during
Under
action
NIR‐triggered
mild
therapy,
GA/BPPD
exhibited
positive
effect
on
promoting
osteogenesis
angiogenesis,
eliminating
excessive
reactive
oxygen
species,
inducing
macrophage
polarization
M2
phenotype.
More
significantly,
through
polarization‐induced
osteoimmune
this
platform
could
also
drive
functional
cytokine
secretion
enhanced
angiogenesis
osteogenesis.
In
vivo
experiments
further
demonstrated
that
facilitate
healing
attenuating
local
inflammatory
response,
increasing
pro‐healing
factors,
stimulating
endogenous
cell
recruitment,
accelerating
revascularization.
Collectively,
proposed
intelligent
provides
promising
strategy
reshape
damaged
tissue
microenvironment
augmented
Advanced Healthcare Materials,
Год журнала:
2023,
Номер
13(4)
Опубликована: Ноя. 9, 2023
Diabetic
wounds
are
more
likely
to
develop
into
complex
and
severe
chronic
wounds.
The
objective
of
this
study
is
assess
a
reactive
oxygen
species
(ROS)-responsive
multifunctional
injectable
hydrogel
for
the
purpose
diabetic
wound
healing.
A
(HA@Cur@Ag)
successfully
synthesized
with
dual
antioxidant,
antibacterial,
anti-inflammatory
properties
by
crosslinking
thiol
hyaluronic
acid
(SH-HA)
disulfide-bonded
hyperbranched
polyethylene
glycol
(HB-PBHE)
through
Michael
addition;
while,
incorporating
curcumin
liposomes
silver
nanoparticles
(AgNPs).
HA@Cur@Ag
exhibits
favorable
biocompatibility,
degradability,
injectivity.
outcomes
in
vitro
vivo
experiments
demonstrate
that
can
effectively
be
loaded
release
liposomes,
as
well
ions,
thereby
facilitating
healing
multiple
mechanisms,
including
ROS
scavenging,
bactericidal
activity,
effects,
promotion
angiogenesis.
Transcriptome
sequencing
reveals
suppresses
activation
tumour
necrosis
factor
(TNF)/nuclear
κB
(NF-κB)
pathway
ameliorate
oxidative
stress
inflammation
These
findings
suggest
ROS-responsive
hydrogel,
which
possesses
ability
precisely
coordinate
integrate
intricate
biological
molecular
processes
involved
healing,
notable
potential
expediting
Advanced Functional Materials,
Год журнала:
2023,
Номер
33(47)
Опубликована: Июль 26, 2023
Abstract
A
long‐standing
quest
in
marine
materials
science
has
been
the
development
of
tough
and
effective
antifouling
coatings
for
diverse
surface
protection.
However,
most
commercial
are
severely
limited
by
poor
mechanical
behavior
unsustainable
passive
biocidal
effect,
leading
to
irreversible
biofouling
even
microbiologically
influenced
corrosion
(MIC).
Herein,
inspired
amorphous/crystalline
feature
within
nacreous
platelets,
a
mechanically
robust
coating
composed
biopolymer‐based
hydrogel
dense
metal‐organic
frameworks
(MOFs)
is
developed.
Tailoring
cross‐linked
networks
across
multiscale
interfaces
can
furnish
strength,
dissipate
strain,
improve
toughness
building
blocks,
resulting
firm
scalable
configuration
on
various
substrates
regardless
material
category
topology.
The
resultant
as
suitable
reservoir
exhibits
unique
active
defensive
intelligent
MOF
degradation
or
drug
release,
enabling
groundbreaking
performance
broad‐spectrum
control.
Notably,
neither
attachment
organisms
nor
MIC
metal
observed
aggravated
during
prolonged
testing
process
complex
biological
environments.
This
study
provides
distinctive
insights
into
underlying
multimechanisms
comprehensive
anti‐fouling‐corrosion
pioneer
rational
strategy
design
next‐generation
reliable
MOFs‐derived
