3D Bioprinting in Limb Salvage Surgery DOI Creative Commons
Iosif-Aliodor Timofticiuc, Şerban Dragosloveanu, Ana Căruntu

и другие.

Journal of Functional Biomaterials, Год журнала: 2024, Номер 15(12), С. 383 - 383

Опубликована: Дек. 19, 2024

With the development of 3D bioprinting and creation innovative biocompatible materials, several new approaches have brought advantages to patients surgical teams. Increasingly more bone defects are now treated using 3D-bioprinted prostheses implementing solutions relies on ability engineers medical teams identify methods anchoring 3D-printed reveal potential influence bioactive materials surrounding tissues. In this paper, we described why limb salvage surgery based is a reliable effective alternative amputations, approach considered standard in modern medicine. The preliminary results one most challenging fields promising for future machine-based medicine, but also possibility replacing various parts from human body with bioactive-based constructs. addition, besides constructs that already tested applied body, reviewed undergoing vitro or vivo testing great applications near future. Also, explored recent advancements clinically available their relevance field.

Язык: Английский

P2O5 enhances the bioactivity of lithium silicate glass ceramics via promoting phase transformation and forming Li3PO4 DOI
Ning-Ze Zhang, Min Zhang, Hongyan Tang

и другие.

Ceramics International, Год журнала: 2024, Номер 50(8), С. 13308 - 13317

Опубликована: Янв. 18, 2024

Язык: Английский

Процитировано

6

Cerium Oxide Nanoparticles-Reinforced GelMA Hydrogel Loading Bone Marrow Stem Cells with Osteogenic and Inflammatory Regulatory Capacity for Bone Defect Repair DOI
Ruideng Wang, Xi He, Jinwu Bai

и другие.

ACS Applied Materials & Interfaces, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 25, 2024

Effective bone defect repair has been a tough clinical challenge due to the complexity of microenvironment. Hydrogels loaded with marrow mesenchymal stem cells (BMSCs) have widely applied for regeneration. However, low survival BMSCs at site transplantation and lack sufficient osteogenic induction capacity greatly limit their applications. In order solve this puzzle, we fabricated gelatin methacryloyl (GelMA) hydrogels containing cerium oxide (CeO

Язык: Английский

Процитировано

5

Tailoring Osteoimmunity and Hemostasis Using 3D-Printed Nano-Photocatalytic Bactericidal Scaffold for Augmented Bone Regeneration DOI
Sayan Deb Dutta, Jin Hexiu, Md Moniruzzaman

и другие.

Biomaterials, Год журнала: 2024, Номер 316, С. 122991 - 122991

Опубликована: Дек. 6, 2024

Язык: Английский

Процитировано

5

Bone Healing via Carvacrol and Curcumin Nanoparticle on 3D Printed Scaffolds DOI Creative Commons
Aditi Dahiya, Vishal Sharad Chaudhari, Susmita Bose

и другие.

Small, Год журнала: 2024, Номер unknown

Опубликована: Окт. 27, 2024

Abstract Carvacrol is a potent antimicrobial and anti‐inflammatory agent, while curcumin possesses antioxidant, anti‐inflammatory, anticancer properties. These phytochemicals have poor solubility, bioavailability, stability in their free form. Nanoencapsulation can reduce these limitations with enhanced translational capability. Integrating nanocarriers 3D‐printed calcium phosphate (CaP) scaffolds presents novel strategy for bone regeneration. curcumin‐loaded nanoparticles (CC‐NP) synthesized melt emulsification produced negatively charged, monodispersed particles hydrodynamic diameter of ≈127 nm. Their release from the scaffold shows biphasic under physiological acidic conditions. At pH 5.0, CC‐NP exhibits 53% nearly 100% carvacrol, compared to 19% 36% respective drug solutions. 7.4, ≈40% 76% carvacrol releases, highlighting pH‐sensitive mechanism. In vitro studies demonstrate 1.4‐fold increase osteoblast cell viability treatment. exhibit cytotoxic effects against osteosarcoma cells, reducing by ≈2.9‐fold. The antibacterial efficacy evaluated Staphylococcus aureus (SA) Pseudomonas aeruginosa (PA) exhibiting 98% efficacy. This approach enhances therapeutic outcomes minimizes potential side associated conventional treatments, paving way innovative applications regenerative medicine.

Язык: Английский

Процитировано

4

3D Bioprinting in Limb Salvage Surgery DOI Creative Commons
Iosif-Aliodor Timofticiuc, Şerban Dragosloveanu, Ana Căruntu

и другие.

Journal of Functional Biomaterials, Год журнала: 2024, Номер 15(12), С. 383 - 383

Опубликована: Дек. 19, 2024

With the development of 3D bioprinting and creation innovative biocompatible materials, several new approaches have brought advantages to patients surgical teams. Increasingly more bone defects are now treated using 3D-bioprinted prostheses implementing solutions relies on ability engineers medical teams identify methods anchoring 3D-printed reveal potential influence bioactive materials surrounding tissues. In this paper, we described why limb salvage surgery based is a reliable effective alternative amputations, approach considered standard in modern medicine. The preliminary results one most challenging fields promising for future machine-based medicine, but also possibility replacing various parts from human body with bioactive-based constructs. addition, besides constructs that already tested applied body, reviewed undergoing vitro or vivo testing great applications near future. Also, explored recent advancements clinically available their relevance field.

Язык: Английский

Процитировано

4