Abstract
Hydrogels
are
prevailing
drug
delivery
depots
to
improve
antitumor
efficacy
and
reduce
systemic
toxicity.
However,
the
application
of
conventional
free
drug‐loaded
hydrogel
is
hindered
by
poor
penetration
in
solid
tumors.
Here,
an
injectable
ferritin‐based
nanocomposite
constructed
facilitate
tumor
cancer
chemoimmunotherapy.
Specifically,
doxorubicin‐loaded
human
ferritin
(Dox@HFn)
oxidized
dextran
(Dex‐CHO)
used
construct
(Dox@HFn
Gel)
through
formation
pH‐sensitive
Schiff‐base
bonds.
After
peritumoral
injection,
Dox@HFn
Gel
retained
locally
for
up
three
weeks,
released
intact
gradually,
which
can
not
only
active
transcytosis
but
also
induce
immunogenic
cell
death
(ICD)
cells
generate
immune
response.
Combining
with
anti‐programmed
death‐1
antibody
(αPD‐1),
induces
remarkable
regression
orthotopic
4T1
breast
tumors,
further
elicits
a
strong
anti‐tumor
response
effectively
suppress
recurrence
lung
metastasis
tumors
after
surgical
resection.
Besides,
combination
L
anti‐CD47
(αCD47)
inhibits
postsurgical
aggressive
glioblastoma
model
significantly
extends
mice
survival.
This
work
sheds
light
on
construction
local
hydrogels
potentiate
improved
therapy.
ACS Nano,
Год журнала:
2024,
Номер
18(28), С. 18604 - 18621
Опубликована: Июль 2, 2024
Chemo-immunotherapy
has
become
a
promising
strategy
for
cancer
treatment.
However,
the
inability
of
drugs
to
penetrate
deeply
into
tumor
and
form
potent
vaccines
in
vivo
severely
restricts
antitumor
effect
chemo-immunotherapy.
In
this
work,
an
injectable
sodium
alginate
platform
is
reported
promote
penetration
chemotherapeutic
doxorubicin
(DOX)
delivery
personalized
vaccines.
The
multifunctional
cross-links
rapidly
presence
physiological
concentrations
Ca2+,
forming
hydrogel
that
acts
as
drug
depot
releases
loaded
hyaluronidase
(HAase),
DOX,
micelles
(IP-NPs)
slowly
sustainedly.
By
degrading
hyaluronic
acid
(HA)
overexpressed
tissue,
HAase
can
make
tissue
"loose"
favor
other
components
deeply.
DOX
induces
immunogenic
cell
death
(ICD)
produces
tumor-associated
antigens
(TAAs),
which
could
be
effectively
captured
by
polyethylenimine
(PEI)
coated
IP-NPs
efficaciously
facilitate
maturation
dendritic
cells
(DCs)
activation
T
lymphocytes,
thus
producing
long-term
immune
memory.
Imiquimod
(IMQ)
core
further
activate
system
trigger
more
robust
effect.
Hence,
research
proposes
effective
treatment
colorectal
cancer.
ACS Nano,
Год журнала:
2024,
Номер
18(26), С. 16359 - 16394
Опубликована: Июнь 11, 2024
Glioblastoma
(GBM)
remains
the
epitome
of
aggressiveness
and
lethality
in
spectrum
brain
tumors,
primarily
due
to
blood–brain
barrier
(BBB)
that
hinders
effective
treatment
delivery,
tumor
heterogeneity,
presence
treatment-resistant
stem
cells
contribute
recurrence.
Nanoparticles
(NPs)
have
been
used
overcome
these
obstacles
by
attaching
targeting
ligands
enhance
therapeutic
efficacy.
Among
ligands,
peptides
stand
out
their
ease
synthesis
high
selectivity.
This
article
aims
review
single
multiligand
strategies
critically.
In
addition,
it
highlights
other
integrate
effects
external
stimuli,
biomimetic
approaches,
chemical
approaches
as
nanocatalytic
medicine,
revealing
significant
potential
treating
GBM
with
peptide-functionalized
NPs.
Alternative
routes
parenteral
administration,
specifically
nose-to-brain
delivery
local
within
resected
cavity,
are
also
discussed.
Finally,
an
overview
them
discussed
provide
a
perspective
on
this
promising
field
therapy.
Environmental Science Nano,
Год журнала:
2024,
Номер
11(5), С. 2239 - 2248
Опубликована: Янв. 1, 2024
Tannic
acid
derived
carbon
dot
(TACD)-embedded
gelatin
hydrogels
(GTACDs)
were
formed
by
hydrogen
bonding
and
electrostatic
interactions,
which
as
seed
coating
applied
to
drought
soil
enhance
crop
resistance
growth.
The Innovation Materials,
Год журнала:
2024,
Номер
2(1), С. 100051 - 100051
Опубликована: Янв. 1, 2024
<p>Magnetic
nanoparticle-mediated
hyperthermia
(MHT)
is
a
promising
tumor
theranostic
technology
due
to
its
noninvasive
nature
and
ability
penetrate
deep
tissues
without
greatly
damaging
normal
tissues.
To
advance
the
clinical
translation
application
of
MHT,
we
present
comprehensive
overview
topics
related
including
basic
physical
heating
principles,
magnetic
nanoparticle
design,
biological
effects
applications.
First,
fundamental
principles
through
which
nanoparticles
mediate
are
reviewed
in
detail.
Subsequently,
strategies
increase
magnetothermal
effect
MHT
highlighted.
Then,
multitechnology
integration
applications
precision
diagnosis
treatment
introduced.
Finally,
key
challenges
outlooks
for
purposes
discussed.</p>
Abstract
Deep
penetration
and
downregulation
of
heat
shock
protein
(HSP)
expression
in
multimodal
synergistic
therapy
are
promising
approaches
for
curing
cancer
clinical
trials.
However,
free
small‐molecule
drugs
most
drug
vehicles
have
a
low
delivery
efficiency
deep
into
the
tumor
owing
to
poor
hypoxic
conditions
at
site.
In
this
study,
objective
is
use
reactive
oxygen
species
(ROS)‐responsive
supramolecular
gels
co‐loaded
with
photosensitizer
Zn(II)
phthalocyanine
tetrasulfonic
acid
(ZnPCS
4
)
functionalized
tetrahedral
DNA
(TGSAs)
(G@P/TGSAs)
enhance
tissue
cell
block
HSP90
pathway
chemo‐
photodynamic
(PDT)
‐
photothermal
(PTT)
trimodal
therapy.
The
injected
situ
release
ZnPCS
TGSAs
under
high
ROS
concentrations
originating
from
both
PDT.
penetrate
deeply
tissues
augment
by
inhibiting
pathway.
Proteomics
show
that
HSP‐related
proteins
molecular
chaperones
inhibited/activated,
Simultaneously,
TGSA‐regulated
apoptotic
activated.
vivo
study
demonstrates
efficient
excellent
(45%
growth
inhibition).
Device,
Год журнала:
2023,
Номер
1(3), С. 100092 - 100092
Опубликована: Сен. 1, 2023
Body-conformal
sensors
and
tissue-interfacing
robotic
therapeutics
enable
the
real-time
monitoring
treatment
of
diabetes,
wound
healing,
other
critical
conditions.
By
integrating
drug-delivery
devices,
scientists
engineers
have
developed
closed-loop
systems
with
on-demand
therapeutic
capabilities
to
provide
just-in-time
treatments
that
correspond
chemical,
electrical,
physical
signals
a
target
morbidity.
To
functionality
in
vivo,
utilize
various
low-power
means
communication
reduce
size
implants
by
orders
magnitude,
increase
device
lifetime
from
hours
months,
ensure
secure
high-speed
transfer
data.
In
this
review,
we
highlight
how
protocols
used
integrate
such
as
radio-frequency
(e.g.,
Bluetooth,
near-field
communication),
in-body
communication,
ultrasound,
improved
outcomes.
