Nano-Micro Letters,
Год журнала:
2024,
Номер
17(1)
Опубликована: Сен. 30, 2024
Abstract
Vaccinations
are
essential
for
preventing
and
treating
disease,
especially
cancer
nanovaccines,
which
have
gained
considerable
interest
recently
their
strong
anti-tumor
immune
capabilities.
Vaccines
can
prompt
the
system
to
generate
antibodies
activate
various
cells,
leading
a
response
against
tumor
tissues
reducing
negative
effects
recurrence
risks
of
traditional
chemotherapy
surgery.
To
enhance
flexibility
targeting
vaccines,
nanovaccines
utilize
nanotechnology
encapsulate
or
carry
antigens
at
nanoscale
level,
enabling
more
controlled
precise
drug
delivery
responses.
Cancer
function
by
encapsulating
tumor-specific
tumor-associated
within
nanomaterials.
The
small
size
these
nanomaterials
allows
T
dendritic
thereby
eliciting
potent
response.
In
this
paper,
we
focus
on
classification
carriers
roles
different
target
clinically
tested
discussing
strategies
effectively
inducing
cytotoxic
lymphocytes
responses
optimizing
antigen
presentation,
while
also
looking
ahead
translational
challenges
moving
from
animal
experiments
clinical
trials.
Materials Today Bio,
Год журнала:
2024,
Номер
29, С. 101326 - 101326
Опубликована: Ноя. 9, 2024
Ion
interference,
including
intracellular
copper
(Cu)
overload,
disrupts
cellular
homeostasis,
triggers
mitochondrial
dysfunction,
and
activates
cell-specific
death
channels,
highlighting
its
significant
potential
in
cancer
therapy.
Nevertheless,
the
insufficient
Cu
ions
transported
by
existing
ionophores,
which
are
small
molecules
with
short
blood
half-lives,
inevitably
hamper
effectiveness
of
cuproptosis.
Herein,
ESCu@HM
nanoreactor,
self-assembled
from
integration
H-MnO
Small Structures,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 14, 2025
As
two
main
phototherapy
means,
photodynamic
therapy
(PDT)
and
photothermal
(PTT)
have
different
photon‐transition
avenues
decided
by
the
aggregation
state
of
photosensitizers
(PSs),
thus
PDT
or
PTT
efficiency
can
be
regulated
regulating
PSs
aggregation.
A
co‐assembly
formulation
consisting
IR780
iodide
pentafluorophenyl
trifluoroacetate
is
constructed
through
intermolecular
interactions,
followed
coating
with
hyaluronic
acid.
Initially,
uniform
distribution
favors
more
reactive
oxygen
species
birth
to
implement
when
entering
cells
since
its
avenue
sequential
process
intersystem
crossing
transfer–collision
energy
transfer
predominant.
After
hyaluronidase
laser
irradiation‐induced
structural
collapse
co‐assembly,
free
aggregates
due
hydrophobic
interactions
even
though
they
are
excreted
out
cells,
then,
these
produce
heat
nonradiative
relaxation
execute
PTT.
Such
a
spatiotemporal
PDT–PTT
encourages
antitumor
immune
responses
mitigates
immunosuppression,
accomplishing
photoimmunotherapy
against
breast
cancer
progression.
Through
such
tumor
microenvironment‐adaptable
laser‐duration‐decided
alteration,
switching
insights
provided
into
single
PSs‐mediated
photoimmunotherapy.
ACS Applied Materials & Interfaces,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 4, 2025
Chimeric
antigen
receptor
(CAR)
immune
cell
therapies
have
revolutionized
oncology,
particularly
in
hematological
malignancies,
yet
their
efficacy
against
solid
tumors
remains
limited
due
to
challenges
such
as
dense
stromal
barriers
and
immunosuppressive
microenvironments.
With
advancements
nanobiotechnology,
researchers
developed
various
strategies
methods
enhance
the
CAR
tumor
treatment.
In
this
Review,
we
first
outline
structure
mechanism
of
CAR-T
(T,
T
cell),
CAR-NK
(NK,
natural
killer),
CAR-M
(M,
macrophage)
deeply
analyze
potential
these
cells
treatment
they
face.
Next,
explore
how
biomaterials
can
optimize
treatments
by
improving
microenvironment,
controlling
release,
promoting
infiltration,
enhancing
efficacy.
Finally,
summarize
current
solutions,
emphasize
effective
combination
therapy,
look
forward
its
future
clinical
application
strategies.
This
Review
provides
important
theoretical
perspectives
practical
guidance
for
development
more
