Science China Materials, Год журнала: 2024, Номер 67(9), С. 2796 - 2806
Опубликована: Июль 4, 2024
Язык: Английский
Advanced Materials, Год журнала: 2023, Номер 36(8)
Опубликована: Окт. 11, 2023
Abstract Activating the strong immune system is a key initiative to counteract dormant tumors and prevent recurrence. Herein, self‐destructive multienzymatically active copper‐quinone‐GOx nanoparticles (abbreviated as CQG NPs) have been designed induce harmonious balanced pyroptosis cuproptosis using “Tai Chi mindset” awaken response for suppressing recurrent tumors. This cleverly material can disrupt antioxidant defense mechanism of tumor cells by inhibiting nuclear factor‐erythroid 2‐related factor 2 (NRF2)‐quinone oxidoreductase 1 (NQO1) signaling pathway. Furthermore, combined with its excellent multienzyme activity, it activates NOD‐like receptor protein 3 (NLRP3)‐mediated pyroptosis. Meanwhile, be triggered copper ions released from disintegration NPs sensitivity cancer enhanced through depletion endogenous chelators via Michael addition reaction between glutathione (GSH) quinone ligand, oxygen production catalase‐like reaction, starvation‐induced glucose deficiency. More importantly, NPs‐induced promote immunosuppressive microenvironment (TME) remodeling, enhance infiltration into tumor, activate robust systemic immunity. Collectively, this study provides new strategy resist dormancy, recurrence, improve clinical prognosis
Язык: Английский
Процитировано
83
European Polymer Journal, Год журнала: 2024, Номер 205, С. 112718 - 112718
Опубликована: Янв. 2, 2024
In the contemporary era, novel manufacturing technologies like additive (AM) have revolutionized different engineering sectors including biomedical, aerospace, electronics, etc. Four-dimensional (4D) printing aka AM of smart materials is gaining popularity among scientific community, which has excellent ability to make soft structures such as robots, actuators, and grippers. These are developed by applying various stimuli pH, temperature, magnetic field, many combinations onto materials. Stimuli in 3D permit shape-morphing behaviors bending, twisting, folding, swelling, rolling, shrinking, origami, or locomotion. A wide variety can be fabricated through incorporation hard particles into resulting magneto-active (MASMs). With this integration, magneto-thermal coupling actuation allows diverse magneto-deformations, facilitating development personalized devices that capable enhanced deformation. review, guidelines provided on for MASMs polymers (MAPs), composites, hydrogels (MAHs) booming flexible wearable biomimetic devices. Moreover, 3D-printed robotics an outstanding capacity adapt complicated situations advanced actuating applications. Finally, some current challenges emerging areas exciting technology been proposed. Lastly, it anticipated technological advancements developing intelligent will a significant impact design real-world
Язык: Английский
Процитировано
71
Nature Communications, Год журнала: 2024, Номер 15(1)
Опубликована: Апрель 25, 2024
Abstract Soft actuators produce the mechanical force needed for functional movements of soft robots, but they suffer from critical drawbacks since previously reported often rely on electrical wires or pneumatic tubes power supply, which would limit potential usage robots in various practical applications. In this article, we review new types untethered that represent breakthroughs and discuss future perspective actuators. We materials innovative strategies gave rise to deliver our challenges opportunities future-generation
Язык: Английский
Процитировано
27
npj Spintronics, Год журнала: 2024, Номер 2(1)
Опубликована: Июль 2, 2024
Abstract In the past decade, there has been a significant rise in development of novel spintronic device architectures specifically designed to meet demands diverse biomedical applications. These advancements have notably focused on enhancing various bioassay detection techniques, including magnetocardiography and neural signal recording. Through collaboration within spintronics community, these devices are rapidly transitioning from laboratory prototypes practical applications, catering applications benefiting both researchers medical practitioners alike. this review, we comprehensively explore devices, due their inherent sensitivity external magnetic fields, ease fabrication into large arrays nano/micro-sized confined spaces, resilience under harsh environmental conditions, high repeatability. Established that exploit magnetoresistive effects already extensively deployed as biosensors for disease diagnosis, imaging, bio-magnetic field detection, offering superior robustness. This review aims provide peers with an up-to-date overview contexts while also commenting future research trends challenges. With nano/microfabrication techniques robustness sensitivity, it is foreseeable could catalyze revolutionary transformations healthcare.
Язык: Английский
Процитировано
10
ACS Nano, Год журнала: 2025, Номер unknown
Опубликована: Фев. 19, 2025
Cancer poses a substantial threat and serious challenge to public human health, driving the promotion of sophisticated technologies for cancer therapy. While conventional chemotherapy has bottlenecks such as low delivery efficiency, strong toxic side effects, tumor enrichment barriers, magnetic micro/nanorobots (MNRs) emerge promising therapeutic candidates that provide alternative strategies MNR is kind human-made machine micro- or nanosized, reasonably designed, performs command tasks through self-actuated externally controlled propulsion mechanisms, which can be potentially applied in theranostics. Here, this review first introduces components constitute typical MNR, including body part, control function sensing part. Subsequently, elucidates representative fabrication methods construct MNRs from top-down approaches bottom-up approaches, covering injection molding, self-rolling, melt electrospinning writing, deposition, biotemplate method, lithography, assembling, 3D printing, chemical synthesis. Furthermore, focuses on multiple applications facing diagnosis treatment, encompassing imaging, quantification, drug release, synergy with therapies, cell manipulation, surgical assistance. Then, systematically elaborates biocompatibility biosafety MNRs. Finally, challenges faced by are discussed alongside future research directions. This intended scientific guidance may improve comprehension cognition theranostics platform MNRs, promoting prospering practical application development
Язык: Английский
Процитировано
1
Micromachines, Год журнала: 2023, Номер 14(12), С. 2173 - 2173
Опубликована: Ноя. 29, 2023
The emergence of magnetic polymer composites has had a transformative impact on the field soft robotics. This overview will examine various methods by which innovative materials can be synthesized and utilized. advancement robotic systems been significantly enhanced utilization composites, amalgamate pliability polymers with reactivity materials. study extensively examines production methodologies involved in dispersing particles within matrices controlling their spatial distribution. objective is to gain insights into strategies required attain desired mechanical properties. Additionally, this delves potential applications these robotics, encompassing devices such as actuators, grippers, wearable gadgets. emphasizes capabilities offer novel framework for biocompatible, versatile that utilize actuation.
Язык: Английский
Процитировано
17
Advanced Electronic Materials, Год журнала: 2024, Номер 10(5)
Опубликована: Янв. 11, 2024
Abstract In recent years, there is a meteoric rise in the prevalence of electronic wearables, and flexible wearables have attracted tremendous attention human–machine interfaces due to their high biocompatibility, functionality, conformability, low‐cost. Flexible magnetic smart skin part this rapidly progressing field wearable electronics, which has paved way for new path human perceptual development, as they may form perception, also known sense, that is, capacity detect interact with fields. review, concept defined: magnetoelastomers sensors. magnetoelastomers, different sources field, structures, applications are summarized by renowned research. sensors, substrates, sensor types, summarized. This review further concludes discussing outlook current challenges interfaces.
Язык: Английский
Процитировано
7
Micromachines, Год журнала: 2024, Номер 15(3), С. 313 - 313
Опубликована: Фев. 24, 2024
This article explores the challenges of continuum and magnetic soft robotics for medical applications, extending from model development to an interdisciplinary perspective. First, we established a unified framework based on algebra geometry. The research progress in principle models, data-driven, hybrid modeling were then analyzed depth. Simultaneously, numerical analysis was constructed. Furthermore, expanded encompass conducted comprehensive analysis, including in-depth case study. Current need address meta-problems identified through discussion. Overall, this review provides novel perspective understanding complexities paving way researchers assimilate knowledge domain rapidly.
Язык: Английский
Процитировано
7
ACS Nano, Год журнала: 2024, Номер 18(12), С. 8694 - 8705
Опубликована: Март 11, 2024
Small-scale magnetic robots with fixed magnetizations have limited locomotion modes, restricting their applications in complex environments vivo. Here we present a morphology-reconfigurable millirobot that can switch the modes locally by reprogramming its during navigation, response to distinct field patterns. By continuously switching between high-velocity rigid motion and high-adaptability soft actuation, efficiently navigates small lumens intricate internal structures surface topographies. As demonstrations, performs multimodal including woodlouse-like rolling flipping, sperm-like rotating, snake-like gliding negotiate different terrains, unrestricted channel high platform, narrow channel, solid–liquid interface, respectively. Finally, demonstrate drug delivery capability of through oviduct-mimicking phantom ex vivo oviduct. The magnetization strategy navigation represents promising approach for developing self-adaptive performing tasks
Язык: Английский
Процитировано
7
ACS Applied Materials & Interfaces, Год журнала: 2024, Номер 16(3), С. 4249 - 4260
Опубликована: Янв. 10, 2024
External stimuli can trigger changes in temperature, concentration, and momentum between micromotors the medium, causing their propulsion enabling them to perform different tasks with improved kinetic efficiencies. Light-activated are attractive systems that achieve motion have potential for high spatiotemporal control. Photophoretic swarming represents an means induce micromotor movement through generation of temperature gradients move from cold hot regions. The studied herein assembled Fe3O4 nanoparticles, NaGdF4:Yb3+,Er3+/NaGdF4:Yb3+ LiYF4:Yb3+,Tm3+ upconverting nanoparticles. nanoparticles were localized one hemisphere produce a Janus architecture facilitates upconversion luminescence distributed throughout. Under 976 nm excitation, generate gradient, while visible light is used tracking triggering reactive oxygen species generation. As such, application achieved using single excitation wavelength. To demonstrate practicality this system, curcumin was adsorbed surface degradation Rhodamine B rates over twice as fast static micromotors. also track image frame, providing convenient understand trajectory these systems. Together, system provides versatile approach achieving light-driven taking advantage applications such detection, sensing, nanothermometry, particle velocimetry, photodynamic therapy, pollutant degradation.
Язык: Английский
Процитировано
6