High-fidelity
wireless
electrophysiological
monitoring
is
essential
for
ambulatory
healthcare
applications.
Soft
solid-like
hydrogels
have
received
significant
attention
as
epidermal
electrodes
because
of
their
tissue-like
mechanical
properties
and
high
biocompatibility.
However,
it
challenging
to
develop
a
hydrogel
electrode
that
provides
robust
contact
adhesiveness
with
glabrous
skin
hairy
scalp
high-fidelity,
continuous
signal
detection.
Here,
paintable,
fast
gelation,
highly
adhesive,
conductive
engineered
high-fidelity
monitoring.
The
hydrogel,
consisting
gelatin,
gallic
acid,
sodium
citrate,
lithium
chloride,
glycerol,
Tris-HCl
buffer
solution
exhibits
reversible
thermal
phase
transition
capability,
which
endows
the
attributes
on-skin
applicability
in
situ
gelation
15
s,
thereby
addressing
aforementioned
limitations.
introduction
acid
enhances
adhesive
facilitating
secure
attachment
or
scalp.
To
accentuate
potential
applications
at-home
health
monitoring,
are
demonstrated
electrocardiogram
recording
one
hour
during
various
daily
activities,
well
simultaneous
electroencephalogram
30
min
nap.
A
hydrogel
with
tissue-like
softness
and
ideal
biocompatibility
has
emerged
as
a
promising
candidate
for
bioelectronics,
especially
in
bidirectional
bioelectrical
transduction
communication.
Conformal
standardized
biointerfaces
are
urgent
demand
to
bridge
electronic
devices
irregular
tissue
surfaces.
Herein,
we
presented
shape-adaptative
electroactive
tissue-adapted
conductivity
(≈1.03
S/m)
by
precisely
regulating
molecular
chains
polymer
networks
of
multisource
gelatin
at
the
scale.
Local
amine-carboxylate
electrostatic
domains
formed
ion
interactions
between
sodium
citrate
significantly
enhance
physiological
adaptability
regulate
biodegradation
period.
Benefiting
from
reversible
fluid-gel
transition
property,
can
be
situ
gelatinized
establish
dynamic
compliance
bioelectronic
interface
tissues
chemical
bonding
physical
topological
effect.
Further,
mechanical-electrical
coupling
capacity
allows
conduction
function
reconstruction
electrical
stimulation
therapy
after
mechanical
bridging
defects
boost
regeneration
sensory
restoration.
ACS Applied Materials & Interfaces,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 1, 2025
Nanomaterial-based
field-effect
transistors
(nano-FETs)
are
pivotal
bioelectronic
devices
that
employed
for
the
detection
of
biomolecular
signals,
cellular
interactions,
and
tissue
responses
within
biosystems.
The
performance
these
nano-FETs
is
significantly
influenced
by
interfacial
characteristics
between
metal
electrodes
semiconductor
nanomaterials,
necessitating
precise
regulation.
While
piezotronic
effect
a
commonly
method
regulation,
it
faces
limitations
in
certain
application
scenarios,
particularly
vivo
settings.
In
this
study,
novel
magnetically
controllable
piezoelectric
device
(MCPD)
designed
combining
principles
nano-FET
biosensors
with
flexibility
magnetic
soft
robots.
This
allows
remote,
precise,
stable
modulation
metal-semiconductor
interface
properties
MCPD
through
field
(MF)-induced
effect.
Consequently,
leads
to
enhanced
sensitivity
biomolecules
such
as
dopamine
recording
neural
electrical
impulses.
exhibits
reversible
transition
flat
bent
state
upon
MF
varying
strengths
directions,
response
duration
only
few
seconds.
Furthermore,
unique
structure
facilitates
semi-invasive
can
be
brought
into
contact
cerebral
cortex
when
required,
thereby
improving
biocompatibility
reducing
invasiveness.
innovation
not
broadens
scenarios
but
also
enables
remote
offering
expanded
utility
applications,
implanted
devices,
provides
potential
strategy
activation
implantable
materials.
The
field
of
bioelectronics
has
witnessed
significant
advancements,
offering
practical
solutions
for
personalized
healthcare
through
the
acquisition
and
analysis
skin-based
physical,
chemical,
electrophysiological
signals.
Despite
these
current
face
several
challenges,
including
complex
preparation
procedures,
poor
skin
adherence,
susceptibility
to
motion
artifacts,
limited
personalization
reconfigurability
capabilities.
In
this
study,
we
introduce
an
innovative
method
fabricating
erasable
on
a
flexible
substrate
coating
adhered
using
ballpoint
pen
without
any
postprocessing.
Our
approach
yields
devices
that
are
thin,
erasable,
reconfigurable,
dry-friction
resistant,
self-healing,
highly
customizable.
We
demonstrate
multifunctionality
on-skin
their
application
as
strain
sensors
monitoring,
temperature
humidity
breath
heating
elements
target
point
hyperthermia.
potential
our
in
medicine
is
substantial,
particularly
health
monitoring.
provide
novel
solution
achieving
efficient
convenient
medical
services,
addressing
limitations
existing
technologies
paving
way
next-generation
wearable
devices.
Advanced Functional Materials,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 21, 2025
Abstract
Stretchable
electronics
offer
a
promising
body‐integrated
platform
for
next‐generation
biomedical
devices.
However,
significant
barrier
to
their
therapeutic
efficacy
lies
in
the
absence
of
an
efficient
transdermal
delivery
modality.
This
study
presents
stretchable
electronic
patch
equipped
with
porous
microneedles,
specifically
designed
wearable
treatment
cancer.
incorporates
MXene
heater
that
maintains
stable
temperatures
when
subjected
tensile
deformations.
Additionally,
textile
dressing
component
utilizes
embedded
phase
change
carriers
enable
on‐demand
release
anticancer
medications
through
electrothermal
activation.
The
produced
via
3D
printing,
are
engineered
effectively
penetrate
epidermis,
thereby
facilitating
successful
drug
delivery.
Complementing
these
features
flexible
circuit
and
compact
battery,
which
together
form
untethered
system
capable
executing
remote
commands
from
smartphone.
combination
chemothermal
therapy
control
has
demonstrated
substantial
inhibiting
growth
subcutaneous
tumors.
These
advancements
underscore
potential
personalized
therapies
permit
uninterrupted
daily
activities.
High-fidelity
wireless
electrophysiological
monitoring
is
essential
for
ambulatory
healthcare
applications.
Soft
solid-like
hydrogels
have
received
significant
attention
as
epidermal
electrodes
because
of
their
tissue-like
mechanical
properties
and
high
biocompatibility.
However,
it
challenging
to
develop
a
hydrogel
electrode
that
provides
robust
contact
adhesiveness
with
glabrous
skin
hairy
scalp
high-fidelity,
continuous
signal
detection.
Here,
paintable,
fast
gelation,
highly
adhesive,
conductive
engineered
high-fidelity
monitoring.
The
hydrogel,
consisting
gelatin,
gallic
acid,
sodium
citrate,
lithium
chloride,
glycerol,
Tris-HCl
buffer
solution
exhibits
reversible
thermal
phase
transition
capability,
which
endows
the
attributes
on-skin
applicability
in
situ
gelation
15
s,
thereby
addressing
aforementioned
limitations.
introduction
acid
enhances
adhesive
facilitating
secure
attachment
or
scalp.
To
accentuate
potential
applications
at-home
health
monitoring,
are
demonstrated
electrocardiogram
recording
one
hour
during
various
daily
activities,
well
simultaneous
electroencephalogram
30
min
nap.
