Abstract
The
emergence
of
drug
resistance
in
bacteria,
along
with
the
protective
nature
and
intricate
environment
biofilms,
impedes
effective
treatment
severe
bacterial
infections,
posing
significant
health
risks.
Herein,
a
coordination
polymer
nanoparticle
(LZC)
is
fabricated
via
facile
situ
strategy
for
sonodynamic
therapy
(SDT)
combating
drug‐resistant
bacteria‐induced
infections.
By
conjugating
Food
Drug
Administration
(FDA)‐approved
safe
sonosensitizer
porphyrin
chlorin
e6
(Ce6)
positively
charged
antimicrobial
peptide
LL37
through
interaction,
resultant
LZC
exhibits
uniform
size
surface,
which
beneficial
efficient
capture
bacteria
improved
penetration
into
biofilms.
Under
ultrasound
(US)
stimuli,
generates
higher
reactive
oxygen
species
(ROS)
compared
free
sonosensitizers,
as
well
production
heat,
leading
to
cell
death
biofilm
disruption.
In
vitro
evaluations
reveal
robust
antibacterial
activity
LZC,
achieving
up
99%
eradication
multi‐drug
resistant
Pseudomonas
aeruginosa
(MDRPA)
under
deep‐penetrating
US
irradiation.
Moreover,
establishment
nanoparticles
represents
an
innovative
enhance
SDT
MDRPA‐induced‐pneumonia
mice
model
provides
great
promise
advancing
therapeutic
interventions
deep
tissue
Abstract
Diabetic
wounds
pose
a
persistent
challenge
due
to
their
slow
healing
nature,
primarily
caused
by
bacterial
infection
and
excessive
reactive
oxygen
species
(ROS)‐induced
inflammation.
In
this
study,
carbon
dots
with
synergistic
antibacterial
antioxidant
properties,
referred
as
AA‐CDs,
are
developed
specifically
for
diabetic
wound
using
straightforward
solvothermal
method.
By
utilizing
cost‐effective
precursors
like
citric
acid
ascorbic
acid,
AA‐CDs
engineered
possess
tailored
functions
of
photothermal
sterilization
ROS
scavenging.
The
resulting
demonstrats
broad‐spectrum
activity,
particularly
against
multidrug‐resistant
strains,
along
efficient
scavenging
both
in
solution
within
cells.
Additionally,
exhibits
protective
effect
oxidative
stress‐induced
damage.
Notably,
high
conversion
efficiency
(41.18%),
displays
heat‐enhanced
performance,
providing
not
only
augmented
but
also
additional
protection
stress,
yielding
true
“1
+
1
>
2”
effect.
To
facilitate
use
vivo,
incorporated
into
thermally
responsive
hydrogel,
which
evident
anti‐inflammatory
properties
modulating
inflammatory
factors
significantly
promots
the
wounds.
This
study
underscores
value
integrated
platforms
highlights
potential
versatile
CDs
promising
therapeutic
agents
biomedical
applications.
Abstract
Spoiled
food
has
significantly
impacted
the
global
economy
and
public
health,
which
increases
worldwide
concern
about
monitoring
preserving
freshness.
Herein,
a
multi‐functional
type‐I
heterojunction
(Eu@ZMC)
is
designed
by
europium
metal‐organic
framework
(EuMOF),
zinc
oxide
quantum
dots
(ZnO
QDs),
chlorogenic
acid
(CGA).
Eu@ZMC
achieves
ratiometric
fluorescent/colorimetric
sensing
of
pH
biogenic
amines
to
detect
Besides,
paper‐based
platform
(PEu@ZMC)
prepared
can
histamine
with
LOD
0.0142
0.0136
µg
mL
−1
in
fluorescent
colorimetric
modes,
respectively.
An
advanced
OR/NOT‐gate
logic
device
further
constructed
distinguish
freshness
into
three
levels
(fresh,
less
fresh,
spoiled).
This
dual‐mode
sensor
synergistic‐enhanced
energy
transfer
triggered
ZnO
QDs‐promoted
colorimetry
heterostructure
EuMOF
QDs.
The
release
low‐toxic
ions
inhibits
various
bacterial
growth,
including
Salmonella
typhimurium
.
According
raw
fish
evaluation,
not
only
effectively
monitors
spoilage
externally
internally
aligning
commercial
kit,
but
also
reduces
speed,
cannot
be
achieved
through
classical
detection
strategy.
original
work
provides
simple,
convenient,
reliable
method
for
multi‐depth
real‐time
visual
extract
preservation,
contributing
economic
benefits
human
health
assurance.
Advanced Healthcare Materials,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 20, 2024
Periodontitis
is
a
chronic
inflammatory
disease
caused
by
dental
plaque,
which
leads
to
tooth
loosening
and
shifting
or
even
loss.
Current
treatments,
including
mechanical
debridement
antibiotics,
often
fail
eradicate
recalcitrant
biofilms
mitigate
excessive
inflammation.
Moreover,
these
interventions
can
disrupt
the
oral
microbiome,
potentially
compromising
long-term
treatment
outcomes.
To
address
limitations,
an
injectable
nanoenzyme
hydrogel
composed
of
dopamine
(DA)-modified
hyaluronic
acid
(HA)
scaffold
graphdiyne-iron
(GDY-Fe)
complex,
named
GDY-Fe@HA-DA,
exhibits
excellent
tissue
adhesion,
self-healing,
antibacterial
properties,
biocompatibility.
Under
near-infrared
laser
irradiation,
GDY-Fe@HA-DA
effectively
eradicates
variety
pathogens,
Escherichia
coli,
Staphylococcus
aureus,
Porphyromonas
gingivalis,
through
synergistic
combination
chemodynamical
photothermal
therapies.
The
hydrogel's
efficacy
further
validated
in
both
bacterial-infected
skin
wounds
rat
periodontitis
models.
It
alleviates
environment
promotes
wound
healing
periodontal
recovery.
This
findings
highlight
potential
as
promising
therapeutic
material
for
other
injuries.
