Engineering nanomedicines for neuroprotection and neuroregeneration in spinal cord injury

Nano Today, Год журнала: 2025, Номер 61, С. 102643 - 102643

Опубликована: Янв. 20, 2025

Язык: Английский

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Spinal Cord Injury Repair Based on Drug and Cell Delivery: from Remodeling Microenvironment to Relay Connection Formation

Materials Today Bio, Год журнала: 2025, Номер 31, С. 101556 - 101556

Опубликована: Фев. 4, 2025

Spinal cord injury (SCI) presents a formidable challenge in clinical settings, resulting sensory and motor function loss imposing significant personal societal burdens. However, owning to the adverse microenvironment limited regenerative capacity, achieving complete functional recovery after SCI remains elusive. Additionally, traditional interventions including surgery medication have series of limitations that restrict effectiveness treatment. Recently, tissue engineering (TE) has emerged as promising approach for promoting neural regeneration SCI, which can effectively delivery drugs into site cells improve survival differential. Here, we outline main pathophysiology events post injury, further discuss materials common assembly strategies used scaffolds treatment, expound on latest advancements treatment methods based drug cell detail, propose future directions repair with TE highlight potential applications.

Язык: Английский

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Neurological Emergency Treatment Strategy: A Neuron-Targeted Regulation System for Reactive Oxygen Species Metabolism through Ferroptosis Modulation

ACS Nano, Год журнала: 2025, Номер unknown

Опубликована: Фев. 25, 2025

Spinal cord injury (SCI) represents a significant clinical challenge. Following SCI, the implementation of protective measures for neurons is critically important. Current applications hormone pulse therapy exhibit variable efficacy and considerable side effects, highlighting an urgent need therapeutic strategies. This study investigates pathological conditions ischemia hypoxia in SCI region, complemented by early transcriptome sequencing postinjury. Our findings suggest that targeting ferroptosis pivotal neuroprotection following SCI. Aiming at cascade effect mitochondrial damage leading to reactive oxygen species (ROS) production, along with extensive ROS-mediated lysosomal during signaling, we developed liposome-based system regulating iron metabolism─DTLS@CAT. innovative liposome designed specifically target neuronal mitochondria, effectively eliminate mitoROS, modulate complex interactions among metabolism, lysosomes, ROS facilitate recovery from

Язык: Английский

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Influences of chain length and conformation of guanidinylated linear synthetic polypeptides on nuclear delivery of siRNA with potential application in transcriptional gene silencing

International Journal of Biological Macromolecules, Год журнала: 2025, Номер unknown, С. 142743 - 142743

Опубликована: Апрель 1, 2025

Язык: Английский

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Cation-π interaction mediated, anti-swelling, high-toughness and conductive hydrogel for regulation of PC12 neurite outgrowth

European Polymer Journal, Год журнала: 2025, Номер unknown, С. 113928 - 113928

Опубликована: Апрель 1, 2025

Язык: Английский

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Neutrophil-like Cell membrane-Coated Molybdenum-based Nanoclusters for Reduced Oxidative Stress and enhanced Neurological Recovery after Intracerebral Hemorrhage

Acta Biomaterialia, Год журнала: 2025, Номер unknown

Опубликована: Апрель 1, 2025

Язык: Английский

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Biomaterial-mediated delivery of traditional Chinese medicine ingredients for spinal cord injury: a systematic review

Frontiers in Pharmacology, Год журнала: 2024, Номер 15

Опубликована: Окт. 31, 2024

Biomaterials loaded with ingredients derived from traditional Chinese medicine (TCM) are viewed as a promising strategy for treating spinal cord injury (SCI). However, comprehensive analysis of the existing literature on this topic has not yet been conducted. Therefore, paper systematically reviews researches related to approach, aiming identify gaps and shortcomings in field. PubMed, EMBASE, Web Science, Biomedical Literature, Wanfang, China National Knowledge Infrastructure (CNKI) were searched retrieving studies biomaterials TCM published their inception October 2024. Two reviewers performed screening search results, information extraction, quality assessment independently. For systematic review, 41 publications included. Six ingredients-paclitaxel, curcumin, tetramethylpyrazine, resveratrol, berberine, tanshinone IIA combined treatment SCI. categorized into hydrogels, biodegradable scaffolds, nanoparticles, microspheres according type scaffold. These drug delivery systems exhibit commendable biocompatibility, drug-loading capacity, drug-release capabilities, combination ingredients, synergistically contribute anti-oxidative stress, anti-inflammatory, neuroprotective, anti-apoptotic effects. demonstrated efficacy facilitating motor function recovery neuroprotection SCI rats, providing evidence future research. complex microenvironment SCI, achieving maximum loading capacity within biomaterials, along sustained controlled release fully exert pharmacological effects, remains major challenge https://www.crd.york.ac.uk/PROSPERO/ identifier CRD42024505000.

Язык: Английский

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In situ formulation of biomaterials for disease therapy: Recent advances in peptide assembly strategies

Coordination Chemistry Reviews, Год журнала: 2024, Номер 523, С. 216251 - 216251

Опубликована: Окт. 12, 2024

Язык: Английский

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Simultaneous Determination of the Position and Cis–Trans Configuration of Lipid C═C Bonds via Asymmetric Derivatization and Ion Mobility–Mass Spectrometry

Journal of the American Chemical Society, Год журнала: 2024, Номер 146(43), С. 29503 - 29512

Опубликована: Окт. 16, 2024

The position and cis–trans configuration of C═C bonds in unsaturated lipids significantly affect their biological activities. Simultaneous identification the is important; nonetheless, it still remains a challenging task. Herein, stereoselective asymmetric reaction was used to recognize isomers bonds, derivatized precursor ions product were subjected tandem ion mobility–mass spectrometry (IM–MS) analysis. theoretical calculation revealed that formation intramolecular hydrogen after cyclization amplified structural difference between diastereomers increased separation efficiency IM. Consequently, simple, sensitive, highly selective platform for simultaneous determination various established. It then successfully applied pinpoint geometry conversion located bacterial membrane under environmental stress track heterogeneous distribution rats spinal cord injury. present study also offers new insights into application IM–MS technology resolving molecular structures demonstrates potential as broad range applications.

Язык: Английский

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Acid Neutralization by Composite Lysine Nanoparticles for Spinal Cord Injury Recovery through Mitigating Mitochondrial Dysfunction

ACS Biomaterials Science & Engineering, Год журнала: 2024, Номер 10(7), С. 4480 - 4495

Опубликована: Июнь 17, 2024

After spinal cord injury (SCI), significant alterations in the tissue microenvironment lead to mitochondrial dysfunction, inducing apoptosis and inhibiting remodeling of neural circuits, thereby impeding recovery. Although previous studies have demonstrated a marked decrease pH at site, creating an acidic microenvironment, impact improving this on SCI recovery has not been investigated. This study prepared lysine@hollow mesoporous silica nanoparticle/gelatin methacrylate (GelMA) (L@H/G) composite hydrogel. The L@H/G hydrogel was release lysine efficiently improve slowly. Significantly, reduced cell apoptosis, promoted nerve regeneration, inhibited glial scar formation, ultimately enhanced motor function mice with SCI. Mechanistically, improved tricarboxylic acid (TCA) cycle fatty metabolism, restoring energy supply facilitating To best our knowledge, is first report confirming that could promote repair, providing potential therapeutic strategy for

Язык: Английский

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