Journal of Hematology & Oncology,
Год журнала:
2025,
Номер
18(1)
Опубликована: Апрель 17, 2025
In
situ
vaccination
(ISV)
has
emerged
as
a
promising
strategy
in
cancer
immunotherapy,
offering
targeted
approach
that
uses
the
tumor
microenvironment
(TME)
to
stimulate
an
immune
response
directly
at
site.
This
method
minimizes
systemic
exposure
while
maintaining
therapeutic
efficacy
and
enhancing
safety.
Recent
advances
nanotechnology
have
enabled
new
approaches
ISV
by
utilizing
nanomaterials
with
unique
properties,
including
enhanced
permeability,
retention,
controlled
drug
release.
employing
can
induce
immunogenic
cell
death
reverse
immunosuppressive
hypoxic
TME,
thereby
converting
"cold"
into
"hot"
facilitating
more
robust
response.
review
examines
mechanisms
through
which
nanomaterials-based
enhances
anti-tumor
immunity,
summarizes
clinical
applications
of
these
strategies,
evaluates
its
capacity
serve
neoadjuvant
therapy
for
eliminating
micrometastases
early-stage
patients.
Challenges
associated
translation
ISV,
nanomaterial
metabolism,
optimization
treatment
protocols,
integration
other
therapies
such
radiotherapy,
chemotherapy,
photothermal
therapy,
are
also
discussed.
Advances
immunotherapy
continue
expand
possible
potentially
leading
improved
outcomes
across
broad
range
types.
Journal of Nanobiotechnology,
Год журнала:
2025,
Номер
23(1)
Опубликована: Апрель 7, 2025
Abstract
Breast
cancer
is
the
most
commonly
diagnosed
worldwide.
Despite
advancements
in
therapeutic
modalities,
its
prognosis
remains
poor
owing
to
complex
clinical,
pathological,
and
molecular
characteristics.
Sonodynamic
therapy
(SDT)
a
promising
approach
for
tumor
elimination,
using
sonosensitizers
that
preferentially
accumulate
tissues
are
activated
by
low-intensity
ultrasound
produce
reactive
oxygen
species.
However,
clinical
translation
of
SDT
faces
challenges,
including
limited
efficiency
resistance
posed
microenvironment.
The
emergence
nanomedicine
offers
innovative
strategies
address
these
obstacles.
This
review
discusses
enhancing
efficacy
sonosensitizers,
rational
structural
modifications,
improved
tumor-targeted
enrichment,
microenvironment
remodeling,
imaging-guided
therapy.
Additionally,
SDT-based
multimodal
therapies,
such
as
sono-chemotherapy,
sono-immunotherapy,
sono-photodynamic
therapy,
their
potential
applications
breast
treatment
summarized.
underlying
mechanisms
briefly
outlined.
Finally,
this
highlights
current
challenges
prospects
SDT,
providing
insights
into
future
may
improve
outcomes
cancer.
Graphical
abstract
Advanced Healthcare Materials,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 9, 2025
Abstract
Melanoma
is
a
highly
aggressive
and
metastatic
tumor,
immunotherapy
has
become
the
current
solution.
However,
conventional
nanovaccines
do
not
strongly
activate
T
cell
immune
responses.
Therefore,
development
of
effective
therapeutic
to
systemic
antitumor
immunity
urgently
required.
Herein,
light/ultrasound
(US)
dual‐responsive
carbon
dot‐based
(Cu‐N‐CDs@OVA)
are
designed
using
copper‐nitrogen‐coordinated
dots
composited
with
ovalbumin.
Under
650‐nm
laser
irradiation,
Cu‐N‐CDs@OVA
exhibited
superior
photothermal
ablation
primary
tumors,
induced
immunogenic
death
released
antigens
by
phototherapy,
facilitating
maturation
dendritic
cells
(DCs).
More
importantly,
stably
penetrated
diffused
upon
US
treatment,
eradicating
tumors
generating
low‐dose
reactive
oxygen
species
DCs.
By
integrating
model
antigen
OVA,
combined
multimodal
treatment
promotes
DC
systematic
immunity.
This
first
example
light/US
nanovaccine
that
provides
paradigm
for
production
personalized
against
malignant
tumors.
ABSTRACT
Sonodynamic
therapy
(SDT)
is
an
innovative
cancer
modality
that
harnesses
the
energy
of
ultrasound
to
activate
sonosensitizers
for
producing
reactive
oxygen
species
(ROS),
culminating
in
eradication
tumor
cells.
Compared
with
photodynamic
therapy,
SDT
has
capacity
penetrate
deeply
into
biological
tissues,
thereby
holding
significant
promise
addressing
situated
or
surgically
inaccessible
tumors.
The
effectiveness
greatly
dependent
on
characteristics
sonosensitizers,
and
unlike
inorganic
organic
offer
a
more
controlled
synthesis
process
have
excellent
biocompatibility.
This
review
presents
meticulous
undertaking
categorize
elucidate
their
mechanisms
action
therapeutic
effects
context
SDT.
Design
strategies
are
also
summarized,
we
emphasize
critical
role
nanotechnology
localization,
imaging,
multimodal
synergistic
offering
approach
achieving
precise
targeting.
In
addition,
impact
delineated
when
integrated
other
oncological
modalities,
such
as
photothermal
enhance
efficacy.
Finally,
discusses
challenges
future
perspectives
advancement
clinical
within
realm
oncology.
Journal of Hematology & Oncology,
Год журнала:
2025,
Номер
18(1)
Опубликована: Апрель 17, 2025
In
situ
vaccination
(ISV)
has
emerged
as
a
promising
strategy
in
cancer
immunotherapy,
offering
targeted
approach
that
uses
the
tumor
microenvironment
(TME)
to
stimulate
an
immune
response
directly
at
site.
This
method
minimizes
systemic
exposure
while
maintaining
therapeutic
efficacy
and
enhancing
safety.
Recent
advances
nanotechnology
have
enabled
new
approaches
ISV
by
utilizing
nanomaterials
with
unique
properties,
including
enhanced
permeability,
retention,
controlled
drug
release.
employing
can
induce
immunogenic
cell
death
reverse
immunosuppressive
hypoxic
TME,
thereby
converting
"cold"
into
"hot"
facilitating
more
robust
response.
review
examines
mechanisms
through
which
nanomaterials-based
enhances
anti-tumor
immunity,
summarizes
clinical
applications
of
these
strategies,
evaluates
its
capacity
serve
neoadjuvant
therapy
for
eliminating
micrometastases
early-stage
patients.
Challenges
associated
translation
ISV,
nanomaterial
metabolism,
optimization
treatment
protocols,
integration
other
therapies
such
radiotherapy,
chemotherapy,
photothermal
therapy,
are
also
discussed.
Advances
immunotherapy
continue
expand
possible
potentially
leading
improved
outcomes
across
broad
range
types.
