BRD4 Degradation Enhanced Glioma Sensitivity to Temozolomide by Regulating Notch1 via Glu‐Modified GSH‐Responsive Nanoparticles

Advanced Science, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 15, 2024

Abstract Temozolomide (TMZ) serves as the principal chemotherapeutic agent for glioma; nonetheless, its therapeutic efficacy is compromised by rapid emergence of drug resistance, inadequate targeting glioma cells, and significant systemic toxicity. ARV‐825 may play a role in modulating resistance degrading BRD4 protein, thereby exerting anti‐glioma effects. Therefore, to surmount TMZ achieve efficient specific delivery, dual‐targeted glutathione (GSH)‐responsive nanoparticle system (T+A@Glu‐NP) designed synthesized co‐delivery TMZ. As anticipated, T+A@Glu‐NPs significantly enhanced penetration blood‐brain barrier (BBB), facilitated uptake exhibited accumulation brain tissue. Additionally, augmented against both vitro vivo through induction apoptosis, inhibition proliferation, cell cycle arrest. Furthermore, mechanistic exploration revealed that degraded leading downregulation Notch1 gene transcription signaling pathway, augmenting chemotherapy. Taken together, findings suggest represents novel promising strategy

Язык: Английский

Bioactive Materials Facilitate the Restoration of Neurological Function Post Cerebral Ischemic Stroke

International Journal of Nanomedicine, Год журнала: 2024, Номер Volume 19, С. 14171 - 14191

Опубликована: Дек. 1, 2024

Язык: Английский