Stepwise targeted strategies for improving neurological function by inhibiting oxidative stress levels and inflammation following ischemic stroke

Journal of Controlled Release, Год журнала: 2024, Номер 368, С. 607 - 622

Опубликована: Март 15, 2024

Язык: Английский

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Fabric‐Enhanced Vascular Graft with Hierarchical Structure for Promoting the Regeneration of Vascular Tissue

Advanced Healthcare Materials, Год журнала: 2024, Номер 13(16)

Опубликована: Янв. 27, 2024

Abstract Natural blood vessels have completed functions, including elasticity, compliance, and excellent antithrombotic properties because of their mature structure. To replace damaged vessels, vascular grafts should perform these functions by simulating the natural structures. Although structures are thoroughly explored, constructing a small‐diameter graft that matches mechanical biological remains challenge. A hierarchical is fabricated Electrospinning, Braiding, Thermally induced phase separation (EBT) processes, which could simulate structure vessels. The internal electrospun facilitates adhesion endothelial cells, thereby accelerating endothelialization. intermediate PLGA fabric exhibits properties, allow it to maintain its shape during long‐term transplantation prevent expansion. external macroporous beneficial for cell growth infiltration. Blood vessel remodeling aims combine promotes tissue regeneration with anti‐inflammatory materials. results in vitro demonstrated EBT (EBTVG) has matched reliable cytocompatibility, strongest endothelialization situ. replacement resected artery vivo suggest EBTVG combines different structural advantages biomechanical biocompatibility, significantly promoting stabilization cells smooth muscle as well stabilizing microenvironment.

Язык: Английский

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Generation and π-phase-induced oscillations of multi-soliton molecular complexes in ultrafast fiber lasers based on MOF-253@Au

Chemical Engineering Journal, Год журнала: 2025, Номер unknown, С. 159024 - 159024

Опубликована: Янв. 1, 2025

Язык: Английский

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Calcium crosslinked macroporous bacterial cellulose scaffolds with enhanced in situ mineralization and osteoinductivity for cranial bone regeneration

Composites Part B Engineering, Год журнала: 2024, Номер 275, С. 111277 - 111277

Опубликована: Фев. 13, 2024

Язык: Английский

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Durable immunomodulatory hierarchical patch for rotator cuff repairing

Bioactive Materials, Год журнала: 2024, Номер 37, С. 477 - 492

Опубликована: Апрель 25, 2024

Degradable rotator cuff patches, followed over five years, have been observed to exhibit high re-tear rates exceeding 50%, which is attributed the inability of degradable polymers alone restore post-rotator tear (RCT) inflammatory niche. Herein, poly(ester-ferulic acid-urethane)urea (PEFUU) was developed, featuring prolonged anti-inflammatory functionality, achieved by integration ferulic acid (FA) into polyurethane repeating units. PEFUU stably releases FA in vitro, reversing niche produced M1 macrophages and restoring directed differentiation stem cells. Utilizing PEFUU, hierarchical composite nanofiber patch (HCNP) fabricated, simulating natural microstructure tendon-to-bone interface with an aligned-random alignment. The incorporation enzymatic hydrolysate derived from decellularized Wharton jelly tissue random layer could further enhance cartilage regeneration at interface. Via rat RCT repairing model, HCNP possessing properties uniquely facilitated physiological healing interface's microstructure. alignment fibers restored, histologically, characteristic tripartite distribution collagen I - II achieved. This study offers a universal approach functionalization provides foundational reference for their future applications promoting vivo musculoskeletal tissues.

Язык: Английский

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Enhancing Infected Diabetic Wound Healing through Multifunctional Nanocomposite‐Loaded Microneedle Patch: Inducing Multiple Regenerative Sites

Advanced Healthcare Materials, Год журнала: 2024, Номер 13(20)

Опубликована: Май 22, 2024

Abstract Infected diabetic wound (DW) presents a prolonged and challenging healing process within the field of regenerative medicine. The effectiveness conventional drug therapies is hindered by their limited ability to reach deep tissues promote adequate rates. Therefore, there an imperative develop delivery systems that can penetrate while exhibiting multifunctional properties expedite healing. In this study, w e devised soluble microneedle (MN) patch made γ‐PGA, featuring multiple arrays, which as loaded with core‐shell structured nanoparticles (NPs) known Ag@MSN@CeO 2 , enhance infected DWs. NP comprises cerium dioxide (CeO ) core anti‐inflammatory antioxidant properties, mesoporous silica (MSN) shell angiogenic characteristics, outermost layer doped Ag combat bacterial infections. W demonstrated MN platform successfully penetrated for effective delivery. These tips induced formation sites at various points, leading antibacterial, reactive oxygen species‐lowering, macrophage ecological niche‐regulating, vascular regeneration‐promoting, collagen deposition‐promoting effects, thus significantly expediting Considering these findings, MN@Ag@MSN@CeO exhibits substantial potential clinical applications in treatment DW.

Язык: Английский

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Temperature-responsive self-contraction nanofiber/hydrogel composite dressing facilitates the healing of diabetic-infected wounds

Materials Today Bio, Год журнала: 2024, Номер 28, С. 101214 - 101214

Опубликована: Авг. 27, 2024

Bacterial infections and long-term inflammation cause serious secondary damage to chronic diabetic wounds hinder the wound healing processes. Currently, multifunctional hydrogels have shown promising effects in repair. However, traditional only keep moist protect it from bacterial infection, cannot provide mechanical force contract edges achieve facilitated closure. Here, an asymmetric composite dressing was created by combining biaxially oriented nanofibers hydrogel, inspired double-layer structure of Chinese medicinal plaster patch, for managing wounds. Specifically, electrospun Poly-(lactic acid-co-trimethylene carbonate) (PLATMC) methacrylate gelatin (GelMa) hydrogel loaded with Epinecidin-1@chitosan (Epi-1@CS) nanoparticles are assembled as temperature-responsive self-contracting nanofiber/hydrogel (TSNH) dressing. The substrate layer PLATMC combines topological morphology material properties drive closure through temperature-triggered contraction force. functional GelMa is Epi-1@CS that combine satisfactory cytocompatibility, antioxidant, anti-inflammatory, antibacterial properties. Strikingly,

Язык: Английский

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Recent Progress in Biomedical Scaffold Fabricated via Electrospinning: Design, Fabrication and Tissue Engineering Application

Advanced Functional Materials, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 26, 2024

Abstract Electrospinning is a significant manufacturing strategy to create micro/nanofiber platforms that can be considered biomedical scaffold for tissue engineering repair and regeneration. In recent years researchers have continuously broadened the equipment design materials development of electrospinning nanofiber (ENPs), which evolved from single‐needle multi‐needle creating 3D ENPs, diversify their application including drugs/cell/growth factors release, anti‐bacterial anti‐inflammatory, hemostasis, wound healing, Herein, multifunctional ENPs with bioactive polymer fabricated via in terms novel material design, construction various structures, requirements different regeneration are reviewed. Furthermore, this review delves into advancements facilitated by highlighting effectiveness versatility across types such as bone, cartilage, tendons, cardiac tissue, nerves. The discussion comprehensively addresses ongoing challenges selection, biodegradation mechanisms, bioactivation strategies, techniques specific applications. Moreover, outlines potential future research avenues aimed at enhancing ENPs‐based approaches engineering. This in‐depth analysis aims provide nuanced insights technical recommendations propel field forward

Язык: Английский

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Highly Bioadaptable Hybrid Conduits with Spatially Bidirectional Structure for Precision Nerve Fiber Regeneration via Gene Therapy

Advanced Science, Год журнала: 2024, Номер 11(19)

Опубликована: Март 14, 2024

Abstract Peripheral nerve deficits give rise to motor and sensory impairments within the limb. The clinical restoration of extensive segmental defects through autologous transplantation often encounters challenges such as axonal mismatch suboptimal functional recovery. These issues may stem from limited regenerative capacity proximal axons subsequent Wallerian degeneration distal axons. To achieve integration functions, a spatially differential plasmid DNA (pDNA) dual‐delivery nanohydrogel conduit scaffold is devised. This innovative facilitates localized administration transforming growth factor β (TGF‐β) gene in region accelerate regeneration, while simultaneously delivering nicotinamide mononucleotide adenylyltransferase 2 (NMNAT2) mitigate degeneration. By promoting autonomous selective alignment fiber gap sutures via structure design, approach aims harmonious unification neuromotor function, It anticipated that this groundbreaking technology will establish robust platform for delivery tissue engineering.

Язык: Английский

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Methacrylated Carboxymethyl Chitosan Scaffold Containing Icariin-Loaded Short Fibers for Antibacterial, Hemostasis, and Bone Regeneration

ACS Biomaterials Science & Engineering, Год журнала: 2024, Номер 10(8), С. 5181 - 5193

Опубликована: Июнь 27, 2024

Bone defects typically result in bone nonunion, delayed or nonhealing, and localized dysfunction, commonly used clinical treatments (i.e., autologous allogeneic grafts) have limited results. The multifunctional tissue engineering scaffold provides a new treatment for the repair of defects. Herein, three-dimensional porous composite with stable mechanical support, effective antibacterial hemostasis properties, ability to promote rapid was synthesized using methacrylated carboxymethyl chitosan icariin-loaded poly-l-lactide/gelatin short fibers (M-CMCS-SFs). Icariin-loaded SFs M-CMCS resulted sustained release osteogenic agents, which beneficial reinforcement. Both structure use facilitate absorption blood fluid exudates. Moreover, its superior properties could prevent occurrence inflammation infection. When cultured mesenchymal stem cells, showed promotion differentiation. Taken together, such comprehensive performance antibacterial, hemostasis, regeneration, thus holding promising potential related medical treatments.

Язык: Английский

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