Abstract
Nanozymes
have
been
widely
used
for
treating
reactive
oxygen
species
(ROS)
caused
diseases.
However,
the
ROS‐dependent
antibacterial
property
is
inevitably
damaged
during
process
of
scavenging
ROS,
which
unfavorable
treatment
diseases
related
to
both
ROS
accumulation
and
bacterial
infections.
To
address
issues,
biomedical
materials
with
ROS‐elimination
ability
ROS‐independent
capacity
are
fabricated
via
in
situ
depositing
spherical
Au
nanoparticles
(Au
NPs)
on
rough
surface
metal
organic
frameworks
composed
Ce(III)
terephthalic
acid
(Ce‐BDC@Au
MOFs).
The
synthesized
Ce‐BDC@Au
MOFs
show
multi‐enzymatic
activities
owing
reversible
conversion
between
Ce
3+
4+
,
can
significantly
scavenge
cells.
deposition
NPs
Ce‐BDC
causes
come
close
proximity
forming
plasmon
resonance
coupling,
inducing
wavelength
red
shifted
NIR
region.
Based
this,
good
photothermal
efficiency
under
laser
(808
nm)
irradiation.
Benefitting
from
ability,
high
against
staphylococcus
aureus
through
mechanically
damaging
destruction.
This
strategy
biosafety
effectiveness
Biomacromolecules,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 5, 2025
Diabetic
wound
healing
remains
a
significant
challenge
due
to
complex
pathological
mechanisms,
including
prolonged
inflammation,
excessive
reactive
oxygen
species
(ROS)
accumulation,
angiogenesis
dysfunction,
and
increased
susceptibility
bacterial
infection.
In
this
study,
we
developed
dual
ROS/glucose-responsive
quercetin-loaded
supramolecular
hydrogel
(GPQ
hydrogel)
for
treating
diabetic
wounds.
The
was
fabricated
by
incorporating
quercetin
(QUE)
into
guanosine–phenylboronic
acid
(GP)
network
through
dynamic
borate
ester
bonds.
Structural
characterization
revealed
the
formation
of
typical
G-quadruplex
structure
in
GPQ
hydrogel.
responsiveness
ROS
glucose
enabled
controlled
release
QUE,
effectively
addressing
abnormal
microenvironment
diabetes.
vitro
studies
demonstrated
excellent
antibacterial,
antioxidant,
anti-inflammatory,
pro-angiogenic
properties
Furthermore,
vivo
study
using
full-thickness
model
streptozotocin-induced
rats
showed
that
significantly
accelerated
closure,
enhanced
re-epithelialization
collagen
deposition,
promoted
compared
control
GP
groups.
Immunofluorescence
analysis
confirmed
superior
antioxidant
effects
microenvironment.
This
presents
promising
multifunctional
biomaterial
managing
Advanced Healthcare Materials,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 11, 2025
Abstract
The
hyperglycemic
microenvironment
of
diabetes
inevitably
leads
to
the
accumulated
reactive
oxygen
species
(ROS)
and
impairs
function
stem
cells,
thereby
impeding
process
osseointegration
after
implant
placement.
In
this
study,
a
self‐assembled
metal‐phenolic
nanozyme
coating
is
presented
for
alleviating
diabetic
oxidative
stress
improving
at
interfaces.
antioxidant‐like
enzyme
activity
induced
by
phenolic
ligand−metal
charge
transfer
(LMCT)
during
coordination
epigallocatechin‐3‐gallate
(EGCG)
with
copper
phosphate
nanosheets
(Cu
NS).
biointerfaces
exhibits
scavenging
against
range
free
radicals
facilitated
adhesion,
migration,
osteogenic
differentiation
enhancing
implants
in
rats.
Additionally,
strategy
inhibits
bacterial
invasion
supports
adhesion
soft
tissue
cells.
This
study
provides
prospective
approach
surface
modification
safeguard
enhance
subjects.
ACS Biomaterials Science & Engineering,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 23, 2025
This
study
aimed
to
investigate
the
effects
of
a
sustained-release
composite
containing
gelatin
methacryloyl
(Gel)
and
kaempferol
(Ka,
K)
on
experimental
periodontitis
symptoms
in
rats.
Forty
6-week-old
male
rats
were
randomly
assigned
four
treatment
groups
specific
pathogen-free
(SPF)
environment:
Control
group
(C),
model
(M),
Gel
alone
(G),
Gel_Ka
composite-treated
(G_K).
Treatment
periodontal
status
bilateral
maxillary
second
molars
each
rat
assessed
by
micro-CT
imaging
histology.
Immunohistochemistry
staining
was
employed
examine
expression
levels
inflammatory
factors
IL-6
MMP9
(associated
with
M1
macrophages)
anti-inflammatory
factor
CD206
M2
macrophages).
Additionally,
oral
intestinal
microbial
communities
analyzed
through
16S
rDNA
sequencing.
Local
injection
G_K
hydrogel
effectively
suppressed
alveolar
bone
resorption
reduced
attachment
loss
inflammation
infiltration
periodontitis.
It
but
increased
CD206,
it
also
abundance
gut
producing
short-chain
fatty
acids.
demonstrates
substantial
antiperiodontitis
effect
locally
attenuating
is
associated
enhancing
composition
flora,
thus
aiding
mitigating
progression
Effective
wound
management
demands
advanced
dressings
that
protect
while
actively
supporting
healing.
Traditional
often
fall
short
of
meeting
the
complex
needs
skin
repair.
Inspired
by
regenerative
abilities
starfish,
we
developed
a
bionically
engineered
hydrogel
designed
to
enhance
The
is
synthesized
through
coassembly
dopamine-modified
cellulose
nanofibers,
chitosan,
(3-aminobenzeneboronic
acid)-grafted
oxidized
dextran,
and
poly(vinyl
alcohol),
utilizing
dynamic
Schiff
base
boronic
ester
linkages.
This
innovative
design
imparts
multifunctional
properties,
including
injectability,
3D
printability,
antibacterial
activity,
self-adhesion,
self-healing,
antioxidant
protection,
hemostasis,
which
emulate
defense
mechanisms
processes
starfish.
These
characteristics
work
synergistically
reduce
infection
oxidative
stress
improve
healing
efficiency.
Additionally,
incorporates
mangiferin
Vitamin
C,
are
released
in
controlled
manner
response
wound's
microenvironment
(pH
reactive
oxygen
species),
promoting
tissue
regeneration
reducing
inflammation.
In
vitro
tests
confirmed
its
dual
responsiveness,
finite
element
modeling
validated
release
bioactive
compounds.
vivo
testing
on
rat
full-thickness
model
showed
100%
rate
day
13,
significantly
outperforming
commercial
alternatives.
hydrogel's
nontoxicity
capabilities
make
it
promising
solution
for
patients
with
critical
needs,
offering
comprehensive
integration
natural
biological
cutting-edge
engineering.
Advanced Functional Materials,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 24, 2025
Abstract
Pathological
microenvironment
of
diabetes
including
hyperglycemia,
excessive
reactive
oxygen
species
(ROS),
and
accumulation
advanced
glycation
end
products
leads
to
high
risk
infection
persistent
inflammatory
reaction,
retarding
biointegration
implants.
To
address
this
issue,
a
dual‐catalysis
system
consisting
Na
2
TiO
3
nanotubes
with
CeO
nanodots
polydopamine
(PDA)
cover
is
constructed
on
Ti
implant
manipulate
ROS
generation
scavenging
for
antibiosis
tissue
regeneration.
form
heterojunction,
in
which
vacancies
(VOs)
contribute
the
separation
electron‐hole
pairs
under
near‐infrared
light
(NIR)
irradiation.
In
NIR
mode,
photocatalysis‐induced
photothermal‐induced
hyperthermia
by
‐CeO
heterojunction
PDA
synergistically
kill
bacteria
efficiently.
non‐NIR
show
excellent
superoxide
dismutase
(SOD)
catalases
(CAT)
like
enzyme
activities,
they
catalyze
(e.g.,
·O
−
H
O
)
thoroughly
into
benign
O,
relieving
oxidative
stress
accelerating
M2
macrophage
phenotype.
It
helps
biofunctional
recovery
endothelial
cells
fibroblasts,
promoting
regeneration
around
implants
diabetic
models.
This
work
proposes
promising
approach
manipulating
treat
regulate
thereby
improving
performance
microenvironment.
Abstract
Wound
healing
is
a
dynamic
process
often
accompanied
by
bacterial
infection.
Bacterial
proliferation
and
induced
excessive
inflammation
hinder
the
in
infectious
wounds,
leading
to
refractory
wounds.
Addressing
challenges
of
wounds
requires
development
multifunctional
dressings
capable
eliminating
infection,
relieving
inflammation,
restoring
wound
microenvironment.
In
this
study,
Ag
+
‐ion
functionalized
Cu
2+
UiO‐67
metal‐organic
framework
(MOF‐Ag
MOF‐Cu)
are
incorporated
into
an
oxidized
dextran
gelatin
mixture
fabricate
hydrogel,
termed
as
OGAC.
The
resulting
OGAC
exhibited
injectable,
adhesive,
hemostatic,
antibacterial,
anti‐inflammatory
properties,
along
with
good
biocompatibility.
hydrogel
precursor
could
be
injected
situ
at
site
cover
wound,
serving
physical
barrier
protect
Moreover,
demonstrates
efficient
antibacterial
anti‐biofilm
activity,
against
both
Escherichia
coli
Staphylococcus
aureus
.
Additionally,
has
superoxide
dismutase‐like
glutathione
peroxidase‐like
activity
for
anti‐oxidation,
which
conducive
reduce
wound.
reveals
high
performance
infected
mouse
model.
These
findings
suggest
that
promising
candidate
multiple
functionalities
clinical
management.
