International Journal of Pharmaceutics, Год журнала: 2025, Номер unknown, С. 125548 - 125548
Опубликована: Апрель 1, 2025
Язык: Английский
International Journal of Pharmaceutics, Год журнала: 2025, Номер 670, С. 125186 - 125186
Опубликована: Янв. 8, 2025
The blood-brain barrier (BBB) plays a vital role in protecting the central nervous system (CNS) by preventing entry of harmful pathogens from bloodstream. However, this also presents significant obstacle when it comes to delivering drugs for treatment neurodegenerative diseases and brain cancer. Recent breakthroughs nanotechnology have paved way creation wide range nanoparticles (NPs) that can serve as carriers diagnosis therapy. Regarding their promising properties, organic NPs potential be used effective drug delivery across BBB based on recent advancements. These remarkable ability penetrate using various mechanisms. This review offers comprehensive examination intricate structure distinct properties BBB, emphasizing its crucial function preserving balance regulating transport ions molecules. disruption conditions such stroke, Alzheimer's disease, Parkinson's disease highlights importance developing creative approaches drugs. Through encapsulation therapeutic molecules precise targeting processes vasculature, NP formulations present hopeful strategy improve BBB. We explore changes pathological investigate factors affect successful into brain. In addition, we most systems associated with shown positive results treating ischemic disorders. opens up new possibilities nanotechnology-based therapies cerebral diseases.
Язык: Английский
Процитировано
5
European Journal of Medicinal Chemistry, Год журнала: 2025, Номер 287, С. 117357 - 117357
Опубликована: Фев. 5, 2025
Язык: Английский
Процитировано
5
Journal of Functional Biomaterials, Год журнала: 2025, Номер 16(1), С. 24 - 24
Опубликована: Янв. 14, 2025
Autoimmune diseases present complex therapeutic challenges due to their chronic nature, systemic impact, and requirement for precise immunomodulation avoid adverse side effects. Recent advancements in biodegradable stimuli-responsive nanomaterials have opened new avenues targeted drug delivery systems capable of addressing these challenges. This review provides a comprehensive analysis state-of-the-art nanocarriers such as polymeric nanoparticles, liposomes, hydrogels engineered autoimmune therapies. These are designed degrade safely the body while releasing agents response specific stimuli, including pH, temperature, redox conditions, enzymatic activity. By achieving localized controlled release anti-inflammatory immunosuppressive agents, minimize toxicity enhance efficacy. We discuss underlying mechanisms nanomaterials, recent applications treating rheumatoid arthritis, multiple sclerosis, inflammatory bowel disease, design considerations essential clinical translation. Additionally, we address current challenges, biocompatibility, scalability, regulatory hurdles, well future directions integrating advanced nanotechnology with personalized medicine treatment. highlights transformative potential presenting them promising strategy advance precision improve patient outcomes disease management.
Язык: Английский
Процитировано
2
Critical Reviews in Oncology/Hematology, Год журнала: 2025, Номер unknown, С. 104653 - 104653
Опубликована: Фев. 1, 2025
Язык: Английский
Процитировано
2
ACS Applied Nano Materials, Год журнала: 2024, Номер 7(15), С. 17151 - 17192
Опубликована: Июль 24, 2024
The advancement of precision medicine in modern biomedicine has been significantly propelled by the emergence micro/nanorobots. combination micro/nanorobots and offers unique advantages holds attractive potential for applications. It effectively addresses challenges encountered traditional robots areas such as driving, sensing, intelligence other aspects, especially application cancer cardiovascular diseases, which is a hot field interdisciplinary research recent years. This review succinctly delineates analyzes advancements First, achievements years are systematically classified introduced from four perspectives: manufacturing design, drive control, biomedical degradation. In particular, in-depth discussions were conducted regarding solutions each stage. Second, based on latest results applications, development direction industrial applications key technical aspects that need to be paid attention emphasized. Finally, we discuss opportunities future, it expected will become more sophisticated capable performing multiple medical functions tasks. They implemented vivo assist doctors diagnosing treating diseases. shows significant medicine.
Язык: Английский
Процитировано
10
Cancers, Год журнала: 2024, Номер 16(17), С. 2975 - 2975
Опубликована: Авг. 27, 2024
Malignant gliomas present great difficulties in treatment, with little change over the past 30 years median survival time of 15 months. Current treatment options include surgery, radiotherapy (RT), and chemotherapy. New therapies aimed at suppressing formation new vasculature (antiangiogenic treatments) or destroying formed tumor (vascular disrupting agents) show promise. This study summarizes existing knowledge regarding processes by which glioblastoma (GBM) tumors acquire resistance to antiangiogenic treatments. The discussion encompasses activation redundant proangiogenic pathways, heightened cell invasion metastasis, induced hypoxia, creation vascular mimicry channels, regulation immune microenvironment. Subsequently, we explore potential strategies overcome this resistance, such as combining other methods, personalizing treatments for each patient, focusing on therapeutic targets, incorporating immunotherapy, utilizing drug delivery systems based nanoparticles. Additionally, would like discuss limitations methods future directions enhance beneficial effects patients GBM. Therefore, review aims research outcome GBM provide a more promising opportunity thoroughly exploring mechanisms investigating novel strategies.
Язык: Английский
Процитировано
9
Materials Today Bio, Год журнала: 2025, Номер 31, С. 101457 - 101457
Опубликована: Янв. 5, 2025
Central nervous system (CNS) diseases are a major cause of disability and death worldwide. Due to the blood-brain barrier (BBB), drug delivery for CNS is extremely challenging. Nano-delivery systems can overcome limitations BBB deliver drugs CNS, improve ability target brain provide potential therapeutic methods diseases. At same time, choice different (bypassing or crossing BBB) further optimize effect nano-drug system. This article reviews nano-delivery way enters brain. Different kinds nanoparticles were discussed in depth.
Язык: Английский
Процитировано
1
Science Advances, Год журнала: 2025, Номер 11(3)
Опубликована: Янв. 15, 2025
Intracranial optical imaging of glioblastoma (GBM) is challenging due to the scarcity effective probes with blood-brain barrier (BBB) permeability and sufficient depth. Herein, we describe a rational strategy for designing crossing BBB based on an electron donor-π-acceptor system adjust lipid/water partition coefficient molecular weight probes. The amphiphilic hemicyanine dye (namely, IVTPO), which exhibits remarkable properties permeability, chosen as efficient fluorescence/photoacoustic probe in vivo real-time orthotopic GBM high resolution through intact skull. Abnormal leakage IVTPO adjacent developing tumor unambiguously observed at early stage development prior impairment integrity, assessed by commercial Evans blue (EB). Compared EB, demonstrates enhanced capability improved tumor-targeting efficacy. These results offer encouraging insights into medical diagnosis intracranial GBM.
Язык: Английский
Процитировано
1
Journal of Nanobiotechnology, Год журнала: 2025, Номер 23(1)
Опубликована: Фев. 26, 2025
Abstract The central nervous system (CNS) diseases are major contributors to death and disability worldwide. However, the blood–brain barrier (BBB) often prevents drugs intended for CNS from effectively crossing into brain parenchyma deliver their therapeutic effects. is a semi-permeable with high selectivity. BBB primarily manages transport of substances between blood CNS. To enhance drug delivery disease treatment, various brain-based strategies overcoming have been developed. Among them, nanoparticles (NPs) emphasized due multiple excellent properties. This review starts an overview BBB’s anatomical structure physiological roles, then explores mechanisms, both endogenous exogenous, that facilitate NP passage across BBB. text also delves how nanoparticles' shape, charge, size, surface ligands affect ability cross offers different nanoparticle classifications. concludes examination current challenges in utilizing nanomaterials discusses corresponding directions solutions. aims propose innovative diagnostic approaches design more effective Graphical abstract
Язык: Английский
Процитировано
1
Journal of Nanobiotechnology, Год журнала: 2024, Номер 22(1)
Опубликована: Июнь 8, 2024
Abstract Mitochondria occupy a central role in the biology of most eukaryotic cells, functioning as hub oxidative metabolism where sugars, fats, and amino acids are ultimately oxidized to release energy. This crucial function fuels variety cellular activities. Disruption mitochondrial is common feature many diseases, including cancer, neurodegenerative conditions cardiovascular diseases. Targeting tumor cell with multifunctional nanosystems emerges promising strategy for enhancing therapeutic efficacy against cancer. review comprehensively outlines pathways metabolism, emphasizing their critical roles energy production metabolic regulation. The associations between aberrant initiation progression cancer highlighted, illustrating how these disruptions contribute oncogenesis sustainability. More importantly, innovative strategies employing nanomedicines precisely target therapy fully explored. Furthermore, key challenges future directions this field identified discussed. Collectively, provides comprehensive understanding current state potential nanomedicine targeting offering insights developing more effective therapies.
Язык: Английский
Процитировано
7