ACS Nano,
Год журнала:
2024,
Номер
18(52), С. 35310 - 35324
Опубликована: Дек. 16, 2024
The
development
of
effective
oral
drug
delivery
systems
for
targeted
gut-to-liver
transport
remains
a
significant
challenge
due
to
the
multiple
biological
barriers
including
harsh
gastrointestinal
tract
(GIT)
environment
and
complex
protein
corona
(PC)
formation.
In
this
study,
we
developed
ligand-modified
nanoparticles
(NPs)
that
enable
by
crossing
GIT
attenuating
PC
Specifically,
mesoporous
silica
(MSNs)
were
functionalized
with
peptides
targeting
neonatal
Fc
receptor
(FcRn),
capitalizing
on
FcRn
expression
in
small
intestine
liver
delivery.
We
showed
MSNs
decorated
cyclic
binding
peptide
(MSNs-FcBP)
obtained
enhanced
diffusion
intestinal
mucus
superior
transportation
across
compared
unmodified
large
IgG
fragment
(MSNs-Fc),
which
correlated
diminished
adsorption
weaker
interaction
mucin.
After
entering
blood
circulation,
reduced
serum
formation
MSNs-FcBP
reduces
proteolytic
phagocytic
propensity
reticuloendothelial
system,
ultimately
ameliorating
accumulation
hepatocytes.
Pharmacokinetic
pharmacodynamic
studies
diabetic
mice
revealed
effectively
transported
therapeutic
agent
exenatide
epithelium,
leading
hypoglycemic
response
improved
glucose
tolerance.
This
study
underscores
critical
role
ligand
selection
limiting
formation,
thereby
significantly
enhancing
increasing
permeation
minimizing
serum-protein
interactions.
illustrates
potential
strategy
optimize
bioavailability
efficacy.
Acta Pharmaceutica Sinica B,
Год журнала:
2024,
Номер
14(9), С. 3876 - 3900
Опубликована: Июнь 22, 2024
Despite
the
promising
prospects
of
nanoparticles
in
oral
drug
delivery,
process
administration
involves
a
complex
transportation
pathway
that
includes
cellular
uptake,
intracellular
trafficking,
and
exocytosis
by
intestinal
epithelial
cells,
which
are
necessary
steps
for
to
enter
bloodstream
exert
therapeutic
effects.
Current
researchers
have
identified
several
crucial
factors
regulate
interaction
between
including
surface
properties
such
as
ligand
modification,
charge,
hydrophilicity/hydrophobicity,
protein
corona
formation,
well
holistic
like
particle
size,
shape,
rigidity.
Understanding
these
is
essential
enhancing
transepithelial
transport
efficiency
designing
effective
delivery
systems.
Therefore,
this
review
provides
comprehensive
overview
influence
nanoparticles,
elucidating
underlying
principles
governing
their
impact
on
transport.
The
also
outlines
chosen
parameters
be
considered
subsequent
design
ACS Pharmacology & Translational Science,
Год журнала:
2024,
Номер
7(4), С. 967 - 990
Опубликована: Март 19, 2024
Precision
medicine
is
transforming
colorectal
cancer
treatment
through
the
integration
of
advanced
technologies
and
biomarkers,
enhancing
personalized
effective
disease
management.
Identification
key
driver
mutations
molecular
profiling
have
deepened
our
comprehension
genetic
alterations
in
cancer,
facilitating
targeted
therapy
immunotherapy
selection.
Biomarkers
such
as
microsatellite
instability
(MSI)
DNA
mismatch
repair
deficiency
(dMMR)
guide
decisions,
opening
avenues
for
immunotherapy.
Emerging
liquid
biopsies,
artificial
intelligence,
machine
learning
promise
to
revolutionize
early
detection,
monitoring,
selection
precision
medicine.
Despite
these
advancements,
ethical
regulatory
challenges,
including
equitable
access
data
privacy,
emphasize
importance
responsible
implementation.
The
dynamic
nature
with
its
tumor
heterogeneity
clonal
evolution,
underscores
necessity
adaptive
strategies.
future
lies
potential
enhance
patient
care,
clinical
outcomes,
understanding
this
intricate
disease,
marked
by
ongoing
evolution
field.
current
reviews
focus
on
providing
in-depth
knowledge
various
diverse
approaches
utilized
against
at
both
biochemical
levels.
ACS Applied Materials & Interfaces,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 16, 2025
The
development
of
lanthanide-doped
upconversion
nanoparticle
(UCNP)-based
imaging
with
minimal
autofluorescence
and
improved
penetration
depth
is
important
in
medical
applications.
Exogenous
nanocarriers
readily
adsorb
plasma
proteins
following
intravenous
administration
(<0.5
min),
resulting
the
formation
a
protein
corona
on
fixed
surface.
facilitates
UCNP
interception
by
immune
system,
preventing
targeted
delivery
to
disease
sites.
In
this
study,
we
report
novel
surface-camouflaging
strategy
using
lanthanide
hydroxyl
carbonate
that
slowly
dissolved
physiological
phosphate
serum.
"self-consuming"
inorganic-shell-modified
UCNPs
(denoted
as
UCSP-PEG)
effectively
reduce
adhesion
more
than
90%
through
dissociation
effect
associated
amphiphilic
poly(ethylene
glycol)
(PEG)-modified
determined
an
ex
vivo
assay.
UCSP-PEG
exhibits
prolonged
blood
circulation
time
(t1/2
=
73.9
±
9.5
185
times
camouflage
materials
without
"stealth"
feature,
can
employ
upconverted
luminescence
(UCL)
monitor
tumor-related
vessels
for
at
least
120
min.
Based
superior
optical
properties
UCSP-PEG,
application
UCL
dual-channel
stereoscope
magnification
system
has
enabled
observation
capillaries
high
resolution,
offering
powerful
tool
monitoring
biological
activities
fine
tissue
level.
This
work
provides
nanovehicle,
resisting
based
significantly
advance
target-specific
cancer
diagnosis.
Nano Letters,
Год журнала:
2024,
Номер
24(45), С. 14337 - 14345
Опубликована: Окт. 29, 2024
Nanomaterials
with
peroxidase-like
activity
and
photothermal
conversion
efficiency
have
garnered
significant
attention
for
their
ability
to
generate
cytotoxic
hydroxyl
radicals
provide
synergistic
therapeutic
effects.
Selecting
nanozymes
suitable
properties
carriers
is
crucial
maximizing
efficacy.
While
the
mucin
family
known
its
mucoadhesive,
glycosylated
structures
that
enhance
drug
bioavailability
targeting,
potential
in
remains
underexplored.
Here,
we
utilize
mucin-2
facilitate
osmium
nanoclusters
(Os@Mucin),
creating
protein-corona-like
nanozymes.
This
configuration
bestows
Os@Mucin
excellent
(769
U/mg)
(22.83%,
808
nm).
Mucin-2
promotes
Os
uptake
by
cells,
allowing
exhibit
tumor
environment-responsive
activity,
further
enhanced
under
conditions
targeted
cytotoxicity
Advanced Therapeutics,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 19, 2025
Abstract
Inflammatory
bowel
disease
(IBD)
is
a
complex
chronic
inflammatory
disorder
of
the
gastrointestinal
(GI)
tract
with
an
uncertain
etiology.
Currently,
IBD
therapy
relies
on
induction
clinical
remission
followed
by
maintenance
using
anti‐inflammatory
drugs
and
immunosuppressants;
however,
definite
cure
still
out
scope.
Established
approaches
are
characterized
adverse
drug‐related
side
effects
that
can
even
be
potentially
life‐threatening.
In
contrast,
increased
interest
remarkable
scientific
progress
in
targeted
drug
delivery
systems
offer
promising
approach
to
reduce
systemic
events,
delivering
therapeutic
substances
only
inflamed
tissue.
All
alteration
barrier
integrity,
especially
disturbed
epithelial
barrier,
unique
pattern
receptors
cell
surface
and/or
oxidative
stress
milieu
areas
used
as
effective
for
controlled
delivery.
Hence,
this
review
focuses
pathophysiology
GI
potential
strategy
polymeric
nanoparticles
treatment.
Interdisciplinary
efforts
between
chemistry
gastroenterology/immunology
promise
create
novel
synergies
improve
development
nanoparticle
significant
impact.
regard,
current
challenges
translation
nanomedicine
also
discussed.
Journal of Agricultural and Food Chemistry,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 7, 2025
Biomacromolecules
in
physiological
environments
would
adsorb
onto
the
nanoparticles
(NPs)
to
form
corona
layers,
which
protein
coronas
(PCs)
are
major
constituent.
PCs
always
play
diverse
influences
on
fate
of
NPs
vitro
and
vivo,
especially
for
active-targeting
(e.g.,
transferrin-modified
nanoparticles,
Tf-NP).
In
order
eliminate
inhibition
efficiency
Tf-NP,
precoated
Tf-NP
with
bovine
serum
albumin
(BSA,
B@Tf-NP)
was
designed
fabricate
an
"active
PCs"
(PCs
formed
by
artificial
modification)
against
"passive
biological
environments),
inspired
formation
pattern
PCs.
The
results
indicated
that
B@Tf-NP
had
similar
particle
size,
dispersion,
physical
stability
Tf-NP.
Surprisingly,
enhanced
cellular
uptake
enterocytes
permeability
intestinal
tract
mice.
Notably,
concentration
ratio
BSA
Tf
could
ensure
revealed
timely
during
interacted
process
considered
be
appropriate.
These
findings
provide
easy
while
efficient
design
platform
overcome
biomacromolecular
barrier
oral
administration.
Advanced Functional Materials,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 6, 2025
Abstract
Transarterial
chemoembolization
(TACE)
is
considered
the
main
treatment
for
intermediate
and
advanced
liver
cancer.
Nevertheless,
TACE
may
aggravate
fibrosis
in
these
patients,
which
could
affect
therapeutic
effect
after
TACE.
Pirfenidone
(PFD)
exhibits
significant
antifibrotic
effects
liver,
primarily
via
inhibition
of
hepatic
stellate
cells
(HSCs)
activation.
However,
owing
to
high
dose
required
effective
treatment,
oral
administration
PFD
associated
with
several
side
effects.
This
study
introduces
an
folic
acid
(FA)‐modified
protein‐polysaccharide
nanoemulsion
designed
treat
post‐TACE
targeting.
novel
withstands
gastrointestinal
digestion
ensures
stability
PFD.
Furthermore,
this
improves
intestinal
permeability
efficacy
at
a
lower
folate
receptors
expressed
on
both
epithelial
activated
HSCs.
In
conclusion,
FA‐modified
presents
promising
approach
delivery
effectively
ameliorate
Abstract
The
utilization
of
plant‐derived
exosome‐like
nanovesicles
(ELNs)
as
nanocarriers
for
oral
delivery
bioactives
has
garnered
significant
attention.
However,
their
distinctive
lipid
membrane
composition
may
result
in
elevated
permeability
within
the
gastrointestinal
environment,
leading
to
leakage
carried
bioactives.
Inspired
by
concept
projectile
design,
Tartary
buckwheat‐derived
ELNs
(TB‐ELNs)
based
dual‐carriers
are
fabricated
loading
chlorogenic
acid
(CGA)
into
cores
and
bonding
selenium
nanoparticles
(SeNPs)
membrane.
results
indicate
that
SeNPs
bond
markedly
augments
rigidity,
therefore
enhances
stability
TB‐ELNs
retention
rate
loaded
CGA
during
digestion.
In
vitro
vivo
studies
indicates
internalized
epithelial
cells
transcytosis
via
endoplasmic
reticulum,
show
synergistic
regulatory
effect
on
high‐fat
diet‐induced
hyperglycemia
intestine‐liver
axis.
These
be
attributed
fact
combination
reduces
degradation
Moreover,
with
antioxidant
property
can
protect
from
oxidative
damage,
thereby
enhancing
biological
activities.
Collectively,
this
study
offers
a
new
strategy
develop
highly
efficient
systems
alleviate
diabetes.
