Cadmium Induces Spontaneous Abortion by Impairing Endometrial Stromal Cell Decidualization

Toxicology, Год журнала: 2025, Номер 511, С. 154069 - 154069

Опубликована: Янв. 30, 2025

Язык: Английский

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Unveiling the effects of micro and nano plastics in embryonic development

Toxicology Reports, Год журнала: 2025, Номер 14, С. 101954 - 101954

Опубликована: Фев. 20, 2025

The improper disposal and degradation of plastics causes the formation spread micro nano-sized plastic particles in ecosystem. widespread presence these nanoplastics leads to their accumulation biotic abiotic components environment, thereby affecting cellular metabolic functions organisms. Despite being classified as xenobiotic agents, information about sources exposure related reproductive health is limited. Micro nano during early developmental stages can cause abnormal embryonic development. It trigger neurotoxicity inflammatory responses well developing embryo. In development, a comprehensive study role pluripotency, gastrulation, multi-differentiation potential scarce. Due ethical concerns associated with direct use human embryos, pluripotent cells its 3D vitro models (with cell lines) are an alternative source for effective research. Thus, Embryoid body (EB) model provides platform conducting embryotoxicity Pluripotent stem such induced derived embryoid bodies (EBs) serve robust that mimics characteristics similar embryos. EB Accordingly, this review discusses significance Further, we also evaluated possible sources/routes microplastic generation analyzed surface chemistry cytotoxic effects reported till date.

Язык: Английский

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Exposure of the human placental primary cells to nanoplastics induces cytotoxic effects, an inflammatory response and endocrine disruption

Journal of Hazardous Materials, Год журнала: 2025, Номер 490, С. 137713 - 137713

Опубликована: Фев. 26, 2025

Humans are inevitably exposed to micro- and nanoplastics (MP/NP). These particles able cross the biological barriers enter bloodstream with levels close 1.6 µg mL-1; MP/NP have been detected in placentas meconium of newborns. However, consequences this exposure on integrity, development functions human placenta not documented. In study, trophoblasts purified from at term were for 48 h, two different sizes polystyrene nanoparticles (PS-NP) 20 nm (PS-NP20) 100 (PS-NP100), environmental supra-environmental concentrations (0.01-100 mL-1). Cell viability, oxidative stress, mitochondrial dynamics, lysosomal degradation processes, autophagy, inflammation/oxidative responses placental endocrine angiogenic assessed. PS-NP size determines their internalization rate behavior trophoblasts. Indeed, PS-NP20 more rapidly translocated, accumulated lysosomes as shown by confocal TEM imaging. They induce higher cytotoxicity than PS-NP100, early 1 mL-1 (p < 0.05). addition, they a pro-inflammatory cytokines response: IL-1ß is induced 0.01 both nanoparticle sizes; IL-6, TNF-α overexpressed only For first time, we report that disrupt function, observed decreased hCG release found blood. This work, provides an in-depth vitro assessment effects placenta.

Язык: Английский

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Micro-nanoplastics pollution and mammalian fertility: a systematic review and meta-analysis

Theriogenology, Год журнала: 2025, Номер 238, С. 117369 - 117369

Опубликована: Фев. 26, 2025

Язык: Английский

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Exposure to Polystyrene Nanoplastics Compromise Ovarian Reserve Function and Endometrial Decidualization in Early Pregnant Mice

Journal of Applied Toxicology, Год журнала: 2025, Номер unknown

Опубликована: Фев. 25, 2025

ABSTRACT In the environment, nanoplastics (NPs) have been shown to adversely impact reproductive health, yet research on their effects during early pregnancy is scarce. This study investigated of NPs endometrial decidualization in pregnant mice and fertility. Female were administered polystyrene (PS‐NPs) orally for 90 days before pregnancy. Our findings indicated that PS‐NPs exposure decreased live birth rate neonatal crown‐rump length. Decreased embryo implantation sites uterine wet weight observed post exposure. Histological examination revealed structural defects uteri a significant reduction follicular count across all stages PS‐NPs‐treated groups. Serum levels estradiol (E 2 ) progesterone (P) elevated, while follicle‐stimulating hormone (FSH) luteinizing (LH) diminished post‐exposure. Additionally, upregulated expression marker HOXA10 decidua. conclusion, our results suggest may disrupt disruption likely due perturbation hormonal balance within hypothalamic–pituitary–ovary including FSH, LH, E , P levels. These alterations arrest development, consequently leading detrimental outcomes compromised conditions. provided new perspective understanding possible microplastics female

Язык: Английский

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Gestational exposure to nanoplastics disrupts fetal development by promoting the placental aging via ferroptosis of syncytiotrophoblast

Environment International, Год журнала: 2025, Номер 197, С. 109361 - 109361

Опубликована: Март 1, 2025

Micro(nano)plastics (MNPs), are emerging environmental pollutants that have garnered widespread attention. Epidemiological and animal studies shown MNPs exposure during pregnancy is associated with adverse outcomes, such as intrauterine growth restriction (IUGR) miscarriage. However, the underlying mechanisms remain poorly understood. In this study, we found to a high dose (1 μg·mL-1) of 100 nm polystyrene nanoparticles (NPs) from gestational day (GD) 0 GD17 significantly decreased fetal weight increased number resorptions compared control group. Moreover, was lower in high-dose group than low-dose (0.1 Meanwhile, ferroptosis senescence were observed placentas mice exposed NPs. vitro experiments using human syncytiotrophoblast (STB) cells differentiated BeWo cells, NPs caused STB cells. Subsequent investigations revealed inhibition signaling by ferrostain-1 (Fer-1) or deferiprone (DFP) ameliorated induced Furthermore, alleviating placental Fer-1 improves loss mice. Taken together, our results demonstrated activated pathway STB, resulting which may attribute NPs-induced IUGR. This study not only elucidated mechanistic link between outcomes but also highlighted necessity for targeted interventions protect health, underscoring broader implications public health policy.

Язык: Английский

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Migrasomes, critical players in intercellular communication

Cancer Cell International, Год журнала: 2025, Номер 25(1)

Опубликована: Март 25, 2025

Migrasomes are a newly discovered type of extracellular vesicle (EV) formed during cell migration, playing pivotal role in intercellular communication. These vesicles generated by retracting fibers migrating cells and encapsulate various molecules, such as proteins, lipids, RNA, allowing the transfer biochemical signals to neighboring cells. Current evidence suggests that migrasomes involved wide range physiological processes embryogenesis, angiogenesis, immune modulation, mitochondrial quality control. Moreover, implicated pathological conditions, including cancer metastasis, cardiovascular diseases, viral infections. To fully understand their significance, it is critical first explore molecular mechanisms underlying formation function. Recent studies have shed light on biogenesis, release, biological properties migrasomes, all which key understanding cell-to-cell In this review, we provide an up-to-date summary migrasome characterization, activities communication, while also proposing potential new functions for these vesicles.

Язык: Английский

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Dicyclohexyl Phthalate derails trophoblast function and lipid metabolism through NDRG1 by targeting PPARα: RXRα

Toxicology, Год журнала: 2025, Номер unknown, С. 154124 - 154124

Опубликована: Март 1, 2025

Язык: Английский

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Subchronic Exposure to Polystyrene Nanoplastics Disrupts Placental Development and Calcium Homeostasis: Insights from In Vivo and In Vitro Models

ACS Nano, Год журнала: 2025, Номер unknown

Опубликована: Апрель 2, 2025

Nanoplastics have recently emerged as persistent pollutants of global concern that pose substantial risks to human health. However, the long-term adverse effects nanoplastics on female reproductive system remain unclear. Polystyrene (PS-NPs; 50 nm diameter) were selected representative nanosized plastic particles investigate potential subchronic prenatal and gestational exposure via drinking water placental development in ICR (CD-1) mice. Maternal 10 mg/L PS-NPs induced an increase fetal resorption rate significantly increased weight. Further observation morphology showed led aberrant structure damaged trophoblast cells. At cellular level, promoted proliferation, migration, invasion HTR-8/SVneo Mechanistically, transcriptomic proteomic analyses revealed triggered calcium disturbances upregulated Stam2 expression STAM2 by mediates disruption trophoblastic homeostasis regulates cell functions disturbing lysosomal degradation channel protein IP3R3 promoting intracellular inflow increasing level TRPV6 Therefore, our results indicated dyshomeostasis is main mechanism which induces abnormal development. These findings reveal a link between damage elucidate underlying molecular mechanism, providing evidence for environmental triggers pregnancy highlighting risk products pregnant women.

Язык: Английский

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Autophagy: a double-edged sword in ischemia–reperfusion injury

Cellular & Molecular Biology Letters, Год журнала: 2025, Номер 30(1)

Опубликована: Апрель 7, 2025

Abstract Ischemia–reperfusion (I/R) injury describes the pathological process wherein tissue damage, initially caused by insufficient blood supply (ischemia), is exacerbated upon restoration of flow (reperfusion). This phenomenon can lead to irreversible damage and commonly observed in contexts such as cardiac surgery stroke, where temporarily obstructed. During ischemic conditions, anaerobic metabolism tissues organs results compromised enzyme activity. Subsequent reperfusion exacerbates mitochondrial dysfunction, leading increased oxidative stress accumulation reactive oxygen species (ROS). cascade ultimately triggers cell death through mechanisms autophagy mitophagy. Autophagy constitutes a crucial catabolic mechanism within eukaryotic cells, facilitating degradation recycling damaged, aged, or superfluous organelles proteins via lysosomal pathway. essential for maintaining cellular homeostasis adapting diverse conditions. As self-degradation clearance mechanism, exhibits dualistic function: it confer protection during initial phases injury, yet potentially exacerbate later stages. paper aims elucidate fundamental I/R highlighting its dual role regulation effects on both organ-specific systemic responses. By comprehending their implications organ function, this study seeks explore potential therapeutic interventions modulation clinical settings.

Язык: Английский

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