Advanced technology in neuroscience .,
Год журнала:
2024,
Номер
1(2), С. 244 - 260
Опубликована: Ноя. 27, 2024
Nerve
injury
often
leads
to
degeneration
or
necrosis
of
damaged
nerve
cells,
which
can
result
in
regeneration
disorders
during
the
repair
process.
Promoting
is
a
critical
challenge
treatment
nervous
system
diseases.
With
rapid
advancements
related
research,
chemical
materials
have
shown
significant
promise
facilitating
because
their
excellent
biocompatibility
and
degradability.
The
use
tissue-engineered
material
scaffolds
provide
physical
channels
for
regeneration.
These
create
optimal
conditions
cell
growth
migration
effectively
regulate
physiological
processes
repair.
Therefore,
wide
range
applications
field
This
review
highlights
technological
tools
available
involving
materials.
(1)
Conductive
hydrogels:
Novel
conductive
hydrogels
been
developed
by
integrating
such
as
graphene,
carbon
nanotubes,
polypyrrole,
promote
functional
recovery
cells
through
electrical
stimulation.
(2)
Three-dimensional
printing:
printing
technology
contributes
precise
control
shape,
porosity
degradation
rate
scaffolds,
providing
customized
microenvironment
(3)
Nanomaterials:
unique
physicochemical
properties
nanoparticles
nanofibers
give
them
great
potential
penetrate
blood‒brain
barrier,
guide
targeted
drug
delivery.
(4)
Local
release
bioactive
molecules:
Through
design
materials,
controlled
molecules
factor,
brain-derived
neurotrophic
factor
fibroblast
has
realized,
promotes
(5)
Photothermal
photoacoustic
stimulation:
combination
photothermal
technologies
led
development
capable
responding
photostimulation,
new
avenues
noninvasive
neurostimulation.
engineering
are
highly
effective
promoting
significantly
improve
efficiency
quality
In
clinical
practice,
these
techniques
expected
more
strategies
patients
with
injuries,
improving
function
life.
also
discusses
detail
different
biocompatibility,
mechanical
strength,
degradability,
A
variety
neural
tissue
scaffold
techniques,
including
provision
support,
molecules,
direct
interaction
cells.
Although
show
potential,
several
challenges,
long-term
stability,
individual
variation
response,
large-scale
production,
still
need
be
addressed
before
they
translated
into
applications.
addition,
comprehensive
assessment
safety
efficacy
focus
future
research.
Future
research
will
on
optimizing
conducting
trials
validate
techniques.
Bioactive Materials,
Год журнала:
2024,
Номер
38, С. 1 - 30
Опубликована: Апрель 23, 2024
Characterized
by
their
pivotal
roles
in
cell-to-cell
communication,
cell
proliferation,
and
immune
regulation
during
tissue
repair,
exosomes
have
emerged
as
a
promising
avenue
for
"cell-free
therapy"
clinical
applications.
Hydrogels,
possessing
commendable
biocompatibility,
degradability,
adjustability,
physical
properties
akin
to
biological
tissues,
also
found
extensive
utility
engineering
regenerative
repair.
The
synergistic
combination
of
hydrogels
holds
the
potential
not
only
enhance
efficiency
but
collaboratively
advance
repair
process.
This
review
has
summarized
advancements
made
over
past
decade
research
hydrogel-exosome
systems
regenerating
various
tissues
including
skin,
bone,
cartilage,
nerves
tendons,
with
focus
on
methods
encapsulating
releasing
within
hydrogels.
It
critically
examined
gaps
limitations
current
research,
whilst
proposed
future
directions
applications
this
innovative
approach.
Military Medical Research,
Год журнала:
2025,
Номер
12(1)
Опубликована: Март 3, 2025
Abstract
Bone
tissue
relies
on
the
intricate
interplay
between
blood
vessels
and
nerve
fibers,
both
are
essential
for
many
physiological
pathological
processes
of
skeletal
system.
Blood
provide
necessary
oxygen
nutrients
to
bone
tissues,
remove
metabolic
waste.
Concomitantly,
fibers
precede
during
growth,
promote
vascularization,
influence
cells
by
secreting
neurotransmitters
stimulate
osteogenesis.
Despite
critical
roles
components,
current
biomaterials
generally
focus
enhancing
intraosseous
vessel
repair,
while
often
neglecting
contribution
nerves.
Understanding
distribution
main
functions
in
is
crucial
developing
effective
engineering.
This
review
first
explores
anatomy
highlighting
their
vital
embryonic
development,
metabolism,
repair.
It
covers
innovative
regeneration
strategies
directed
at
accelerating
intrabony
neurovascular
system
over
past
10
years.
The
issues
covered
included
material
properties
(stiffness,
surface
topography,
pore
structures,
conductivity,
piezoelectricity)
acellular
biological
factors
[neurotrophins,
peptides,
ribonucleic
acids
(RNAs),
inorganic
ions,
exosomes].
Major
challenges
encountered
neurovascularized
materials
clinical
translation
have
also
been
highlighted.
Furthermore,
discusses
future
research
directions
potential
developments
aimed
producing
repair
that
more
accurately
mimic
natural
healing
tissue.
will
serve
as
a
valuable
reference
researchers
clinicians
novel
into
practice.
By
bridging
gap
experimental
practical
application,
these
advancements
transform
treatment
defects
significantly
improve
quality
life
patients
with
bone-related
conditions.
International Journal of Nanomedicine,
Год журнала:
2024,
Номер
Volume 19, С. 4279 - 4295
Опубликована: Май 1, 2024
Ischemic
stroke,
being
a
prominent
contributor
to
global
disability
and
mortality,
lacks
an
efficacious
therapeutic
approach
in
current
clinical
settings.
Neural
stem
cells
(NSCs)
are
type
of
cell
that
only
found
inside
the
nervous
system.
These
can
differentiate
into
various
kinds
cells,
potentially
regenerating
or
restoring
neural
networks
within
areas
brain
have
been
destroyed.
This
review
begins
by
providing
introduction
existing
approaches
for
ischemic
followed
examination
promise
limits
associated
with
utilization
NSCs
treatment
stroke.
Subsequently,
comprehensive
overview
was
conducted
synthesize
literature
on
underlying
processes
cell-derived
small
extracellular
vesicles
(NSC-sEVs)
transplantation
therapy
context
mechanisms
encompass
neuroprotection,
inflammatory
response
suppression,
endogenous
nerve
vascular
regeneration
facilitation.
Nevertheless,
translation
NSC-sEVs
is
hindered
challenges
such
as
inadequate
targeting
efficacy
insufficient
content
loading.
In
light
these
limitations,
we
compiled
advancements
utilizing
modified
treating
stroke
based
methods
vesicle
modification.
conclusion,
examining
NSC-sEVs-based
anticipated
be
both
fundamental
applied
investigations
about
ACS Applied Materials & Interfaces,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 16, 2025
The
involvement
of
neurons
in
the
peripheral
nervous
system
is
crucial
for
bone
regeneration.
Mimicking
extracellular
matrix
cues
provides
a
more
direct
and
effective
strategy
to
regulate
neuronal
activity
enhance
However,
simultaneous
coupling
intrinsic
mechanical-electrical
microenvironment
implants
innervated
regeneration
has
been
largely
neglected.
Inspired
by
mechanical
bioelectric
properties
microenvironment,
this
study
constructed
(M-E)
model
based
on
barium
titanate
piezoelectric
nanoarrays,
which
could
effectively
promote
found
that
provided
nanostructure,
coupled
with
electrical
properties,
created
controllable
M-E.
In
vitro
cell
experiments
demonstrated
activated
Piezo2
VGCC
ion
channels,
promoted
calcium
influx
DRG
neurons,
downstream
PI3K-AKT
RAS
pathways.
This
cascade
events
led
synthesis
release
CGRP
sensory
nerves,
ultimately
enhancing
osteogenic
differentiation
BMSCs.
work
not
only
broadens
current
understanding
biomaterials
mimic
but
also
new
insights
into
Journal of Orthopaedic Surgery and Research,
Год журнала:
2025,
Номер
20(1)
Опубликована: Март 15, 2025
Bone
morphogenetic
protein
9
(BMP9)
and
nerve
growth
factor
(NGF)
are
critical
factors
influencing
osteogenic
differentiation
in
mesenchymal
stem
cells
(MSCs).
While
BMP9
has
been
recognized
for
its
potent
capabilities,
NGF's
role
bone
tissue
engineering
is
less
understood.
This
investigation
delineated
the
synergistic
link
of
with
NGF
driving
C3H10T1/2
MSCs.
To
evaluate
combined
impact
on
markers'
expression
levels
formation
calcified
nodules
cells,
providing
a
basis
enhanced
regeneration
strategies
engineering.
were
subjected
to
treatment
regimens
incorporating
at
variable
concentrations
(10,
50,
100
ng/ml)
BMP9,
either
as
monotherapies
or
combination.
Osteogenic
differentiation'
comprehensive
assessment
was
undertaken
by
quantifying
early-stage
markers
(Runx2,
Col
I)
late-stage
(OPN)
via
RT-PCR,
Western
blotting,
ALP
staining,
Alizarin
Red
S
staining
mineralized
matrix
deposition.
elicited
concentration-dependent
augmentation
early
markers,
10
ng/ml
dosage
demonstrating
maximal
efficacy.
independently
facilitated
robust
differentiation,
whereas
combinatorial
synergistically
amplified
Runx2,
I,
OPN.
Notably,
this
yielded
remarkable
enhancement
deposition
extracellular
matrix,
evidenced
notable
escalation
size
density
relative
monotherapies.
The
findings
unveiled
potentiating
dual-factor
approach
presents
compelling
paradigm
advancing
strategies,
substantial
promise
utilization
plus
regenerative
medicine.
