Advanced technology in neuroscience .,
Год журнала:
2024,
Номер
1(2), С. 244 - 260
Опубликована: Ноя. 27, 2024
Nerve
injury
often
leads
to
degeneration
or
necrosis
of
damaged
nerve
cells,
which
can
result
in
regeneration
disorders
during
the
repair
process.
Promoting
is
a
critical
challenge
treatment
nervous
system
diseases.
With
rapid
advancements
related
research,
chemical
materials
have
shown
significant
promise
facilitating
because
their
excellent
biocompatibility
and
degradability.
The
use
tissue-engineered
material
scaffolds
provide
physical
channels
for
regeneration.
These
create
optimal
conditions
cell
growth
migration
effectively
regulate
physiological
processes
repair.
Therefore,
wide
range
applications
field
This
review
highlights
technological
tools
available
involving
materials.
(1)
Conductive
hydrogels:
Novel
conductive
hydrogels
been
developed
by
integrating
such
as
graphene,
carbon
nanotubes,
polypyrrole,
promote
functional
recovery
cells
through
electrical
stimulation.
(2)
Three-dimensional
printing:
printing
technology
contributes
precise
control
shape,
porosity
degradation
rate
scaffolds,
providing
customized
microenvironment
(3)
Nanomaterials:
unique
physicochemical
properties
nanoparticles
nanofibers
give
them
great
potential
penetrate
blood‒brain
barrier,
guide
targeted
drug
delivery.
(4)
Local
release
bioactive
molecules:
Through
design
materials,
controlled
molecules
factor,
brain-derived
neurotrophic
factor
fibroblast
has
realized,
promotes
(5)
Photothermal
photoacoustic
stimulation:
combination
photothermal
technologies
led
development
capable
responding
photostimulation,
new
avenues
noninvasive
neurostimulation.
engineering
are
highly
effective
promoting
significantly
improve
efficiency
quality
In
clinical
practice,
these
techniques
expected
more
strategies
patients
with
injuries,
improving
function
life.
also
discusses
detail
different
biocompatibility,
mechanical
strength,
degradability,
A
variety
neural
tissue
scaffold
techniques,
including
provision
support,
molecules,
direct
interaction
cells.
Although
show
potential,
several
challenges,
long-term
stability,
individual
variation
response,
large-scale
production,
still
need
be
addressed
before
they
translated
into
applications.
addition,
comprehensive
assessment
safety
efficacy
focus
future
research.
Future
research
will
on
optimizing
conducting
trials
validate
techniques.
The
repair
of
articular
cartilage
defects
remains
a
major
regenerative
and
clinical
challenge.
Exosomes
(Exos)
derived
from
mesenchymal
stem
cells
(MSCs)
have
good
application
potential
in
tissue
engineering.
Numerous
studies
indicated
that
appropriate
preconditioning
methods
can
promote
the
therapeutic
effect
Exos.
Growth
differentiation
factor
5
(GDF-5)
plays
critical
role
chondrogenesis
regeneration.
In
this
study,
GDF-5
was
used
to
precondition
synovial
(SMSCs)
increase
chondrogenic-promoting
Exos
(G-Exos).
addition,
we
demonstrated
G-Exos
rich
miR-383-3p
increased
chondrogenic
SMSCs
by
activating
Kdm2a/SOX2
signaling
pathway.
On
basis,
were
loaded
into
glycyrrhizic
acid/methacrylate-acylated
hyaluronic
acid
(GA/HA/G-Exos)
scaffold
via
digital
light
processing
(DLP)
bioprinting
maintain
bioactivity
sustained
release.
GA/HA/G-Exos
scaffolds
not
only
presented
significant
biological
properties
vitro
but
also
significantly
promoted
remodeling
joint
cavity
microenvironment
regeneration
Sprague-Dawley
rats.
This
study
provides
promising
cell-free
strategy
for
defect
use
engineered
exofunctionalized
scaffolds.
Journal of Materials Chemistry B,
Год журнала:
2024,
Номер
12(37), С. 9375 - 9389
Опубликована: Янв. 1, 2024
The
3D
printed
scaffolds
constructed
from
polymers
have
shown
significant
potential
in
the
field
of
bone
defect
regeneration.
However,
efficacy
these
can
be
markedly
reduced
certain
pathological
conditions
like
diabetes,
where
an
altered
inflammatory
microenvironment
and
diminished
small
blood
vessels
complicate
integration
with
host
tissue.
In
this
study,
bioactivity
a
3D-printed
poly(lactide-
Materials Advances,
Год журнала:
2024,
Номер
5(22), С. 8927 - 8936
Опубликована: Янв. 1, 2024
In
this
study,
Ast-contained
CS
scaffolds
have
great
potential
for
bone
regeneration
and
an
innovative
approach
combines
advanced
biomaterials
technology
with
existing
treatment
methods
to
maximize
benefits.
Advanced technology in neuroscience .,
Год журнала:
2024,
Номер
1(2), С. 244 - 260
Опубликована: Ноя. 27, 2024
Nerve
injury
often
leads
to
degeneration
or
necrosis
of
damaged
nerve
cells,
which
can
result
in
regeneration
disorders
during
the
repair
process.
Promoting
is
a
critical
challenge
treatment
nervous
system
diseases.
With
rapid
advancements
related
research,
chemical
materials
have
shown
significant
promise
facilitating
because
their
excellent
biocompatibility
and
degradability.
The
use
tissue-engineered
material
scaffolds
provide
physical
channels
for
regeneration.
These
create
optimal
conditions
cell
growth
migration
effectively
regulate
physiological
processes
repair.
Therefore,
wide
range
applications
field
This
review
highlights
technological
tools
available
involving
materials.
(1)
Conductive
hydrogels:
Novel
conductive
hydrogels
been
developed
by
integrating
such
as
graphene,
carbon
nanotubes,
polypyrrole,
promote
functional
recovery
cells
through
electrical
stimulation.
(2)
Three-dimensional
printing:
printing
technology
contributes
precise
control
shape,
porosity
degradation
rate
scaffolds,
providing
customized
microenvironment
(3)
Nanomaterials:
unique
physicochemical
properties
nanoparticles
nanofibers
give
them
great
potential
penetrate
blood‒brain
barrier,
guide
targeted
drug
delivery.
(4)
Local
release
bioactive
molecules:
Through
design
materials,
controlled
molecules
factor,
brain-derived
neurotrophic
factor
fibroblast
has
realized,
promotes
(5)
Photothermal
photoacoustic
stimulation:
combination
photothermal
technologies
led
development
capable
responding
photostimulation,
new
avenues
noninvasive
neurostimulation.
engineering
are
highly
effective
promoting
significantly
improve
efficiency
quality
In
clinical
practice,
these
techniques
expected
more
strategies
patients
with
injuries,
improving
function
life.
also
discusses
detail
different
biocompatibility,
mechanical
strength,
degradability,
A
variety
neural
tissue
scaffold
techniques,
including
provision
support,
molecules,
direct
interaction
cells.
Although
show
potential,
several
challenges,
long-term
stability,
individual
variation
response,
large-scale
production,
still
need
be
addressed
before
they
translated
into
applications.
addition,
comprehensive
assessment
safety
efficacy
focus
future
research.
Future
research
will
on
optimizing
conducting
trials
validate
techniques.
