DNAzyme-Assisted the Detection of rps27l mRNA in Protein Nanopores
Analytica Chimica Acta,
Год журнала:
2025,
Номер
unknown, С. 343711 - 343711
Опубликована: Янв. 1, 2025
Язык: Английский
Highly Sensitive and Interference-Free Detection of Multiple Drug Molecules in Serum Using Dual-Modified SERS Substrates Combined with AI Algorithm Analysis
Analytical Chemistry,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 3, 2025
Surface-enhanced
Raman
spectroscopy
(SERS)
technology
has
shown
broad
potential
in
drug
concentration
detection,
but
its
application
blood
monitoring
faces
significant
challenges.
The
primary
difficulty
lies
overcoming
the
interference
caused
by
various
biomolecules
present
serum,
which
can
severely
obscure
SERS
signals
of
target
molecules.
Traditional
enhancement
substrates
are
often
limited
to
detecting
single
drugs
and
prone
interference,
making
label-free
detection
multiple
particularly
challenging.
To
address
these
issues,
we
developed
a
novel
substrate
based
on
Au@AgNRs,
undergoes
two-step
modification
produce
Au@AgDBCNRs.
This
innovative
provides
exceptional
signal
amplification,
simultaneously
allowing
sensitive
Moreover,
our
method
eliminates
need
for
serum
deproteinization,
enabling
direct
while
effectively
mitigating
from
components.
cetyltrimethylammonium
bromide
coating
Au@AgDBCNRs
is
an
internal
standard
quantification
without
additional
standards.
platform
significantly
improves
accuracy
efficiency
automatically
integrating
artificial
intelligence
recognize
analyze
spectral
features.
new
idea
therapeutic
expected
provide
rapid,
accurate,
cost-effective
clinical
environment,
great
improving
patient
care
optimizing
dosage
strategies.
Язык: Английский
Pore lipid modifications modulate MscS nanopore for enhanced single-molecule sensing
Biosensors and Bioelectronics,
Год журнала:
2025,
Номер
276, С. 117250 - 117250
Опубликована: Фев. 11, 2025
Язык: Английский
Nanopore Environmental Analysis
JACS Au,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 1, 2025
Язык: Английский
Beta-Barrel Nanopores as Diagnostic Sensors: An Engineering Perspective
Biosensors,
Год журнала:
2024,
Номер
14(7), С. 345 - 345
Опубликована: Июль 16, 2024
Biological
nanopores
are
ultrasensitive
and
highly
attractive
platforms
for
disease
diagnostics,
including
the
sequencing
of
viral
microbial
genes
detection
biomarkers
pathogens.
To
utilize
biological
as
diagnostic
sensors,
they
have
been
engineered
through
various
methods
resulting
in
accurate
sensitive
disease-related
biomolecules.
Among
diverse
nanopores,
β-barrel-containing
advantages
nanopore
engineering
because
their
robust
structure,
making
them
well-suited
modifications.
In
this
review,
we
highlight
approaches
used
single-molecule
sensing
applications
early
diagnosis
prognosis.
highlighted
studies,
β-barrel
can
be
modified
by
genetic
mutation
to
change
structure;
alter
charge
distributions;
or
add
enzymes,
aptamers,
protein
probes
enhance
sensitivity
accuracy.
Furthermore,
review
discusses
challenges
future
perspectives
advancing
nanopore-based
sensors.
Язык: Английский