Chemical materials involved in neural tissue engineering scaffold techniques: a narrative review DOI

Miao Li,

Jinhui Zhou,

Yuxiang Ning

и другие.

Advanced technology in neuroscience ., Год журнала: 2024, Номер 1(2), С. 244 - 260

Опубликована: Ноя. 27, 2024

Nerve injury often leads to degeneration or necrosis of damaged nerve cells, which can result in regeneration disorders during the repair process. Promoting is a critical challenge treatment nervous system diseases. With rapid advancements related research, chemical materials have shown significant promise facilitating because their excellent biocompatibility and degradability. The use tissue-engineered material scaffolds provide physical channels for regeneration. These create optimal conditions cell growth migration effectively regulate physiological processes repair. Therefore, wide range applications field This review highlights technological tools available involving materials. (1) Conductive hydrogels: Novel conductive hydrogels been developed by integrating such as graphene, carbon nanotubes, polypyrrole, promote functional recovery cells through electrical stimulation. (2) Three-dimensional printing: printing technology contributes precise control shape, porosity degradation rate scaffolds, providing customized microenvironment (3) Nanomaterials: unique physicochemical properties nanoparticles nanofibers give them great potential penetrate blood‒brain barrier, guide targeted drug delivery. (4) Local release bioactive molecules: Through design materials, controlled molecules factor, brain-derived neurotrophic factor fibroblast has realized, promotes (5) Photothermal photoacoustic stimulation: combination photothermal technologies led development capable responding photostimulation, new avenues noninvasive neurostimulation. engineering are highly effective promoting significantly improve efficiency quality In clinical practice, these techniques expected more strategies patients with injuries, improving function life. also discusses detail different biocompatibility, mechanical strength, degradability, A variety neural tissue scaffold techniques, including provision support, molecules, direct interaction cells. Although show potential, several challenges, long-term stability, individual variation response, large-scale production, still need be addressed before they translated into applications. addition, comprehensive assessment safety efficacy focus future research. Future research will on optimizing conducting trials validate techniques.

Язык: Английский

From Mechanoelectric Conversion to Tissue Regeneration: Translational Progress in Piezoelectric Materials DOI Creative Commons
Xinyu Wang, Sílvio Terra Stefanello,

Victor Shahin

и другие.

Advanced Materials, Год журнала: 2025, Номер unknown

Опубликована: Май 28, 2025

Abstract Piezoelectric materials, capable of converting mechanical stimuli into electrical signals, have emerged as promising tools in regenerative medicine due to their potential stimulate tissue repair. Despite a surge research on piezoelectric biomaterials, systematic insights direct translational optimization remain limited. This review addresses the current landscape by bridging fundamental principles with clinical potential. The biomimetic basis piezoelectricity, key molecular pathways involved synergy between and stimulation for enhanced regeneration, critical considerations material optimization, structural design, biosafety is discussed. More importantly, status quagmire mechanisms applications recent years are explored. A mechanism‐driven strategy proposed therapeutic application biomaterials repair identify future directions accelerated applications.

Язык: Английский

Процитировано

0
Accelerating Wound Healing through a Mechano-Electric Synergistic Conductive Hydrogel DOI
Yingying Nie,

Cewen Hu,

Xinyue Huang

и другие.

ACS Applied Bio Materials, Год журнала: 2025, Номер unknown

Опубликована: Май 27, 2025

To address the challenge of achieving faster wound healing, we present an innovative approach using hydrogel dressings that leverage mechano-electric synergistic effect. This method incorporates piezoelectric zinc oxide nanoparticles (ZnO NPs) and conductive carbon nanotubes (CNTs) into a thermosensitive poly(N-isopropylacrylamide) (PNIPAM) matrix. The engineered demonstrates exceptional mechanical strength, optimal swelling properties, enhanced antibacterial activity, excellent biocompatibility biosafety. Upon application to site, undergoes temperature-induced centripetal contraction, which enhances closure process. Moreover, morphological changes in caused by self-contraction alterations skin shape can trigger effect, generating stable lasting bioelectric signals promote fibroblast migration. Consequently, approximately 1 cm2 size nearly completely heal within 14 days, thanks hydrogel's multifaceted therapeutic potential, including anti-inflammatory effects, promotion cell migration, induction fibroblast-to-myofibroblast differentiation, enhancement angiogenesis. breakthrough represents significant advancement over conventional dressings, offering considerable promise for clinical application.

Язык: Английский

Процитировано

0
Pagoda-Shaped Adhesive Microneedles Loaded with Ketorolac for Aortic Dissection Treatment DOI

Mengxiao Shi,

Rui Liu, Hong Fang

и другие.

ACS Applied Materials & Interfaces, Год журнала: 2025, Номер unknown

Опубликована: Май 30, 2025

Aortic dissection is a serious health risk and has led to interest in creating effective drug treatments like ketorolac. However, conventional administration techniques lack specificity, which limits their effectiveness may result adverse effects. A microneedle patch system (MNPS) offers minimally invasive, pain-free alternative with high capacity for delivery, but there still gap the direction of treating aortic dissection. Here, we present novel biodegradable MNPS pagoda-shaped structure designed loading. These were fabricated using stepwise mold replication method, medication embedded top layer MNPS. The double-layered pagoda enhances adhesion, enabling it withstand impact blood flow enhancing targeting. In conclusion, our introduces new approach dissection, providing hope affected patients.

Язык: Английский

Процитировано

0
An injectable thermosensitive pluronic F127 loaded-nanohydroxyapatite / Polydopamine for promoting sciatic nerve repair after crush injury DOI

Liping Kang,

Eugene Fang,

Muge Gu

и другие.

Colloids and Surfaces B Biointerfaces, Год журнала: 2024, Номер 245, С. 114324 - 114324

Опубликована: Окт. 17, 2024

Язык: Английский

Процитировано

1
Chemical materials involved in neural tissue engineering scaffold techniques: a narrative review DOI

Miao Li,

Jinhui Zhou,

Yuxiang Ning

и другие.

Advanced technology in neuroscience ., Год журнала: 2024, Номер 1(2), С. 244 - 260

Опубликована: Ноя. 27, 2024

Nerve injury often leads to degeneration or necrosis of damaged nerve cells, which can result in regeneration disorders during the repair process. Promoting is a critical challenge treatment nervous system diseases. With rapid advancements related research, chemical materials have shown significant promise facilitating because their excellent biocompatibility and degradability. The use tissue-engineered material scaffolds provide physical channels for regeneration. These create optimal conditions cell growth migration effectively regulate physiological processes repair. Therefore, wide range applications field This review highlights technological tools available involving materials. (1) Conductive hydrogels: Novel conductive hydrogels been developed by integrating such as graphene, carbon nanotubes, polypyrrole, promote functional recovery cells through electrical stimulation. (2) Three-dimensional printing: printing technology contributes precise control shape, porosity degradation rate scaffolds, providing customized microenvironment (3) Nanomaterials: unique physicochemical properties nanoparticles nanofibers give them great potential penetrate blood‒brain barrier, guide targeted drug delivery. (4) Local release bioactive molecules: Through design materials, controlled molecules factor, brain-derived neurotrophic factor fibroblast has realized, promotes (5) Photothermal photoacoustic stimulation: combination photothermal technologies led development capable responding photostimulation, new avenues noninvasive neurostimulation. engineering are highly effective promoting significantly improve efficiency quality In clinical practice, these techniques expected more strategies patients with injuries, improving function life. also discusses detail different biocompatibility, mechanical strength, degradability, A variety neural tissue scaffold techniques, including provision support, molecules, direct interaction cells. Although show potential, several challenges, long-term stability, individual variation response, large-scale production, still need be addressed before they translated into applications. addition, comprehensive assessment safety efficacy focus future research. Future research will on optimizing conducting trials validate techniques.

Язык: Английский

Процитировано

1