IL-15 functionalized biomimetic hybrid mRNA vaccine for enhanced NSCLC immunotherapy via synergistic activation of T cells and NK cells DOI Creative Commons

Jueshuo Guo,

Peng Li, Pei Ma

и другие.

Materials Today Bio, Год журнала: 2025, Номер unknown, С. 101914 - 101914

Опубликована: Май 1, 2025

Язык: Английский

Nanoparticles Modulating the Immune Microenvironment in Breast Cancer Treatment DOI Creative Commons
Lijuan Guo, Jinsheng Wu,

Weifeng Lu

и другие.

International Journal of Nanomedicine, Год журнала: 2025, Номер Volume 20, С. 1367 - 1382

Опубликована: Фев. 1, 2025

Abstract: Breast cancer remains a significant therapeutic challenge, with the immune microenvironment playing crucial role in its progression and treatment response. This review investigates potential of nanoparticles to modulate breast therapy. Initially, we discuss composition influence on cancer, followed by current strategies targeting these components. We then provide for cells such as macrophages, dendritic cells, T-cells. The enhancing checkpoint blockade (ICB) their application vaccines is also examined. Additionally, explore synergistic effects combining conventional therapies. addresses challenges clinical translation, focusing safety, biocompatibility, toxicity. Finally, outline future research directions advancements nanoparticle-based immunotherapy, emphasizing transformative impact treatment. Keywords: nanoparticle,

Язык: Английский

Процитировано

0
A dual-warhead high-density lipoprotein mimetic nanomedicine simultaneously regulates stromal extracellular matrix and cGAS/STING activation for potent immunotherapy of cancer DOI
Weiwei Wu,

Gao Xiaoyang,

Haina Tian

и другие.

Nano Today, Год журнала: 2025, Номер 61, С. 102656 - 102656

Опубликована: Фев. 5, 2025

Язык: Английский

Процитировано

0
Genetically Engineered Magnesium/Manganese Nanoparticles for Cancer Radioimmunotherapy DOI

Jicheng Wu,

Yangtao Xu, Yunjing Zhang

и другие.

Опубликована: Янв. 1, 2025

Язык: Английский

Процитировано

0
Mitoxantrone‐Encapsulated ZIF‐8 Enhances Chemo‐Immunotherapy via Amplified Immunogenic Cell Death DOI Creative Commons
Junhong Li,

Wenxing Lv,

Ziwei Han

и другие.

Advanced Science, Год журнала: 2025, Номер unknown

Опубликована: Фев. 14, 2025

Abstract Chemo‐immunotherapy, combining systemic chemotherapeutic drugs and immune checkpoint blockers, is a promising paradigm in cancer treatment. However, challenges such as limited induction of responses toxicity have hindered its clinical applications. Here, zeolite imidazolate framework‐8 (ZIF‐8) that encapsulates mitoxantrone (MIT), an cell death (ICD)‐inducing agent (MIT@ZIF‐8), synthesized using one‐pot aqueous‐phase process. ZIF‐8 serves dual‐functional nanomaterial for chemo‐immunotherapy: carrier to enhance tumor uptake MIT improved chemotherapy efficacy, pyroptosis inducer amplify MIT‐induced ICD augmented anti‐tumor responses. As result, vivo administration MIT@ZIF‐8 markedly inhibits growth both immunologically “hot” colon “cold” prostate cancer. Moreover, treatment increases the abundance cytotoxic CD8 + T cells reduces amount immunosuppressive regulatory tumors, thereby enhancing immunity sensitizing anti‐CTLA‐4 immunotherapy. In summary, offers highly translational approach chemo‐immunotherapy.

Язык: Английский

Процитировано

0
Biomimetic Nanoparticles for Targeted Lung Cancer Immunotherapy via Specific Clearance of High Potassium DOI Creative Commons

Jiaqi You,

Jie Shen, Wenwen Liu

и другие.

ACS Applied Nano Materials, Год журнала: 2025, Номер unknown

Опубликована: Фев. 18, 2025

Язык: Английский

Процитировано

0
Nanozyme-Based Strategies in Cancer Immunotherapy: Overcoming Resistance to Enhance Therapeutic Efficacy DOI Creative Commons
Guangjian Hou, Yukun Xu, Chunhua Wang

и другие.

Aging and Disease, Год журнала: 2025, Номер unknown, С. 0 - 0

Опубликована: Янв. 1, 2025

Nanozymes, which are nanomaterials that replicate the catalytic activities of natural enzymes in biological systems, have recently demonstrated considerable potential improving cancer immunotherapy by altering tumor microenvironment. Nanozyme-driven immune responses represent an innovative therapeutic modality with high effectiveness and minimal side effects. These nanozymes activate system to specifically recognize destroy cells. Combined immunotherapeutic agents, can amplify anti-cancer integrating remodeling immunogenic cell death (ICD). This review offers a thorough discussion about various involved immunity, including those mimicking catalase (CAT), superoxide dismutase (SOD), peroxidase (POD), oxidase (OXD). It also discusses challenges future directions for translating nanozyme platforms into clinical applications, enhancing susceptibility cells immunotherapy. Nanozyme-based strategies substantial oncology, offering new effective options management.

Язык: Английский

Процитировано

0
Progress of extracellular vesicles-based system for tumor therapy DOI
Fei Wang,

Le Yin,

Yong Hu

и другие.

Journal of Controlled Release, Год журнала: 2025, Номер unknown

Опубликована: Фев. 1, 2025

Язык: Английский

Процитировано

0
Antiviral covalent ACE2 vesicle spray DOI Creative Commons
Qian‐Fang Meng, Yu Han, Yu Liu

и другие.

Опубликована: Март 1, 2025

Процитировано

0
Recent progress of advanced Nanozymes for targeted oncotherapy and synergistic immunotherapy DOI

Wenying Zhang,

Meifang Wang,

Ping’an Ma

и другие.

Coordination Chemistry Reviews, Год журнала: 2025, Номер 536, С. 216674 - 216674

Опубликована: Апрель 5, 2025

Язык: Английский

Процитировано

0
Recent advances in biomimetic nanodelivery systems for cancer Immunotherapy DOI Creative Commons
Jiawei Yang, Xueqi Li, Tongyu Li

и другие.

Materials Today Bio, Год журнала: 2025, Номер unknown, С. 101726 - 101726

Опубликована: Апрель 1, 2025

Язык: Английский

Процитировано

0