Soft Matter, Год журнала: 2024, Номер unknown
Опубликована: Ноя. 29, 2024
Numerical simulations predict that the interplay between active motion and microstructure advection leads to enhanced rotational diffusion spontaneous rotation of Janus colloids in complex fluids.
Язык: Английский
International Journal of Pharmaceutics, Год журнала: 2025, Номер 670, С. 125201 - 125201
Опубликована: Янв. 10, 2025
Язык: Английский
Процитировано
0
ACS Nano, Год журнала: 2025, Номер unknown
Опубликована: Фев. 25, 2025
Over the past two decades, nanotechnology has made significant progress toward development and applications of micromotors (MMs) nanomotors (NMs). Characterized by their capability to self-propel swim in fluids, they have emerged as promising tools various fields, particularly biomedicine. This Review presents an overview current state MMs NMs, motion viscous media complex environments, interaction with biological barriers, potential therapeutical applications. We identify choice appropriate administration routes reach target location a key aspect success NMs biomedical Looking ahead, we envision playing role treating diverse medical disorders, recent proof-of-concept vivo studies demonstrate distinct capabilities versatility. However, addressing regulatory, scalability, biocompatibility, safety concerns remains imperative for successful translation into clinical trials industrial-scale production. work provides guideline researchers, guiding them through landscape, challenges, prospects using biomedicine, thereby encouraging responsible positioning future nanomedicine. Furthermore, outline critical areas further research, including on safety, methods overcome physical obstacles.
Язык: Английский
Процитировано
0
ACS Nano, Год журнала: 2025, Номер unknown
Опубликована: Март 19, 2025
Excessive reactive oxygen species, disruption of the epithelial barrier, immune dysregulation, and gut microbiota imbalance are key factors driving onset inflammatory bowel disease (IBD) complicating its treatment. Prompt diagnosis diseases precise delivery therapeutic agents to inflamed intestinal sites offer promising targeted strategies for effectively treating IBD. Here, a barium sulfate-based nanoplatform (BaSO4@PDA@CeO2/DSP, BPCD) synergistic nanozymes drugs was developed. With enhanced colonic retention after oral drug delivery, this enables effective targeting CT imaging guidance address multiple contributing A comprehensive effect achieved through action cerium oxide with optimized Ce3+/Ce4+ ratio sustained release dexamethasone sodium phosphate. Benefiting from superior gastrointestinal stability, is highly in IBD by alleviating oxidative stress, modulating macrophage polarization balance, flora composition, repairing barrier. BPCD inhibits development mechanisms has biocompatibility, emerging as practical alternative traditional therapies.
Язык: Английский
Процитировано
0
Advanced Functional Materials, Год журнала: 2025, Номер unknown
Опубликована: Март 30, 2025
Abstract Acinetobacter baumannii ( A. ) is a leading cause of pneumonia. Conventional antibiotics can increase the risk drug resistance and non‐specifically harm microflora, disrupting their balance. In addition to pathogenic bacteria, lung inflammation also damages tissue. This study develops an aptamer/polymer‐functionalized mesoporous polydopamine/silver nanocomposite (Apt/ODEA‐PDA/Ag‐ICG) specifically target sequentially exhibit antibacterial/antioxidative properties for pneumonia treatment. After synthesizing polyzwitterion (ODEA), polymer/aptamer conjugated with PDA/Ag core, ICG further labeled fabricate nanocomposite. Upon intratracheal instillation, nanocomposites penetrate mucus barrier help polyzwitterions. The precisely targets through specific recognition by aptamer, without affecting other microflora. Moreover, distributed disorderedly within polymer. near core contributes high NIR‐I absorbance good photothermal ability. from acts as fluorescent molecule imaging. Furthermore, efficiently exhibits synergistic antibacterial activity owing acidic environment/heat‐accelerated Ag + release effect. Importantly, alongside release, antioxidant ability PDA scavenges reactive oxygen species alleviates inflammation, thereby accelerating summary, provide alternative approach designing advanced systems.
Язык: Английский
Процитировано
0
Nano Biomedicine and Engineering, Год журнала: 2024, Номер unknown
Опубликована: Сен. 1, 2024
Язык: Английский
Процитировано
2
European Journal of Pharmaceutics and Biopharmaceutics, Год журнала: 2024, Номер 205, С. 114574 - 114574
Опубликована: Ноя. 7, 2024
Язык: Английский
Процитировано
2
Nature Communications, Год журнала: 2024, Номер 15(1)
Опубликована: Окт. 29, 2024
Enzymatic nanomotors harvest kinetic energy through the catalysis of chemical fuels. When a drop containing is placed in fuel-rich environment, they assemble into ordered groups and exhibit intriguing collective behaviour akin to bioconvection aerobic microorganismal suspensions. This presents numerous advantages compared individual nanomotors, including expanded coverage prolonged propulsion duration. However, physical mechanisms underlying motion have yet be fully elucidated. Our study investigates formation enzymatic swarms using experimental analysis computational modelling. We show that directional movement nanomotor due their solutal buoyancy. investigate various factors impact swarms, such as particle concentration, fuel viscosity, vertical confinement. examine effects these on swarm self-organization gain deeper understanding. In addition, urease reaction produces ammonia carbon dioxide, accelerating active urea with passive ones same conditions. The numerical agrees findings. findings are crucial for potential biomedical applications ranging from enhanced diffusion bio-fluids targeted delivery cancer therapy.
Язык: Английский
Процитировано
1
Journal of Nanobiotechnology, Год журнала: 2024, Номер 22(1)
Опубликована: Ноя. 1, 2024
Orally administered nanocarriers play an important role in improving druggability, promoting intestinal absorption, and enhancing therapeutic applications for the treatment of local systemic diseases. However, delivering efficiency cell response mucosa to orally is affected by physiological environment barriers gastrointestinal tract, physicochemical properties nanocarriers, their bidirectional interactions. Goblet cells secrete form extracellular mucus, which hinders movement nanoparticles. Meanwhile, epithelial may absorb NPs, allowing transcytosis or degradation. Conversely, nanoparticle-induced toxicity occur as a biological nanoparticle exposure. Additionally, immune functions secretions such mucin, peptide, cytokines also be altered. In this review, we discuss interactions between nanoparticles focusing on enterocytes goblet cells, M according essential crosstalk with cells. Furthermore, recent advances how physiochemical influence interplay, delivery, fate mucosa. Understanding different from perspective interaction provides support development, rational design, potency maximation, application advanced oral nanocarrier delivery systems.
Язык: Английский
Процитировано
1
Advanced Healthcare Materials, Год журнала: 2024, Номер unknown
Опубликована: Окт. 8, 2024
Tumor microenvironment, characterized by dense extracellular matrix and severe hypoxia, has caused pronounced resistance to photodynamic therapy (PDT). Herein, it designed an artificial nitric oxide (NO) nanotractor with a unique "motor-cargo" structure, where photoswitching upconversion nanoparticle (UCNP) core serves as the optical engine harvest NIR light asymmetrically coated mesoporous silica (SiO
Язык: Английский
Процитировано
0
Soft Matter, Год журнала: 2024, Номер unknown
Опубликована: Ноя. 29, 2024
Numerical simulations predict that the interplay between active motion and microstructure advection leads to enhanced rotational diffusion spontaneous rotation of Janus colloids in complex fluids.
Язык: Английский
Процитировано
0