Bioactive Materials, Год журнала: 2024, Номер 46, С. 213 - 228
Опубликована: Дек. 16, 2024
Язык: Английский
ACS Biomaterials Science & Engineering, Год журнала: 2025, Номер unknown
Опубликована: Янв. 23, 2025
Oral ulcer wounds are difficult to heal due bacterial infections, persistent inflammatory responses, and excessive reactive oxygen species (ROS). Therefore, the elimination of bacteria, removal ROS, reduction inflammation prerequisites for treatment mouth wounds. In this study, oligomeric proanthocyanidins (OPC) 3-(aminomethyl)phenylboronic acid-modified hyaluronic acid (HP) were used form polymer gels through dynamic covalent borate bonds. Minocycline hydrochloride (MH) was then loaded into gel, a multifunctional MH/OPC-HP microneedles (MNs) with ROS-responsive properties prepared using vacuum method. The MNs can rapidly release MH in diffusive manner sustainably OPC response ROS. gel-based extended retention oral ulcers, leading prolonged ROS scavenging effects. Cytocompatibility hemocompatibility tests showed that had good biocompatibility. Antibacterial experiments demonstrated exhibited excellent antibacterial vitro indicated could effectively clear reduce oxidative stress damage, inhibit M1-type macrophage polarization, induce M2-type polarization. Furthermore, vivo revealed pro-inflammatory cytokines, promote neovascularization, accelerate epithelial healing significantly rat model wound infection. summary, hold promise as therapeutic strategy enhancing
Язык: Английский
Процитировано
1
ACS Nano, Год журнала: 2025, Номер unknown
Опубликована: Март 24, 2025
N-type calcium channel (CaV2.2) protein contributes to neuronal excitability and overactivation in sympathetic ganglion (SG) following myocardial infarction (MI), thereby easily triggering cardiac remodeling ventricular arrhythmias (VAs). Despite much advances the understanding of CaV2.2, a neuron-targeted modifying treatment is, yet, infrequently realized. Moreover, establishing specific delivery strategy stable probe architecture with an extensive molecular structure pursuit complex CaV2.2 regulation still remains challenge. Herein, we develop smart DNA nanoflower (sDNF) composite by utilizing customizable design scalable production from multifunctionality-encoded template that self-assembles into biomimetic nanoarchitecture. The nanoarchitecture contains neuron-targeting aptamer decorated mediator peptide-DNA bioconjugate. combined targeted release peptide synergistically led ∼31% reduction peak current neuron cells. sDNF alleviated MI-induced SG hyperactivity improved vivo outcomes, such as decreasing susceptibility VAs relieving neuropathic pain for 10 h. infarct size treated is reduced approximately 11.1%. It envisioned DNF-based nanostructure suppression inhibition along relief provides potential approach clinical sympathetic-associated cardiovascular diseases.
Язык: Английский
Процитировано
1
Frontiers in Bioengineering and Biotechnology, Год журнала: 2025, Номер 12
Опубликована: Янв. 10, 2025
Bacterial infection, a complex wound microenvironment, and persistent inflammatory response in acute wounds can result delayed healing abnormal scar formation, thereby compromising the normal function aesthetic appearance of skin tissue. This issue represents one most challenging problems clinical practice. study aims to develop hydrogel dressing specifically designed for treatment wounds, providing immediate effective protection affected areas. innovation seeks offer novel advanced solution management wounds. In this study, composite scaffold was synthesized through reaction between oxidized glycyrrhizic acid carboxymethyl chitosan Schiff base. The material properties were systematically characterized, its biocompatibility antibacterial efficacy rigorously evaluated. A rat model established compare multiple groups, assessing impact on microenvironment repair. results demonstrated that OGA-CMCS exhibited excellent injectability, biocompatibility, properties. It capable enhancing which turn influenced polarization macrophages from M1 M2 phenotype, mitigating response, promoting angiogenesis granulation tissue regeneration, accelerating healing. successfully developed glycyrrhizin-based dressing, not only introduces innovative approaches emergency surface defects but also provides an experimental foundation. is anticipated contribute significantly addressing relevant challenges.
Язык: Английский
Процитировано
0
ACS Biomaterials Science & Engineering, Год журнала: 2025, Номер unknown
Опубликована: Апрель 1, 2025
Hydrogel wound dressings have emerged as a promising solution for healing due to their excellent mechanical and biochemical properties. Over recent years, there has been significant progress in expanding the variety of raw materials used hydrogel formulation along with development advanced modification techniques design approaches that enhance performance. However, comprehensive review encompassing diverse polymer strategies innovations is still lacking literature. This summarizes use natural polymers (e.g., chitosan, gelatin, sodium alginate, hyaluronic acid, dextran) synthetic poly(vinyl alcohol), polyethylene glycol, Pluronic F-127, poly(N-isopropylacrylamide), polyacrylamide, polypeptides) dressings. We further explore advantages limitations these discuss various strategies, including cationic modification, oxidative double-bond catechol etc. The also addresses principles synthesis methods, aligning modifications specific requirements healing. Finally, we future challenges opportunities hydrogel-based
Язык: Английский
Процитировано
0
Journal of Bioresources and Bioproducts, Год журнала: 2024, Номер unknown
Опубликована: Дек. 1, 2024
Язык: Английский
Процитировано
1
Journal of Colloid and Interface Science, Год журнала: 2024, Номер 683, С. 752 - 772
Опубликована: Дек. 17, 2024
Язык: Английский
Процитировано
1
International Journal of Biological Macromolecules, Год журнала: 2024, Номер 285, С. 138349 - 138349
Опубликована: Дек. 4, 2024
Язык: Английский
Процитировано
0
Опубликована: Янв. 1, 2024
Язык: Английский
Процитировано
0
Bioactive Materials, Год журнала: 2024, Номер 46, С. 213 - 228
Опубликована: Дек. 16, 2024
Язык: Английский
Процитировано
0