Advanced Healthcare Materials,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 9, 2025
Fungal
infections
pose
a
significant
global
public
health
threat,
particularly
candidemia
and
biofilm
formation.
Current
antifungal
drugs
have
limitations
due
to
their
toxicity
drug
resistance.
Ion
interference
therapy,
cuproptosis,
shows
potential
for
disease
treatment.
Herein,
nano
copper-chelate
Cu(DDC)2@BSA
(CDB)
is
synthesized
research
the
mechanism
of
cuproptosis-like
death
investigated.
Initially,
CDB
demonstrates
strong
inhibitory
effect
on
multiple
fungi
exhibits
activity
against
two
fluconazole-resistant
clinical
isolates.
The
decrease
in
ATPase
mitochondrial
membrane
indicates
that
may
involve
dysfunction.
Subsequently,
transcriptome
analysis
reveals
alterations
genes
related
copper
ions
transport
regulation,
oxidative
phosphorylation,
function.
Additionally,
overload
observed,
along
with
an
increase
heat
shock
protein
70
levels
lipoic
acid
synthetase
expression.
Given
biofilms
hinder
penetration,
quaternary
ammonium
chitosan
microneedles
are
employed
combination
penetrate
barrier
enhance
effect.
Overall,
this
study
provides
new
insight
into
presents
promising
strategy
fungal
infection
treatment
through
microneedle
delivery
system.
ACS Nano,
Год журнала:
2024,
Номер
18(46), С. 31923 - 31940
Опубликована: Ноя. 7, 2024
Bacterial
pneumonia
is
one
of
the
most
challenging
global
infectious
diseases
with
high
morbidity
and
mortality.
Considering
antibiotic
abuse
resistance
bacterial
biofilms,
a
variety
metal-based
materials
have
been
developed.
However,
due
to
oxygen
environment
lungs,
some
aerobic
infection
bacteria
tolerance
ROS,
based
on
ROS
may
not
achieve
good
therapeutic
effects.
Inspired
by
sensitivity
cuproptosis
respiratory
cells,
we
designed
copper
composite
antibacterial
nanoparticle
found
that
it
can
effectively
induce
cuproptosis-like
death
in
lungs.
To
address
challenge
Journal of Nanobiotechnology,
Год журнала:
2024,
Номер
22(1)
Опубликована: Ноя. 15, 2024
Bacterial
infections,
especially
induced
by
multidrug-resistant
pathogens,
have
become
a
significant
global
health
concern.
In
the
infected
tissues,
biofilms
not
only
serve
as
source
of
nutrients
but
also
act
protective
barriers
that
impede
antibiotic
penetration.
Herein,
we
developed
tea
polyphenols
epigallocatechin
gallate
(EGCG)
Au
nanoparticles
(E-Au
NPs)
through
direct
one-step
self-assembly
methods
EGCG
chelating
with
ions
to
eradicate
antibiotic-resistant
bacteria
methicillin-resistant
Staphylococcus
aureus
(MRSA)
and
prevent
formation
biofilm
under
near-infrared
(NIR)
irradiation.
The
outstanding
antibacterial
effect
involved
in
mild
photothermal
therapy,
reactive
oxygen
species
production,
pathogenicity-related
genes
regulation,
quinoprotein
were
specific
polyphenol-based
NPs.
excellent
anti-inflammatory
therapeutic
efficacy
E-Au
NPs
was
validated
topically
applied
murine
MRSA-infected
skin
wounds
keratitis
model
vivo
kill
bacteria,
reduce
inflammation
response
promote
wound
healing.
Furthermore,
ophthalmic
systemic
biosafety
profiles
thoroughly
evaluated
while
no
side
effects
revealed
achieving
balance
between
high-efficiency
properties
biocompatibility.
This
study
provides
an
effective
agent
metal-phenolic
materials
for
superficial
tissue
infection
favorable
prognosis
potential
clinical
translation.
Advanced Healthcare Materials,
Год журнала:
2024,
Номер
unknown
Опубликована: Окт. 10, 2024
The
World
Health
Organization
has
warned
that
without
effective
action,
deaths
from
drug-resistant
bacteria
can
exceed
10
million
annually,
making
it
the
leading
cause
of
death.
Conventional
antibiotics
are
becoming
less
due
to
rapid
bacterial
drug
resistance
and
slowed
new
antibiotic
development,
necessitating
strategies.
Recently,
materials
with
catalytic/enzymatic
properties,
known
as
nanozymes,
have
been
developed,
inspired
by
natural
enzymes
essential
for
eradication.
Unlike
recent
literature
reviews
broadly
cover
nanozyme
design
biomedical
applications,
this
review
focuses
on
latest
advancements
in
nanozymes
combating
resistance,
emphasizing
their
design,
structural
characteristics,
applications
combination
therapy,
future
prospects.
This
approach
aims
promote
development
especially
towards
clinical
translation.
Journal of Materials Chemistry B,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 1, 2025
A
RuN
4
single-atom
nanozyme
was
synthesized
and
it
exhibited
multi-enzymatic
activities,
which
effectively
alleviated
eczema
symptoms
by
ROS
clearance.
Advanced Science,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 14, 2025
Abstract
Zinc
(Zn)
and
its
alloys
are
promising
biomaterials
for
orthopedic
applications
due
to
their
degradability
mechanical
properties.
Zn
2+
plays
a
crucial
role
in
bone
formation,
but
excessive
early
release
may
cause
cytotoxicity
inhibit
osseointegration.
To
solve
this,
we
developed
near‐infrared
(NIR)
light‐controlled
polycaprolactone/copper‐sulfur
(PCL/CuS)
coating
that
slows
degradation
enhances
osseointegration
of
alloys.
The
zinc–lithium
(Zn–Li)
substrate
is
encapsulated
with
PCL,
reducing
maintaing
biocompatibility.
Controlled
mild
photothermal
therapy
via
CuS
nanoparticles
promoted
osteogenesis.
In
vitro
studies
demonstrated
enhanced
cell
proliferation
osteogenic
differentiation.
vivo
Micro‐Computed
Tomography
(Micro‐CT),
Scanning
Electron
Microscopy‐Energy
Dispersive
Spectroscopy
(SEM‐EDS),
immunohistochemical
analyses
confirmed
improved
Mechanistic
using
RNA
sequencing
Western
blotting
revealed
the
promotes
osteogenesis
by
activating
Wnt/β‐catenin
inhibiting
NF‐κB
pathways.
This
NIR
PCL/CuS
successfully
regulates
alloy
degradation,
controlled
effct,
presenting
avenue
biomaterials.
Materials Today Bio,
Год журнала:
2025,
Номер
31, С. 101498 - 101498
Опубликована: Янв. 19, 2025
Antimicrobial
peptides
show
promise
in
enhancing
photothermal
therapy,
but
their
application
is
often
limited
by
the
challenge
of
constructing
a
delivery
system
that
balances
efficacy
and
safety.
Our
research
demonstrated
bactericidal
V2C
MXene-mediated
therapy
enhanced
concentration-dependent
relationship
with
introduction
coating
antimicrobial
peptide
ε-polylysine
(EPL).
EPL
exhibited
dual
role
bacterial
binding
disrupting
membranes,
thereby
increasing
heat
transfer
efficiency
reducing
resistance
to
ablation.
The
core
strategy
this
study
was
exploit
combined
membranolytic-photothermal
effect
extensively
applying
while
regulating
nanosheets
usage
prevent
overheating.
This
approach
aims
achieve
potent
through
below
60
°C.
Consequently,
we
developed
dissolving
microneedles
incorporated
nanosheets,
where
served
as
agent
primary
matrix,
its
loading
capacity
minimizing
need
for
inactive
excipients.
Notably,
microneedle
achieved
99.9
%
reduction
abundance
methicillin-resistant
Staphylococcus
aureus
on
infected
skin
after
single
resulted
92-fold
load
compared
group
treated
commercial
Bactroban
ointment,
no
apparent
toxicity
mice.
