Magnetic Hyperthermia in Glioblastoma Multiforme Treatment DOI Open Access
Veronica Mănescu, Iulian Antoniac, Gheorghe Păltânea

и другие.

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(18), С. 10065 - 10065

Опубликована: Сен. 19, 2024

Glioblastoma multiforme (GBM) represents one of the most critical oncological diseases in neurological practice, being considered highly aggressive with a dismal prognosis. At worldwide level, new therapeutic methods are continuously researched. Magnetic hyperthermia (MHT) has been investigated for more than 30 years as solution used single therapy or combined others glioma tumor assessment preclinical and clinical studies. It is based on magnetic nanoparticles (MNPs) that injected into tumor, and, under effect an external alternating field, they produce heat temperatures higher 42 °C, which determines cancer cell death. well known iron oxide have received FDA approval anemia treatment to be contrast substances medical imagining domain. Today, energetic, efficient MNPs developed especially dedicated MHT treatments. In this review, subject’s importance will emphasized by specifying number patients worldwide, presenting main features GBM, detailing physical theory accompanying treatment. Then, synthesis routes thermally MNP manufacturing, strategies adopted practice increasing performance, significant vitro vivo studies presented. This review paper also includes therapies, reasons using these approaches MHT, important human subjects found literature. ends describing challenges associated future perspectives. concluded can successfully regularly applied GBM if specific improvements made.

Язык: Английский

Electro‐ and Magneto‐Active Biomaterials for Diabetic Tissue Repair: Advantages and Applications DOI Open Access
Kai Mao, Muxin Yue, Huiping Ma

и другие.

Advanced Materials, Год журнала: 2025, Номер unknown

Опубликована: Март 31, 2025

Abstract The diabetic tissue repair process is frequently hindered by persistent inflammation, infection risks, and a compromised microenvironment, which lead to delayed wound healing significantly impact the quality of life for patients. Electromagnetic biomaterials offer promising solution enabling intelligent detection wounds through electric magnetic effects, while simultaneously improving pathological microenvironment reducing oxidative stress, modulating immune responses, exhibiting antibacterial action. Additionally, these materials inherently promote regeneration regulating cellular behavior facilitating vascular neural repair. Compared traditional biomaterials, electromagnetic provide advantages such as noninvasiveness, deep penetration, responsiveness, multi‐stimuli synergy, demonstrating significant potential overcome challenges This review comprehensively examines superiority in repair, elucidates underlying biological mechanisms, discusses specific design strategies applications tailored characteristics wounds, with focus on skin bone defect By addressing current limitations pursuing multi‐faceted strategies, hold improve clinical outcomes enhance

Язык: Английский

Процитировано

0
Synchronous Interference of Dual Metabolic Pathways Mediated by H2S Gas/GOx for Augmenting Tumor Microwave Thermal Therapy DOI
Shimei Li, Qiong Wu,

Zengzhen Chen

и другие.

ACS Applied Materials & Interfaces, Год журнала: 2025, Номер unknown

Опубликована: Янв. 11, 2025

Sublethal tumor cells have an urgent need for energy, making it common them to switch metabolic phenotypes between glycolysis and oxidative phosphorylation (OXPHOS) compensatory energy supply; thus, the synchronous interference of dual pathways limiting level is essential in inhibiting sublethal growth. Herein, a multifunctional nanoplatform Co-MOF-loaded anethole trithione (ADT) myristyl alcohol (MA), modified with GOx hyaluronic acid (HA) was developed, namely, CAMGH. It could synchronously interfere including OXPHOS restrict adenosine triphosphate (ATP) supply, achieving inhibition tumors after microwave (MW) thermal therapy. Under low-power MW irradiation, CAMGH induced certain damage while ensuring safety surrounding normal tissues. The loaded consumed glucose tumors, undoubtedly blocking main supply pathway, glycolytic pathway. Then, H

Язык: Английский

Процитировано

0
Therapy resistance: modulating evolutionarily conserved heat shock protein machinery in cancer DOI Creative Commons

Ilona Skrabalak,

Alicja Rajtak, Beata Małachowska

и другие.

Cancer Letters, Год журнала: 2025, Номер unknown, С. 217571 - 217571

Опубликована: Фев. 1, 2025

Язык: Английский

Процитировано

0
E. coli as a Smart Thermo-Vector for Combating Solid Tumors: A Synergistic Heat-Induced Cancer Therapy Approach DOI
Tashmeen Kaur,

Neeta Devi,

Deepika Sharma

и другие.

Bioconjugate Chemistry, Год журнала: 2025, Номер unknown

Опубликована: Март 19, 2025

Heat-induced cancer therapies such as magnetic hyperthermia-based therapy (MHCT) and photothermal tumor ablation (PTT) have garnered significant attention minimally invasive new-generation modalities. However, solid tumors associated with hypoxia present a considerable challenge to effective therapy. In this study, we took up the of mitigating limiting penetration ability nanoparticles by integrating polydopamine-coated motile anaerobic bacteria (PDBs) function smart thermo-vector. The developed PDBs are capable self-navigating hypoxic thermo-therapy agents induce heat through exposure an alternating field or near-infrared laser light. thermo-vector system exhibited dual-functioning synergistic antitumor effect MHCT PTT outstanding targeting efficiency, outperforming conventional 'nanoparticles only' approach. heat-induced cellular oxidative stress disrupted mitochondrial led 80% cytotoxicity within 24 h treatment. PDB-based approach complete regression in c57BL/6 mice 21 days treatment tumor-free survival for 60 without recurrence, proving capability combatting tumors.

Язык: Английский

Процитировано

0
Hierarchical Targeting Nanoplatform for NIR‐II Photoacoustic Imaging and Photo‐Activated Synergistic Immunotherapy of Glioblastoma DOI Open Access
Yuan Zhang, Xiaoying Kang, Jingyi Ma

и другие.

Advanced Functional Materials, Год журнала: 2025, Номер unknown

Опубликована: Март 24, 2025

Abstract Glioblastoma (GBM) stands as the most aggressive malignant brain tumor, characterized by poor prognosis, high recurrence rate, and resistance to multiple therapies, posing a significant clinical challenge. Here, hierarchical targeting platform is presented for NIR‐II photoacoustic (PA) imaging‐guided photo‐chemo synergistic immunotherapy of GBM. A new molecular probe developed with exceptional light‐harvesting capabilities enhanced motion, boosting both photothermal conversion PA signal. This probe, combined thermo‐responsive prodrug, assembled into nanoparticles that are further camouflaged tumor cell membranes bioorthogonally modified transferrin‐mimicking peptide, facilitating blood‐brain barrier penetration GBM targeting. High‐contrast imaging allows precise detection delineation GBM, providing accurate guidance subsequent treatment. The light‐triggered effect, coupled hyperthermia‐activated significantly induces immunogenic death, enhancing tumor‐killing efficiency amplifying anti‐tumor immune response. self‐synergistic not only stimulates robust immunity inhibits primary growth but also prevents post‐surgical recurrence, prolonging survival time. work exemplifies novel paradigm tackling diagnostic therapeutic challenges posed deeply seated poorly tumors.

Язык: Английский

Процитировано

0
Enhanced Synthesis of Copper Ferrite Magnetic Nanoparticles via Polymer-Assisted Sol-Gel Autocombustion Method for Magnetic Hyperthermia Applications DOI
Julia Mazurenko, Larysa Kaykan, Ján Michalík

и другие.

Journal of nano research, Год журнала: 2024, Номер 84, С. 95 - 116

Опубликована: Сен. 20, 2024

In this study, CuFe 2 O 4 nanoparticles with an average crystallite size of approximately 10 nm were produced using the sol-gel autocombustion method. The synthesis was conducted in presence polymers varying monomer counts, aiming to optimize magnetic properties for possible localized heating applications. Comprehensive characterization all samples X-ray diffraction (XRD), scanning electron microscopy (SEM), Fourier-transform infrared spectroscopy (FT-IR), and Mössbauer spectroscopy. All synthesized exhibited good colloidal stability, zeta potentials around -18.49mV, +3mV +24 +30 mV. Specific Absorption Rate (SAR) assessed calorimetric SAR values calculated both Initial Slope Box-Lucas methods. For sample citric acid, 12.6 W/g 13.23 W/g, respectively. polyethylene glycol, ranged from 3 7 W/g. parameters alternating field 33.3 kA/m 357 kHz.

Язык: Английский

Процитировано

2
Magnetic Hyperthermia in Glioblastoma Multiforme Treatment DOI Open Access
Veronica Mănescu, Iulian Antoniac, Gheorghe Păltânea

и другие.

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(18), С. 10065 - 10065

Опубликована: Сен. 19, 2024

Glioblastoma multiforme (GBM) represents one of the most critical oncological diseases in neurological practice, being considered highly aggressive with a dismal prognosis. At worldwide level, new therapeutic methods are continuously researched. Magnetic hyperthermia (MHT) has been investigated for more than 30 years as solution used single therapy or combined others glioma tumor assessment preclinical and clinical studies. It is based on magnetic nanoparticles (MNPs) that injected into tumor, and, under effect an external alternating field, they produce heat temperatures higher 42 °C, which determines cancer cell death. well known iron oxide have received FDA approval anemia treatment to be contrast substances medical imagining domain. Today, energetic, efficient MNPs developed especially dedicated MHT treatments. In this review, subject’s importance will emphasized by specifying number patients worldwide, presenting main features GBM, detailing physical theory accompanying treatment. Then, synthesis routes thermally MNP manufacturing, strategies adopted practice increasing performance, significant vitro vivo studies presented. This review paper also includes therapies, reasons using these approaches MHT, important human subjects found literature. ends describing challenges associated future perspectives. concluded can successfully regularly applied GBM if specific improvements made.

Язык: Английский

Процитировано

1