GSH-responsive and Mitochondria-targeting Multifunctional Nanoplatform for MR imaging-guided enhanced chemotherapy of Glioma by Reshaping the Tumor Immune Microenvironment DOI Creative Commons
Guangrong Zheng, Tengfei Ke, Wen Zhao

и другие.

Research Square (Research Square), Год журнала: 2024, Номер unknown

Опубликована: Окт. 24, 2024

Abstract Despite considerable progress in glioma research, present therapeutic approaches continue to be insufficiently efficacious, predominantly owing challenging hindrances conveying chemotherapy drugs across the blood-brain barrier (BBB) and reshaping immunosuppressive tumor microenvironment (TME). In this study, a multifunctional nanoplatform was developed comprising poly-lactide-co-glycolide (PLGA) encapsulated with MnO2 nanoparticles, triphenylphosphonium (TPP) conjugated doxorubicin (DOX), Angiopep-2 (Ang) for magnetic resonance imaging-guided enhanced of glioma. The role Ang promotes BBB penetration cell targeting, while TPP allows an increased concentration Ang-PMT NPs mitochondria. Upon exposure high glutathione (GSH) within TME, disintegrate rapidly, resulting production Mn2+ subsequent release DOX. released DOX directly eradicates cells catalyzes mitochondrial DNA release, leading immunogenic death (ICD) activation cGAS-STING pathway. Furthermore, produced also activates pathway, thereby TME enhancing demonstrated notable inhibition growth comparison control groups. It is anticipated that innovative approach may offer promising prospects management malignant clinical management.

Язык: Английский

Challenging and new opportunities for prodrug technology DOI
Helin Li,

Xuelian Shen,

Yu Chu

и другие.

Investigational New Drugs, Год журнала: 2025, Номер unknown

Опубликована: Фев. 18, 2025

Язык: Английский

Процитировано

0
CD44-targeting and ZIF-8-gated gold nanocage for programmed breast cancer therapy through Pt-induced immunogenic cell death DOI
Xin Li, Fei Xiong, Xudong Cao

и другие.

Chinese Chemical Letters, Год журнала: 2025, Номер unknown, С. 110970 - 110970

Опубликована: Фев. 1, 2025

Язык: Английский

Процитировано

0
Curcuminoids WM03 inhibits ovarian cancer cisplatin-resistant cells proliferation and reverses cisplatin resistance by targeting DYRK2 DOI
Minjie Zhang,

Xiaoxi Wan,

Mengna Shi

и другие.

Phytomedicine, Год журнала: 2025, Номер unknown, С. 156632 - 156632

Опубликована: Март 1, 2025

Язык: Английский

Процитировано

0
Circular RNAs modulate cancer drug resistance: advances and challenges DOI Open Access

Jinghan Hua,

Zhe Wang, Xiangfei Cheng

и другие.

Cancer Drug Resistance, Год журнала: 2025, Номер unknown

Опубликована: Март 28, 2025

Acquired drug resistance is a main factor contributing to cancer therapy failure and high mortality, highlighting the necessity develop novel intervention targets. Circular RNAs (circRNAs), an abundant class of RNA molecules with closed loop structure, possess characteristics including stability, which provide unique advantages in clinical application. Growing evidence indicates that aberrantly expressed circRNAs are associated against various treatments, targeted therapy, chemotherapy, radiotherapy, immunotherapy. Therefore, targeting these aberrant may offer strategy improve efficiency therapy. Herein, we present summary most recently studied their regulatory roles on resistance. With advances artificial intelligence (AI)-based bioinformatics algorithms, could emerge as promising biomarkers targets

Язык: Английский

Процитировано

0
Synchronous Interference of Dual Metabolic Pathways Mediated by H2S Gas/GOx for Augmenting Tumor Microwave Thermal Therapy DOI
Shimei Li, Qiong Wu,

Zengzhen Chen

и другие.

ACS Applied Materials & Interfaces, Год журнала: 2025, Номер unknown

Опубликована: Янв. 11, 2025

Sublethal tumor cells have an urgent need for energy, making it common them to switch metabolic phenotypes between glycolysis and oxidative phosphorylation (OXPHOS) compensatory energy supply; thus, the synchronous interference of dual pathways limiting level is essential in inhibiting sublethal growth. Herein, a multifunctional nanoplatform Co-MOF-loaded anethole trithione (ADT) myristyl alcohol (MA), modified with GOx hyaluronic acid (HA) was developed, namely, CAMGH. It could synchronously interfere including OXPHOS restrict adenosine triphosphate (ATP) supply, achieving inhibition tumors after microwave (MW) thermal therapy. Under low-power MW irradiation, CAMGH induced certain damage while ensuring safety surrounding normal tissues. The loaded consumed glucose tumors, undoubtedly blocking main supply pathway, glycolytic pathway. Then, H

Язык: Английский

Процитировано

0
Mitochondrial-Targeted Multifunctional Platinum-Based Nano “Terminal-Sensitive Projectile” for Enhanced Cancer Chemotherapy Efficacy DOI
Qiang Zhang, Jiamin Lin,

Jun Li

и другие.

ACS Nano, Год журнала: 2025, Номер unknown

Опубликована: Фев. 25, 2025

Platinum-based anticancer drugs exert their effects by forming adducts within nuclear DNA (nDNA), inhibiting transcription and inducing apoptosis in cancer cells. However, tumor cells have evolved mechanisms to resist these drugs. Given mitochondria's role lack of nucleotide excision repair (NER), targeting mitochondrial (mtDNA) offers a strategy. Herein, platinum-based terminal-sensitive projectile (TSB) which comprises heterofunctional tetravalent platinum prodrug as the primary warhead, complemented guidance system incorporating triphenylphosphine (TPP) secondary FFa (Fenofibric acid) was developed. TSB then encapsulated IR780 coupling DSPE-PEG2K for enhanced delivery (NTSB). This design allows be precisely targeted into intertumoral mitochondria its terminal, releasing free oxaliplatin (OXA) upon reaching terminal destination. The accumulation OXA leads cross-linking with mtDNA, causing dysfunction, while disrupts electron transport chain (ETC), impairing oxidative phosphorylation (OXPHOS). Furthermore, under near-infrared (NIR) irradiation, component generates phototherapeutic thermal effect reactive oxygen species (ROS), deplete intracellular glutathione (GSH) levels facilitate Pt mtDNA. Both vitro vivo studies demonstrated that this comprehensive approach significantly enhances sensitivity chemotherapeutic

Язык: Английский

Процитировано

0
Biomineralize Mitochondria in Metal‐Organic Frameworks to Promote Mitochondria Transplantation From Non‐Tumorigenic Cells Into Cancer Cells DOI Creative Commons
Junnian Zhou, Chang Liu, Yonghui Wang

и другие.

Smart Medicine, Год журнала: 2025, Номер 4(1)

Опубликована: Фев. 26, 2025

Mitochondria are crucial to cellular physiology, and growing evidence highlights the significant impact of mitochondrial dysfunction in diabetes, aging, neurodegenerative disorders, cancers. Therefore, transplantation shows great potential for therapeutic use treating these diseases. However, process is notably challenging due very low efficiency rapid loss bioactivity post-isolation, leading poor reproducibility reliability. In this study, we develop a novel strategy form nanometer-thick protective shell around isolated mitochondria using Metal-Organic Frameworks (MOFs) through biomineralization. Our findings demonstrate that encapsulation method effectively maintains at least 4 weeks room temperature. Furthermore, intracellular delivery significantly enhanced surface functionalization MOFs with polyethyleneimine (PEI) cell-penetrating peptide Tat. The successful from non-tumorigenic cells into cancer results notable tumor-suppressive effects. Taken together, our technology represents advancement research, particularly on understanding their role cancer. It also lays groundwork utilizing as agents treatment.

Язык: Английский

Процитировано

0
Multifunctional nanoparticle-mediated targeting of metabolic reprogramming and DNA damage response pathways to treat drug-resistant triple-negative breast cancer DOI
Sifeng Zhu, Chao Sun,

Zimin Cai

и другие.

Journal of Controlled Release, Год журнала: 2025, Номер 381, С. 113601 - 113601

Опубликована: Март 5, 2025

Язык: Английский

Процитировано

0
How the Versatile Self‐Assembly in Drug Delivery System to Afford Multimodal Cancer Therapy? DOI

Yuqi Cao,

Xiaomin Zhao,

Yuhang Miao

и другие.

Advanced Healthcare Materials, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 25, 2024

The rapid development of self-assembly technology during the past few decades has effectively addressed plenty issues associated with carrier-based drug delivery systems, such as low loading efficiency, complex fabrication processes, and inherent toxicity carriers. integration nanoscale systems techniques enabled efficient targeted self-administration drugs, enhanced bioavailability, prolonged circulation time, controllable release. Concurrently, limitations single-mode cancer treatment, including poor therapeutic outcomes, significant side effects, have highlighted urgent need for multimodal combined antitumor therapies. Set against backdrop therapy, this review summarizes research progress applications a large number self-assembled platforms, natural small molecule self-assembled, carrier-free amphiphilic polymer-based peptide-based metal-based nano systems. This particularly analyzes latest advances in application platforms therapies mediated by chemotherapy, phototherapy, radiotherapy, sonodynamic immunotherapy, providing innovative insights further optimization expansion clinical translation therapy.

Язык: Английский

Процитировано

0
GSH-responsive and Mitochondria-targeting Multifunctional Nanoplatform for MR imaging-guided enhanced chemotherapy of Glioma by Reshaping the Tumor Immune Microenvironment DOI Creative Commons
Guangrong Zheng, Tengfei Ke, Wen Zhao

и другие.

Research Square (Research Square), Год журнала: 2024, Номер unknown

Опубликована: Окт. 24, 2024

Abstract Despite considerable progress in glioma research, present therapeutic approaches continue to be insufficiently efficacious, predominantly owing challenging hindrances conveying chemotherapy drugs across the blood-brain barrier (BBB) and reshaping immunosuppressive tumor microenvironment (TME). In this study, a multifunctional nanoplatform was developed comprising poly-lactide-co-glycolide (PLGA) encapsulated with MnO2 nanoparticles, triphenylphosphonium (TPP) conjugated doxorubicin (DOX), Angiopep-2 (Ang) for magnetic resonance imaging-guided enhanced of glioma. The role Ang promotes BBB penetration cell targeting, while TPP allows an increased concentration Ang-PMT NPs mitochondria. Upon exposure high glutathione (GSH) within TME, disintegrate rapidly, resulting production Mn2+ subsequent release DOX. released DOX directly eradicates cells catalyzes mitochondrial DNA release, leading immunogenic death (ICD) activation cGAS-STING pathway. Furthermore, produced also activates pathway, thereby TME enhancing demonstrated notable inhibition growth comparison control groups. It is anticipated that innovative approach may offer promising prospects management malignant clinical management.

Язык: Английский

Процитировано

0