Self-Cascaded Pyroptosis-STING Initiators for Catalytic Metalloimmunotherapy
Journal of the American Chemical Society,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 17, 2025
Gasdermin
(GSDM)-mediated
pyroptosis
involves
the
induction
of
mitochondrial
damage
and
subsequent
release
DNA
(mtDNA),
which
is
anticipated
to
activate
cGAS-STING
pathway,
thereby
augmenting
antitumor
immune
response.
However,
challenges
lie
in
effectively
triggering
cancer
cells
subsequently
enhancing
activation
with
specificity.
Herein,
we
developed
intelligent
self-cascaded
pyroptosis-STING
initiators
cobalt
fluoride
(CoF2)
nanocatalysts
for
catalytic
metalloimmunotherapy.
CoF2
a
semiconductor
structure
enzyme-like
activity
generated
substantial
amount
reactive
oxygen
species
(ROS)
under
stimulation
by
endogenous
H2O2
exogenous
ultrasound.
Importantly,
discovered
that
Co-based
nanomaterials
themselves
induce
cells.
Therefore,
initially
acted
as
inducers,
caspase-1/GSDMD-dependent
via
Co2+
ROS,
leading
mtDNA
release.
Subsequently,
were
further
utilized
STING
agonists
specifically
capable
detecting
pathway.
These
cascade
events
triggered
robust
response,
modulating
immunosuppressive
tumor
microenvironment
into
an
immune-supportive
state,
providing
favorable
support
therapy.
This
innovative
strategy
not
only
significantly
impeded
growth
primary
but
also
elicited
response
augment
efficacy
checkpoint
inhibitors
preventing
distant
progression.
Overall,
this
study
proposed
self-cascade
activating
amplifying
pathway
specificity
mediated
pyroptosis,
representing
valuable
avenue
future
Язык: Английский
3D-Printed Scaffold Achieves Synergistic Chemo-Sonodynamic Therapy for Tumorous Bone Defect
ACS Applied Bio Materials,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 30, 2025
Various
smart
scaffolds
have
recently
been
developed
to
address
the
regeneration
of
tumor
bone
defect.
However,
recurrence
residual
cells
poses
a
serious
challenge
postoperative
management,
highlighting
need
for
effective
therapeutic
interventions.
In
this
study,
multifunctional
antitumor
nanoplatform
(Ti3C2/CuO2)
synergistic
chemo-sonodynamic
therapy
was
and
then
rationally
integrated
into
poly(l-lactic
acid)
(PLLA)
scaffold
via
selective
laser
sintering.
CuO2
not
only
releases
Cu2+
ions
facilitate
chemodynamic
through
Fenton
reaction
but
also
generates
H2O2,
which
further
oxidizes
Ti3C2
produce
TiO2
sonosensitizers.
More
importantly,
carbon-based
substrates
after
oxidation
created
favorable
conditions
carrier
transmission
in
sonodynamic
process,
thereby
amplifying
therapy.
Additionally,
moderate
local
hyperthermia
form
periodic
produces
localized
heat
stimulate
tissue
regeneration.
Meanwhile,
sustained
release
bioactive
(such
as
Cu
Ti
ions)
from
fosters
vascularization,
accelerating
This
work
presents
viable
approach
developing
repairing
tumorous
defects.
Язык: Английский
Ultrasound-Activatable Nanoprobes for Imaging-Guided Inhibition of Immunosuppressor Production in Tumor Microenvironment
ACS Applied Nano Materials,
Год журнала:
2025,
Номер
unknown
Опубликована: Май 2, 2025
Язык: Английский
Targeting pyroptosis for cancer immunotherapy: mechanistic insights and clinical perspectives
Molecular Cancer,
Год журнала:
2025,
Номер
24(1)
Опубликована: Май 3, 2025
Pyroptosis
is
a
distinct
form
of
programmed
cell
death
characterized
by
the
rupture
membrane
and
robust
inflammatory
responses.
Increasing
evidence
suggests
that
pyroptosis
significantly
affects
tumor
microenvironment
antitumor
immunity
releasing
damage-associated
molecular
patterns
(DAMPs)
pro-inflammatory
mediators,
thereby
establishing
it
as
pivotal
target
in
cancer
immunotherapy.
This
review
thoroughly
explores
mechanisms
underlying
pyroptosis,
with
particular
focus
on
inflammasome
activation
gasdermin
family
proteins
(GSDMs).
It
examines
role
pyroptotic
reshaping
immune
(TIME)
involving
both
cells,
discusses
recent
advancements
targeting
pathways
through
therapeutic
strategies
such
small
molecule
modulators,
engineered
nanocarriers,
combinatory
treatments
checkpoint
inhibitors.
We
also
advances
future
directions
to
enhance
immunotherapy
inhibitors,
adoptive
therapy,
vaccines.
study
suggested
offers
promising
avenue
amplify
responses
surmount
resistance
existing
immunotherapies,
potentially
leading
more
efficacious
treatments.
Язык: Английский
Ultrasound-assisted immunotherapy for malignant tumour
Frontiers in Immunology,
Год журнала:
2025,
Номер
16
Опубликована: Май 13, 2025
Malignant
tumour
represents
a
significant
global
public
health
concern.
The
advent
of
immunotherapy
has
brought
about
revolutionary
shift
in
the
landscape
treatment,
offering
ray
hope
to
patients
across
globe.
Immunotherapy
strategies
have
demonstrated
considerable
promise
clinical
trials.
However,
immunosuppressive
environment
within
microenvironment
constituted
obstacle
advancement
immunotherapies.
It
is
therefore
imperative
develop
more
efficacious
and
personalised
approaches.
utilisation
non-invasive
ultrasound-assisted
promising
strategy.
Ultrasound
capacity
induce
an
immune
response
stimulate
other
drugs
achieve
specific
response,
thereby
reducing
toxic
side
effects
treatment
enhancing
outcome
immunotherapy.
This
paper
presents
systematic
introduction
various
mechanisms
related
ultrasound
reviews
recent
advancements
immunotherapy,
including
ultrasonic
ablation,
combined
application
with
contrast
agents,
sonodynamic
therapy.
Язык: Английский
Biomimetic CuCoO2 nanosheets reinforced with self-assembling peptide nanofibers for tumor photothermal therapy
RSC Advances,
Год журнала:
2024,
Номер
14(53), С. 39163 - 39172
Опубликована: Янв. 1, 2024
The
flexible
design
and
unique
physical
chemical
properties
of
self-assembled
peptides
have
shown
great
potential
for
applications
in
the
fields
materials
science,
life
environmental
science.
Peptide
nanofibers
(PNFs),
as
a
kind
bioactive
nanomaterials,
possess
excellent
biocompatibility,
designability,
multifaceted
functionalizability.
In
this
work,
we
describe
PNFs
that
by
peptide
molecules
carriers
bimetallic
nanosheets
(BMNS),
leading
to
development
hybrid
BMNS-PNFs,
with
properties.
BMNS-PNFs
exhibit
photothermal
conversion
efficiency
(PCE)
up
31.57%,
can
be
used
nanoplatform
therapy
(PTT)
lung
tumour
cells.
Through
results,
it
is
reduce
cytotoxicity
cancer
cell
killing
effects,
rates
more
than
95%
90%
cells
HCC2279
PC9,
respectively.
Finally,
comprehensive
PTT
performance
analysed
Ranking
Efficiency
Performance
(REP),
REP
value
calculated
0.741.
sequences
assemble
into
study
are
instructive
functional
structural
modulation
molecular
self-assembly,
constructed
bimetallic-biomolecular
provide
strategy
medical
bioengineering.
Язык: Английский