Overcoming Tumor Hypoxic Bismuth-based Ternary Heterojunctions Enable Defect Modulation-augmented Tumor Sonocatalytic Immunotherapy

Biomaterials, Год журнала: 2024, Номер 315, С. 122962 - 122962

Опубликована: Ноя. 12, 2024

Язык: Английский

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Cancer Vaccines and Beyond: The Transformative Role of Nanotechnology in Immunotherapy

Pharmaceutics, Год журнала: 2025, Номер 17(2), С. 216 - 216

Опубликована: Фев. 7, 2025

Cancer is one of the leading causes morbidity and mortality globally, responsible for approximately 10 million deaths in 2022 an estimated 21 new cases 2024. Traditional cancer treatments such as surgery, radiation therapy, chemotherapy often present limitations efficacy side effects. However, immunotherapeutic vaccines have emerged a promising approach, leveraging body’s immune system to target eliminate cells. This review examines evolving landscape vaccines, differentiating between preventive therapeutic strategies highlighting significance tumor-specific antigens, including tumor-associated antigens (TAAs) neoantigens. Recent advancements vaccine technology, particularly through nanotechnology, resulted development nanovaccines, which enhance antigen stability, optimize delivery cells, promote robust responses. Notably, clinical data indicate that patients receiving checkpoint inhibitors can achieve overall survival rates 34.8 months compared just 15.7 traditional therapies. Despite these advancements, challenges remain, immunosuppressive tumor microenvironment heterogeneity. Emerging evidence suggests combining nanovaccines with immunomodulators may by overcoming obstacles. Continued research interdisciplinary collaboration will be essential fully exploit promise ultimately more effective accessible patients. The future immunotherapy appears increasingly hopeful innovative pave way enhanced patient outcomes improved quality life oncology.

Язык: Английский

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Piezo‐STING Agonists Enhance Tumor Penetration and Catalytic‐immunotherapy

Advanced Functional Materials, Год журнала: 2025, Номер unknown

Опубликована: Март 16, 2025

Abstract The cyclic guanosine monophosphate‐adenosine monophosphate synthase (cGAS)‐stimulator of interferon genes (STING) signaling pathway is an important innate immune that has shown remarkable potential in cancer immunotherapy. However, the clinical therapeutic efficacy limited due to insufficient penetration STING agonists into tumors. In this study, a special piezo‐STING agonist (ZnS‐Cur@CM, Z/C@M) composed zinc sulfide nanosheets, curcumin, and tumor cell membranes based on principle piezocatalytic for water splitting generate gas designed, which effectively reduces intratumoral delivery resistance, markedly enhancing depth drug Under ultrasound, Z/C@M rapidly decomposes interstitial fluid produce hydrogen, leading decreased pressure increased accumulation within tumor. Additionally, reactive oxygen species generated by piezocatalysis damage mitochondria cells, resulting release mitochondrial DNA activation cGAS‐STING pathway. Moreover, released Zn 2+ acidic microenvironment further enhances signal transduction. reduce through improve tumors, also activates treatment. This study provides novel perspective

Язык: Английский

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Peptide‐Based Strategies in PLGA‐Enhanced Tumor Therapy

Journal of Peptide Science, Год журнала: 2025, Номер 31(6)

Опубликована: Апрель 23, 2025

ABSTRACT Peptide‐based therapeutics have gained attention in cancer treatment because of their good specificity, low toxicity, and ability to modulate immune responses. However, challenges such as enzymatic degradation poor bioavailability limit clinical application. Peptide‐functionalized poly(lactic‐co‐glycolic acid) (PLGA) systems emerged a transformative platform therapy that offers unique advantages, including enhanced stability, sustained release, precise delivery therapeutic agents. This review highlights the synergistic integration peptides with PLGA addresses key peptide‐based therapeutics. The application peptide‐functionalized encompasses diverse range strategies for therapy. In chemotherapy, disrupt critical tumor pathways, induce apoptosis, inhibit angiogenesis, demonstrating versatility targeting various aspects progression. immunotherapy, act antigens stimulate robust responses or checkpoint inhibitors restore T cell activity, overcoming evasion. These also harness permeability retention effect, facilitating preferential accumulation tissues while leveraging microenvironment (TME)‐responsive mechanisms, pH‐sensitive enzyme‐triggered drug achieve controlled, localized delivery. Collectively, represent promising, versatile approach integrates innovative highly specific, potent

Язык: Английский

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Research progress and prospect of tumor nanovaccine combination therapy strategy

Chinese Chemical Letters, Год журнала: 2024, Номер unknown, С. 110771 - 110771

Опубликована: Дек. 1, 2024

Язык: Английский

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Receptor agonist/antagonist-incorporated anticancer nanodrugs: Design, materials, and strategies

Materials Today, Год журнала: 2024, Номер unknown

Опубликована: Дек. 1, 2024

Язык: Английский

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