Biochemical and Biophysical Research Communications, Год журнала: 2024, Номер 747, С. 151260 - 151260
Опубликована: Дек. 27, 2024
Язык: Английский
International Journal of Nanomedicine, Год журнала: 2025, Номер Volume 20, С. 705 - 721
Опубликована: Янв. 1, 2025
The metabolic activity of tumor cells leads to the acidification surrounding microenvironment, which provides new strategies for application nanotechnology in cancer therapy.Researchers have developed various types pH-responsive nanomaterials based on acidic microenvironment.This review an in-depth discussion design mechanisms, drug-loading strategies, and pathways microenvironment-responsive nanodrug delivery systems.These materials trigger drug release upon reaching enhancing therapeutic targeting reducing toxicity healthy cells.pH-responsive include organic nanomaterials, inorganic composite nanomaterials.Additionally, this outlines prospects, challenges aiming promote development clinical translation field.
Язык: Английский
Процитировано
2
Advanced Functional Materials, Год журнала: 2025, Номер unknown
Опубликована: Янв. 19, 2025
Abstract Ferroptosis is a newly identified type of regulated cell death characterized by iron‐dependent lipid peroxidation. Among the main ferroptosis‐suppressing systems, dihydroorotate dehydrogenase (DHODH)‐ ubiquinone axis closely related to mitochondria and energy metabolism, implying that protects cells from oxidative stress damage via maintenance redox homeostasis. However, ferroptosis initiation requires suitable environment breakthrough in homeostatic limitations systems. Hence, nanoparticles are rationally engineered achieve efficient induction releasing dual‐release free iron disrupting Atovaquone (ATO)‐loaded hollow mesoporous etching zeolitic imidazolate framework‐67 double‐coated oxide/calcium phosphate (Fe 3 O 4 /CaP) conjugated with polyethylene glycol. The external Fe /CaP structure enhances efficiency multiple reactive oxygen species (ROS) generation promoting stress. Still, it achieves increase content unstable pools for igniting ROS storm peroxidation spark. release ATO not only affects metabolism mitochondrial respiratory chain binding complex III but also downregulates DHODH restrict ubiquinol system disrupt Therefore, design this composite nanomedicine provides an approach inducing theoretical basis clinical anti‐tumor trials.
Язык: Английский
Процитировано
1
International Journal of Biological Macromolecules, Год журнала: 2025, Номер 299, С. 140116 - 140116
Опубликована: Янв. 20, 2025
Язык: Английский
Процитировано
0
ACS Applied Bio Materials, Год журнала: 2025, Номер unknown
Опубликована: Март 11, 2025
Through the PFOEP-SO3(−) + multidrug molecules constructed nanoparticle (NP) experiments and validated by molecular simulation docking experiments, we propose a interaction principle for inducing aggregation-induced locally excited emission (AILE) luminescence from fluorenone (FO)-based conjugated polymers (CPs). Based on this mechanism, NP built π–π stacking. The NPs demonstrate facile synthesis, robust stability, high drug-loading efficiency, enabling tumor-specific drug release in acidic lysosomal environments (pH 3.8–4.7) to minimize off-target toxicity. Concurrently, PFOEPA exhibit pH-dependent fluorescence enhancement: incorporation induces structural reorganization into "sandwich" configuration, amplifying with blue shift under neutral/alkaline conditions, while acidic-triggered protonation collapse disrupts NPs. Moreover, it can be used as an indicator monitoring release, is accompanied changes during process. This possesses multiple functions expected serve effective pH-responsive delivery system.
Язык: Английский
Процитировано
0
Biochemical and Biophysical Research Communications, Год журнала: 2024, Номер 747, С. 151260 - 151260
Опубликована: Дек. 27, 2024
Язык: Английский
Процитировано
0