Targeting Neuroinflammation in Central Nervous System Diseases by Oral Delivery of Lipid Nanoparticles

Pharmaceutics, Год журнала: 2025, Номер 17(3), С. 388 - 388

Опубликована: Март 18, 2025

Neuroinflammation within the central nervous system (CNS) is a primary characteristic of CNS diseases, such as Parkinson’s disease, Alzheimer’s disease (AD), amyotrophic lateral sclerosis, and mental disorders. The excessive activation immune cells results in massive release pro-inflammatory cytokines, which subsequently induce neuronal death accelerate progression neurodegeneration. Therefore, mitigating neuroinflammation has emerged promising strategy for treatment diseases. Despite advancements drug discovery development novel therapeutics, effective delivery these agents to remains serious challenge due restrictive nature blood–brain barrier (BBB). This underscores need develop system. Recent studies have identified oral lipid nanoparticles (LNPs) approach efficiently deliver drugs across BBB treat neurological review aims comprehensively summarize recent LNPs designed controlled therapeutic modulation diseases through administration. Furthermore, this addresses mechanisms by overcome biological barriers evaluate their clinical implications efficacy context systems. Specifically, it focuses on LNP formulations that facilitate administration, exploring potential enhance bioavailability, improve targeting precision, alleviate or manage symptoms associated with range

Язык: Английский

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A temperature-responsive PLA-based nanosponge as a novel nanoadjuvant and efficient delivery carrier of Ag85B for effective vaccine against Mycobacterium tuberculosis

Cell Communication and Signaling, Год журнала: 2025, Номер 23(1)

Опубликована: Апрель 1, 2025

Abstract Background Tuberculosis (TB) is a contagious disease and the second leading cause of death worldwide. The Bacille Calmette–Guérin (BCG) vaccine, only licensed TB has insufficient protective efficacy in adults, necessitating development new vaccines. Ag85B, protein-subunit promising candidate due to its high immunogenicity. However, hydrophobicity presents challenges manufacturing, expression, purification, Ag85B alone does not elicit sufficient immune stimulation. To overcome these limitations, this study aimed design temperature-responsive amine-terminated polylactic acid (PLA)-based nanosponge (aPNS) as both nanoadjuvant an efficient delivery carrier for Ag85B. Methods was produced using EZtag fusion tag vector, achieving product yield purity. It then loaded into aPNS, nanoparticle system with PLA core Pluronic shell, through process at 4 °C that preserved protein bioactivity. stability sustained-release profile Ag85B@aPNS were evaluated. In vitro cytotoxicity cellular uptake studies conducted macrophages. Protective immunogenicity assessed M. tuberculosis -challenged mice BCG-primed mice. Results successfully which exhibited good colloidal profile. Neither synthesized nor aPNS showed significant cytotoxicity. enhanced antigens by Compared BCG, demonstrated superior against improved Conclusion viable vaccination, showing potential standalone vaccine BCG-booster. Its ability enhance provide protection highlights promise addressing limitations current

Язык: Английский

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Biocompatible lipid nanovehicles for preventive and therapeutic vaccine development

Coordination Chemistry Reviews, Год журнала: 2025, Номер 538, С. 216718 - 216718

Опубликована: Апрель 22, 2025

Язык: Английский

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Lipid nanoparticle-based delivery of small interfering RNAs: New possibilities in the treatment of diverse diseases

European Polymer Journal, Год журнала: 2024, Номер unknown, С. 113624 - 113624

Опубликована: Дек. 1, 2024

Язык: Английский

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