NIR-enhanced oxidase-like activity of manganese dioxide nanoparticles for combating subcutaneous methicillin-resistant Staphylococcus aureus infections

Chinese Chemical Letters, Год журнала: 2025, Номер unknown, С. 111199 - 111199

Опубликована: Апрель 1, 2025

Язык: Английский

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Enhancing Peroxidase‐Like Activity and Photothermal Property of Copper Single‐Atom Nanozyme via A Cascade Competition Strategy

Advanced Functional Materials, Год журнала: 2025, Номер unknown

Опубликована: Янв. 16, 2025

Abstract Single‐atom nanozymes (SANs) are promising enzyme‐active catalysts due to their maximum atomic utilization. However, it is still a challenge precisely regulate the single‐atom structure, especially in multimetallic MOFs. Based on Cu‐N 4 structure of Zn Cu 1 , cascade competition strategy mediated by buffer (polydopamine) proposed for first time, which induces one‐step nonthermal reaction remove inactive site and adjust coordination environment. Experimental results theoretical calculations show that nanozyme with 2 O (Cu‐N/O) breaks strong steric restriction, exposed active can better adsorb H making have peroxidase‐like activity. Compared traditional bimetallic (Cu ) monometallic (Cu‐MoF) nanozymes, has stronger catalytic activity photothermal properties, as well good photocatalytic extremely stability. It successfully applied Lateral flow immunoassay achieve three‐mode ultrasensitive detection Escherichia coli O157:H7, test strips after subjected broad‐spectrum sterilization treatment.

Язык: Английский

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An orally biological chemotaxis-guided hypoxia-responsive biomimetic microcapsules for visualizing multi-faceted synergistic therapy of inflammatory bowel disease

Chemical Engineering Journal, Год журнала: 2025, Номер unknown, С. 160203 - 160203

Опубликована: Фев. 1, 2025

Язык: Английский

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Zinc Cerium Peroxide Antibacterial Agent with Acid-Activated Cascade Multienzymatic Activities

ACS Applied Nano Materials, Год журнала: 2025, Номер unknown

Опубликована: Фев. 2, 2025

Recently, metal peroxides with the ability to self-supply H2O2 have been intensively used in antibacterial and cancer therapy. However, performances are unsatisfactory due low efficiency of peroxide-mediated Fenton-like reaction. In this work, a novel zinc cerium bimetallic peroxide (CeZnOx) has first reported, which possesses acid-activated POD-like, OXD-like, CAT-like multienzymatic activities for efficiently bacterial inhibition. Specifically, CeZnOx self-supplying under weakly acidic conditions subsequently catalyzes production reactive oxygen species (ROS) through synergistically enhanced POD-like OXD-like activity. They can also exhibit activity catalyze excessive into O2 play an anti-inflammatory role normal pH conditions. The cascade inhibit growth alleviate hypoxia, improving microenvironment at wound site. As expected, exhibits superior effect on Staphylococcus aureus Escherichia coli. Therefore, CeZnOx-mediated offer simple promising strategy efficient treatment infections.

Язык: Английский

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Microbially synthesized nanomaterials: Advances and applications in biomedicine

Precision medicine and engineering., Год журнала: 2025, Номер unknown, С. 100019 - 100019

Опубликована: Фев. 1, 2025

Язык: Английский

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Nanoflowers: A multifunctional nanomaterial revolutionizing medicine, environmental protection, and sustainable agriculture

Inorganic Chemistry Communications, Год журнала: 2025, Номер unknown, С. 114311 - 114311

Опубликована: Март 1, 2025

Язык: Английский

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Ultrafast Charged MnO₂ Nanosheets/Carbon Fiber with Mechanical and Postcharging Antibacterial Activity

Nano Letters, Год журнала: 2025, Номер unknown

Опубликована: Март 15, 2025

Postcharging antibacterials have shown good application prospects in combating bacterial infections through electrical interaction. Herein, manganese oxide nanosheets situ grown on carbon fibers (CM) are designed to perform the integration of mechanical intervention and postcharging therapy for efficient killing. This electrode disrupts membranes via sharp-edged microstructures. After charging at a low voltage an ultrashort time, charged CM affects extracellular electron transfer (EET) bacteria during discharge process kill bacteria. Due dual-antibacterial mode, after −1 V (vs saturated calomel electrode, SCE) only 50.4 ± 3 s, lethality rates against Escherichia coli Staphylococcus aureus within 0.5 h both exceed 98%. Our developed ultrafast negatively exhibits high antibacterial activity cytotoxicity fibroblast cells, providing non-antibiotic approach combat infection.

Язык: Английский

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Multifunctional nanozymatic biosensors: awareness, regulation and pathogenic bacteria detection - a review

Talanta, Год журнала: 2025, Номер unknown, С. 127957 - 127957

Опубликована: Март 1, 2025

Язык: Английский

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Defect-Engineered CoFe Layered Double Hydroxide Quantum Dots: Oxygen Vacancy-Driven Boost in Peroxidase-Mimic Catalysis for Multiplex Biomarker Sensing

ACS Materials Letters, Год журнала: 2025, Номер unknown, С. 1777 - 1785

Опубликована: Апрель 8, 2025

Язык: Английский

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Atomic Pt-Layer-Coated Au Peroxidase Nanozymes with Enhanced Activity for Ultrasensitive Colorimetric Immunoassay of Interleukin-12

Biosensors, Год журнала: 2025, Номер 15(4), С. 239 - 239

Опубликована: Апрель 9, 2025

Interleukin-12 (IL-12), a crucial biomarker for immune and inflammatory responses, plays pivotal role in diagnosing managing diverse pathological conditions. Although colorimetric enzyme-linked immunosorbent assays (CELISAs) have been extensively employed to detect IL-12 biological samples, their sensitivity is inherently limited by the catalytic efficiency of enzyme labels, presenting substantial challenges achieving ultrasensitive detection enabling pre-symptomatic diagnosis diseases. In this study, we address limitation developing novel peroxidase nanozyme, featuring ultrathin Pt skins consisting only ~4 atomic layers, coated on Au nanoparticles (denoted as Au@Pt4LNPs). These Au@Pt4LNPs exhibit remarkable performance, ~1063-fold enhancement peroxidase-like activity compared horseradish (HRP), while minimizing consumption, thereby improving utilization reducing costs. This advancement facilitates construction an CELISA capable detecting at femtomolar concentrations. Using signal developed demonstrates quantitative range from 0.1 100 pg mL−1, with limit (LOD) low 0.084 mL−1 (1.1 fM), offering ~10 times greater than HRP-based CELISA. study highlights potential Au@Pt4LNP nanozymes advanced opening new avenues next-generation bioassays.

Язык: Английский

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