Dissolving PEGDA-Based Microneedles to Transdermally Deliver PDA@Cu with Photothermal Properties for Potential Antibacterial Applications

ACS Applied Materials & Interfaces, Год журнала: 2024, Номер 16(51), С. 70339 - 70351

Опубликована: Дек. 13, 2024

The stratum corneum of the skin functions as a barrier, obstructing drug absorption and complicating treatment infections caused by pathogens such bacteria, fungi, viruses through topical methods. In this research, microneedle patch was developed, which consists gelatin-sucrose (SG) that encapsulates polydopamine-copper nanoparticles (PDA@Cu) at tip for antibacterial purposes. Poly(ethylene glycol) diacrylate (PEGDA) served primary substrate shaft (PDA@Cu-SG/PEGDA). This engineered to enhance permeability facilitate efficient delivery drugs rapid dissolution tips. Coordinate bonds can be formed between PDA Cu ions, resulting in immobilization particles on surface, aids green synthesis PDA@Cu photothermal particles. SG polymer, contained PDA@Cu, employed fill cavities series centrifugation steps. Subsequently, UV-induced polymerization carried out produce PEGDA microneedles with hydrophilic tips Furthermore, physicochemical characteristics polymer microneedles, including morphology, composition, mechanical strength, were thoroughly characterized. These demonstrated sufficient strength. Owing ability disrupt bacterial membranes, excellent vitro efficacy. We validated activity against Escherichia coli Staphylococcus aureus conducting plate coating assays. results assays indicated minimally invasive strategy achieved broad-spectrum effects; thus, may suitable approach managing polymicrobial during clinical trials.

Язык: Английский

Enhanced electrochemical sensor based on Uio-66-NH2/carbon nanotubes hybrid for selective detection of ofloxacin

Materials Today Chemistry, Год журнала: 2024, Номер 42, С. 102441 - 102441

Опубликована: Дек. 1, 2024

Язык: Английский