Active microneedle patch equipped with spontaneous bubble generation for enhanced rheumatoid arthritis treatment
Theranostics,
Год журнала:
2025,
Номер
15(8), С. 3424 - 3438
Опубликована: Фев. 24, 2025
Rationale:
The
utilization
of
dissolving
microneedles
(MNs)
facilitates
the
painless
delivery
pharmaceuticals
via
transdermal
route.
However,
conventional
MNs
rely
on
passive
diffusion
through
gradual
matrix,
which
can
impede
therapeutic
efficacy
delivered
drugs.
Methods:
In
this
study,
we
present
development
a
novel
degradable
active
platform.
This
platform
employs
sodium
bicarbonate
and
citric
acid
loaded
in
patch
as
built-in
motor
for
deeper
faster
intradermal
payload
delivery.
microparticles
undergo
chemical
reaction
when
contact
with
tissue
fluid,
resulting
rapid
formation
explosive
carbon
dioxide
bubbles.
provides
necessary
force
to
break
dermal
barriers
enhance
Results:
results
demonstrated
that
possessed
excellent
mechanical
properties,
detachment
characteristics,
superior
drug
release
kinetics.
Furthermore,
permeation
behavior
exhibited
enhanced
distribution
skin-mimicking
gel
porcine
skin
compared
MNs.
vivo
experiments
employing
rat
model
rheumatoid
arthritis
showed
achieved
Conclusions:
universal
effective
autonomous
dynamic
microneedle
technology
is
straightforward
prepare
ultilize,
has
potential
improve
drugs,
offering
significant
prospects
diverse
range
applications.
Язык: Английский
Molecular mechanism of the effect of BixiezelanYin on knee osteoarthritis based on network pharmacology and molecular docking
Medicine,
Год журнала:
2025,
Номер
104(6), С. e41459 - e41459
Опубликована: Фев. 7, 2025
The
BixizelanYin
(BXZLY)
is
a
traditional
herbal
formula
for
treating
damp-heat
type
knee
osteoarthritis
(KOA).
This
study
aimed
to
investigate
the
potential
therapeutic
effects
of
BXZLY
on
KOA
by
using
network
pharmacology
and
molecular
docking.
Active
ingredients
their
corresponding
targets
were
screened
through
Traditional
Chinese
Medicine
Systems
Pharmacology
Database
Analysis
Platform.
known
disease
retrieved
from
GeneCards
Online
Mendelian
Inheritance
in
Man
database.
effective
obtained
with
Venny
platform.
A
drug-component-target
diagram
was
constructed
Cytoscape
3.7.2
software,
protein–protein
interaction
established
via
STRING
visualized
software.
biological
functions
wereanalyzed
Gene
Ontology
Kyoto
Encyclopedia
Genes
Genomes
(KEGG)
pathway
enrichment
analysis
DAVID
KEGG
visualization
bubble
charts
generated
OmicShare
online
platform
explore
KOA.
main
signaling
pathways
investigated
analysis.
Finally,
AutoDockTools
software
used
docking
validation
key
molecules
drug
proteins
disease.
total
108
active
compounds
280
target
identified.
There
2816
disease-related
related
KOA,
among
which
99
targeted
treatment.
Key
included
β-sitosterol,
stigmasterol,
campesterol,
quercetin,
dioscin.
Core
consisted
STAT3,
ESR1,
EGFR,
JUN,
PTGS2.
mainly
involved
advanced
glycation
end
products
–
receptor
products,
estrogen,
HIF-1,
relaxin
signal
pathways.
Molecular
showed
strong
binding
affinity
between
core
proteins.
Docking
candidates
selected
based
oral
bioavailability
≥
30%,
drug-likeness
0.18,
degree
values
Cytoscape.
strategy
ensured
reliable
selection
high
relevance.
provides
comprehensive
treatment
regulating
cell
proliferation
alleviating
inflammation
its
multi-component,
multi-target,
multi-pathway
effects.
Язык: Английский
Current Status and Perspectives of Research on Polymer Hydrogels in the Treatment and Protection of Osteoarthritis
Macromolecular Bioscience,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 24, 2025
Abstract
Arthritis
is
a
degenerative
disease
characterized
by
chronic
cartilage
degeneration.
It
affects
hundreds
of
millions
people
worldwide
and
often
has
serious
consequences
such
as
joint
pain
swelling,
limited
mobility,
deformity.
However,
conventional
treatments
still
struggle
to
achieve
satisfactory
results.
Finding
more
effective
for
arthritis
remains
an
important
clinical
challenge.
As
hydrogels
have
unique
3D
spatial
mesh
structure,
significant
material
interaction
ability,
adjustable
mechanical
properties,
good
biodegradability,
they
can
provide
suitable
cellular
or
tissue
microenvironment,
their
potential
in
scaffolding
effect,
lubrication,
anti‐inflammatory
drug
delivery
expected
be
potent
therapeutic
approach
the
treatment
osteoarthritis.
In
this
review,
three
aspects
hydrogel
products
osteoarthritis
are
comprehensively
summarized
discussed,
namely,
selection
gel
design,
exploration
cross‐linking
mechanisms,
mechanisms
therapy
osteoarthritis,
focus
on
advantages
limitations
applications,
which
point
out
direction
development
strategy
innovative
field,
applied
research,
transformation.
Язык: Английский