Coordination Chemistry Reviews, Год журнала: 2025, Номер 535, С. 216664 - 216664
Опубликована: Март 30, 2025
Язык: Английский
Coordination Chemistry Reviews, Год журнала: 2025, Номер 535, С. 216664 - 216664
Опубликована: Март 30, 2025
Язык: Английский
International Journal of Nanomedicine, Год журнала: 2025, Номер Volume 20, С. 1367 - 1382
Опубликована: Фев. 1, 2025
Abstract: Breast cancer remains a significant therapeutic challenge, with the immune microenvironment playing crucial role in its progression and treatment response. This review investigates potential of nanoparticles to modulate breast therapy. Initially, we discuss composition influence on cancer, followed by current strategies targeting these components. We then provide for cells such as macrophages, dendritic cells, T-cells. The enhancing checkpoint blockade (ICB) their application vaccines is also examined. Additionally, explore synergistic effects combining conventional therapies. addresses challenges clinical translation, focusing safety, biocompatibility, toxicity. Finally, outline future research directions advancements nanoparticle-based immunotherapy, emphasizing transformative impact treatment. Keywords: nanoparticle,
Язык: Английский
Процитировано
0ACS Applied Materials & Interfaces, Год журнала: 2025, Номер unknown
Опубликована: Фев. 13, 2025
Single-atom nanozymes are highly effective in the preparation of tumor vaccines (TV) due to their superior peroxidase (POD) activity and excellent biocompatibility. However, immunosuppressive environment within tumors can diminish efficacy these vaccines. Cold exposure (CE) therapy, a noninvasive straightforward antitumor method, not only suppresses metabolism but also ameliorates milieu. In this study, we developed personalized TV using copper single-atom nanozyme (Cu SAZ) enhanced long-term by introducing CE. We initially synthesized Cu SAZ via high-temperature carbonization, which demonstrated robust POD photothermal characteristics. Upon 808 nm laser irradiation, generated reactive oxygen species (ROS) heat, inducing immunogenic cell death 4T1 breast cancer cells or CT26 colon facilitating production. our vivo prevention treatment model, noted that CE significantly boosted TV. The primary mechanism involves CE's ability lower ratio myeloid-derived suppressor (MDSCs), decrease glucose cells, increase proportions CD8+ T memory cells. Collectively, findings offer promising avenues for designing innovative systems.
Язык: Английский
Процитировано
0Coordination Chemistry Reviews, Год журнала: 2025, Номер 535, С. 216664 - 216664
Опубликована: Март 30, 2025
Язык: Английский
Процитировано
0