Chondrocalcin: Insights into Its Regulation and Multi-Function in Cartilage and Bone
Differentiation,
Год журнала:
2025,
Номер
unknown, С. 100861 - 100861
Опубликована: Март 1, 2025
Язык: Английский
Hepatorenal protective effects of essential oils against chemical overexposure induced oxidative damage
Frontiers in Pharmacology,
Год журнала:
2025,
Номер
16
Опубликована: Апрель 16, 2025
Chemical
overexposure
is
a
significant
concern
in
both
environmental
and
occupational
settings,
often
leading
to
oxidative
stress
subsequent
cellular
damage.
The
review
covers
the
induced
by
chemical
substances
such
as
pesticides
(including
pyrethroid,
deltamethrin,
β-cyfluthrin,
malathion,
triflumuron,
methomyl,
diquat,
cypermethrin,
thiamethoxam,
profenofos),
medications
(acetaminophen),
nanoparticles
zinc
oxide,
iron,
silver,
titanium
dioxide),
heavy
metals
cadmium,
vanadium),
some
organic
chemicals
diethylnitrosamine
benzo(a)pyrene).
Focusing
on
preclinical
evidence
from
animal
models
cell-based
studies,
essential
oils
have
been
shown
significantly
enhance
antioxidative
enzyme
activities,
including
superoxide
dismutase,
catalase,
glutathione
peroxidase,
while
also
increasing
levels
of
non-enzymatic
antioxidants
uric
acid.
Additionally,
contribute
restoration
biochemical
parameters,
creatinine,
acid,
urea
levels,
mitigating
damage
reducing
cell
membrane
injury,
apoptosis,
histopathological
alterations.
this
evaluates
protective
benefits
against
models.
underlying
mechanism
involved
alleviating
hepatorenal
This
underscores
considerable
promise
candidates
for
medicinal
applications
functional
foods
or
medicines,
particularly
preventing
various
overexposure.
Язык: Английский
Recent Advances in the ESIPT-Based Drug Delivery Systems for Targeted Diseases Treatment
Dyes and Pigments,
Год журнала:
2025,
Номер
240, С. 112863 - 112863
Опубликована: Апрель 28, 2025
Язык: Английский
From molecular mechanisms to clinical translation: Silk fibroin-based biomaterials for next-generation wound healing
International Journal of Biological Macromolecules,
Год журнала:
2025,
Номер
313, С. 144266 - 144266
Опубликована: Май 15, 2025
Язык: Английский
Chitosan-Based Nanoparticles Targeted Delivery System: In Treatment Approach for Dyslipidemia
International Journal of Nanomedicine,
Год журнала:
2025,
Номер
Volume 20, С. 6611 - 6636
Опубликована: Май 1, 2025
Hyperlipidemia,
characterized
by
abnormally
high
lipid
levels
in
the
bloodstream,
is
a
significant
risk
factor
for
cardiovascular
diseases.
Conventional
treatments
have
limitations
efficacy
and
may
lead
to
side
effects.
Nanotechnology
offers
unique
advantages
drug
delivery,
including
improved
stability,
prolonged
circulation
time,
enhanced
tissue
targeting.
Using
nanoparticles
as
carriers,
therapeutic
agents
can
be
precisely
delivered
target
site,
such
liver
or
arterial
walls,
where
metabolism
occurs.
Chitosan
represent
an
advanced
approach
engineered
with
precision
atherosclerotic
plaques.
They
dual
functionalities,
serving
diagnostic
purposes
managing
atherosclerosis.
Targeting
strategies
involve
coating
ligands
antibodies
that
recognize
specific
receptors
overexpressed
hyperlipidemic
conditions.
This
selective
uptake
maximizes
effect
while
minimizing
off-target
effects,
making
it
promising
alternative
traditional
treatments.
The
review
provides
overview
of
recent
research
developments
dyslipidemia
based
on
molecular
pathway
dyslipidemia,
focusing
Chitosan-based
delivery
systems
allow
controlled
release,
targeting,
enhancing
patient
compliance.
Язык: Английский