Chitosan-Based Nanoparticles Targeted Delivery System: In Treatment Approach for Dyslipidemia DOI Creative Commons
Yedi Herdiana, Jutti Levita,

Supat Jiranusornkul

и другие.

International Journal of Nanomedicine, Год журнала: 2025, Номер Volume 20, С. 6611 - 6636

Опубликована: Май 1, 2025

Hyperlipidemia, characterized by abnormally high lipid levels in the bloodstream, is a significant risk factor for cardiovascular diseases. Conventional treatments have limitations efficacy and may lead to side effects. Nanotechnology offers unique advantages drug delivery, including improved stability, prolonged circulation time, enhanced tissue targeting. Using nanoparticles as carriers, therapeutic agents can be precisely delivered target site, such liver or arterial walls, where metabolism occurs. Chitosan represent an advanced approach engineered with precision atherosclerotic plaques. They dual functionalities, serving diagnostic purposes managing atherosclerosis. Targeting strategies involve coating ligands antibodies that recognize specific receptors overexpressed hyperlipidemic conditions. This selective uptake maximizes effect while minimizing off-target effects, making it promising alternative traditional treatments. The review provides overview of recent research developments dyslipidemia based on molecular pathway dyslipidemia, focusing Chitosan-based delivery systems allow controlled release, targeting, enhancing patient compliance.

Язык: Английский

Chondrocalcin: Insights into Its Regulation and Multi-Function in Cartilage and Bone DOI

Wensha Zhu,

Zilong Zhao,

Weigang Yuwen

и другие.

Differentiation, Год журнала: 2025, Номер unknown, С. 100861 - 100861

Опубликована: Март 1, 2025

Язык: Английский

Процитировано

0

Hepatorenal protective effects of essential oils against chemical overexposure induced oxidative damage DOI Creative Commons
Faming Jiang, Huang Xiao-yan,

X Chen

и другие.

Frontiers in Pharmacology, Год журнала: 2025, Номер 16

Опубликована: Апрель 16, 2025

Chemical overexposure is a significant concern in both environmental and occupational settings, often leading to oxidative stress subsequent cellular damage. The review covers the induced by chemical substances such as pesticides (including pyrethroid, deltamethrin, β-cyfluthrin, malathion, triflumuron, methomyl, diquat, cypermethrin, thiamethoxam, profenofos), medications (acetaminophen), nanoparticles zinc oxide, iron, silver, titanium dioxide), heavy metals cadmium, vanadium), some organic chemicals diethylnitrosamine benzo(a)pyrene). Focusing on preclinical evidence from animal models cell-based studies, essential oils have been shown significantly enhance antioxidative enzyme activities, including superoxide dismutase, catalase, glutathione peroxidase, while also increasing levels of non-enzymatic antioxidants uric acid. Additionally, contribute restoration biochemical parameters, creatinine, acid, urea levels, mitigating damage reducing cell membrane injury, apoptosis, histopathological alterations. this evaluates protective benefits against models. underlying mechanism involved alleviating hepatorenal This underscores considerable promise candidates for medicinal applications functional foods or medicines, particularly preventing various overexposure.

Язык: Английский

Процитировано

0

Recent Advances in the ESIPT-Based Drug Delivery Systems for Targeted Diseases Treatment DOI
Hossein Roohi,

Mina Rouhi

Dyes and Pigments, Год журнала: 2025, Номер 240, С. 112863 - 112863

Опубликована: Апрель 28, 2025

Язык: Английский

Процитировано

0

From molecular mechanisms to clinical translation: Silk fibroin-based biomaterials for next-generation wound healing DOI
Bo Liu, Li Yang,

Han Chen

и другие.

International Journal of Biological Macromolecules, Год журнала: 2025, Номер 313, С. 144266 - 144266

Опубликована: Май 15, 2025

Язык: Английский

Процитировано

0

Chitosan-Based Nanoparticles Targeted Delivery System: In Treatment Approach for Dyslipidemia DOI Creative Commons
Yedi Herdiana, Jutti Levita,

Supat Jiranusornkul

и другие.

International Journal of Nanomedicine, Год журнала: 2025, Номер Volume 20, С. 6611 - 6636

Опубликована: Май 1, 2025

Hyperlipidemia, characterized by abnormally high lipid levels in the bloodstream, is a significant risk factor for cardiovascular diseases. Conventional treatments have limitations efficacy and may lead to side effects. Nanotechnology offers unique advantages drug delivery, including improved stability, prolonged circulation time, enhanced tissue targeting. Using nanoparticles as carriers, therapeutic agents can be precisely delivered target site, such liver or arterial walls, where metabolism occurs. Chitosan represent an advanced approach engineered with precision atherosclerotic plaques. They dual functionalities, serving diagnostic purposes managing atherosclerosis. Targeting strategies involve coating ligands antibodies that recognize specific receptors overexpressed hyperlipidemic conditions. This selective uptake maximizes effect while minimizing off-target effects, making it promising alternative traditional treatments. The review provides overview of recent research developments dyslipidemia based on molecular pathway dyslipidemia, focusing Chitosan-based delivery systems allow controlled release, targeting, enhancing patient compliance.

Язык: Английский

Процитировано

0