Self-Reporting Ratiometric AIEgen-Peptide Nanoprobes for Activatable Chemotherapy and Noninvasive Imaging of Therapeutic Outcomes DOI

Shicheng Pei,

Z. L. Liu,

Qishu Jiao

и другие.

Journal of Medicinal Chemistry, Год журнала: 2025, Номер unknown

Опубликована: Апрель 2, 2025

Efficacious chemotherapy and real-time therapeutic monitoring remain major challenges in cancer treatment. Traditional systems often lack tumor specificity, limiting efficacy, hindering therapy optimization. Moreover, the absence of can lead to missed opportunities increased risks side effects. Herein, we designed a self-reporting ratiometric AIEgen-peptide nanoprobe (TPE-1(Hyd-DOX)-DEVD) for activatable noninvasive imaging outcomes. When doxorubicin (DOX) is selectively activated acidic microenvironment, ensuing caspase-3 cascade triggers morphological transformation that amplifies TPE fluorescence. This enhancement allows TPE/DOX fluorescence ratio serve as an indicator DOX activation providing feedback. Both vitro vivo studies demonstrated TPE-1(Hyd-DOX)-DEVD exhibited impressive suppression efficacy excellent biocompatibility. study highlights strong potential this valuable tool theranostics, offering hope more effective personalized treatment strategies.

Язык: Английский

Self-Reporting Ratiometric AIEgen-Peptide Nanoprobes for Activatable Chemotherapy and Noninvasive Imaging of Therapeutic Outcomes DOI

Shicheng Pei,

Z. L. Liu,

Qishu Jiao

и другие.

Journal of Medicinal Chemistry, Год журнала: 2025, Номер unknown

Опубликована: Апрель 2, 2025

Efficacious chemotherapy and real-time therapeutic monitoring remain major challenges in cancer treatment. Traditional systems often lack tumor specificity, limiting efficacy, hindering therapy optimization. Moreover, the absence of can lead to missed opportunities increased risks side effects. Herein, we designed a self-reporting ratiometric AIEgen-peptide nanoprobe (TPE-1(Hyd-DOX)-DEVD) for activatable noninvasive imaging outcomes. When doxorubicin (DOX) is selectively activated acidic microenvironment, ensuing caspase-3 cascade triggers morphological transformation that amplifies TPE fluorescence. This enhancement allows TPE/DOX fluorescence ratio serve as an indicator DOX activation providing feedback. Both vitro vivo studies demonstrated TPE-1(Hyd-DOX)-DEVD exhibited impressive suppression efficacy excellent biocompatibility. study highlights strong potential this valuable tool theranostics, offering hope more effective personalized treatment strategies.

Язык: Английский

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