Nanoparticle-based antifungal therapies innovations mechanisms and future prospects

PeerJ, Год журнала: 2025, Номер 13, С. e19199 - e19199

Опубликована: Апрель 8, 2025

Fungal infections present an increasing global health challenge, with a substantial annual mortality rate of 1.6 million deaths each year in certain situations. The emergence antifungal resistance has further complicated treatment strategies, underscoring the urgent need for novel therapeutic approaches. This review explores recent advances nanoparticle-based therapies targeting fungal infections, emphasizing their unique potential to enhance drug solubility, bioavailability, and targeted delivery. Nanoparticles offer ability penetrate biological barriers, improve stability, act as direct agents by disrupting cell walls generating reactive oxygen species. Despite promising applications, challenges such toxicity, scalability production, controlled release remain. Future research should focus on optimizing nanoparticle properties, evaluating long-term safety profiles, developing environmentally sustainable synthesis methods, exploring synergistic approaches existing drugs. Nanotechnology offers transformative opportunity management diseases, paving way more effective treatments.

Язык: Английский

Influence of non-degradable and degradable microplastics on the bioavailability of per- and polyfluoroalkyl substance in mice: Mechanism exploration

The Science of The Total Environment, Год журнала: 2025, Номер 977, С. 179381 - 179381

Опубликована: Апрель 14, 2025

Язык: Английский

Oral Exposure to Pla Microplastics Induces Time-Dependent Nanotoxicity Via the Gut-Liver Axis

Опубликована: Янв. 1, 2025

Язык: Английский