Astragalus Polysaccharide Hydrogels with Drug-Carrying Super Self-Assembly from Natural Herbs Promote Wound Healing DOI

Mingyuan Zhao,

Jiawei Xiang,

Yuan Meng

и другие.

ACS Nano, Год журнала: 2025, Номер unknown

Опубликована: Июнь 3, 2025

The regulation of the immune microenvironment is a key component wound healing, where suitable dressings with skin immunoreactivity can favorably affect process and promote repairing progress. Therefore, we developed an injectable photo-cross-linkable composite hydrogel─oxidized astragalus polysaccharide carboxymethyl chitosan/sodium methacrylated alginate magnesium ions hydrogel (OAPS-CMC/SAMA-Mg2+, OCS) loaded curcumin (Cur)-encapsulated Achyranthes bidentata supramolecular self-assemblies (NX SSA) (NX@Cur)─termed OCS/NX@Cur to synergistically accelerate repair. polysaccharide-dominated matrix provided superior anti-inflammatory ability. Meanwhile, NX@Cur strong angiogenesis accelerated collagen deposition. In cellular experiments rat model total defects, exhibited anti-inflammatory, antioxidant, angiogenic capabilities. These properties modulated inflammatory environment wound, thereby promoting formation granulation tissue neovascularization accelerating deposition re-epithelialization. conclusion, showed excellent repair capabilities, providing potential therapeutic option for combination super self-assembly natural hydrogels

Язык: Английский

A multifaceted microenvironment nanonanoregulator for targeted ovarian cancer therapy DOI Creative Commons
Yizheng Zu, Min Li, R. Li

и другие.

Frontiers in Pharmacology, Год журнала: 2025, Номер 16

Опубликована: Март 27, 2025

The treatment of ovarian cancer is hindered by its insidious onset and rapid progression. Exosomes (EXOs) present a promising therapeutic strategy for modulating the tumor microenvironment. However, concerns regarding biosafety animal-derived EXOs pose significant challenges to development innovative formulations. In this study, we propose universal engineer plant-derived as microenvironment nanoregulators targeted therapy. derived from ginger were purified, loaded with natural bioactive compound curcumin (Cur) high encapsulation efficiency, functionalized tumor-targeting aptamer. Upon intravenous administration, resulting multifaceted nanoregulator, termed AGE@Cur, effectively accumulates at site exerts tumor-suppressive effect through remodeling This novel platform not only addresses limitations but also paves way regulators in clinical applications.

Язык: Английский

Процитировано

0
Astragalus Polysaccharide Hydrogels with Drug-Carrying Super Self-Assembly from Natural Herbs Promote Wound Healing DOI

Mingyuan Zhao,

Jiawei Xiang,

Yuan Meng

и другие.

ACS Nano, Год журнала: 2025, Номер unknown

Опубликована: Июнь 3, 2025

The regulation of the immune microenvironment is a key component wound healing, where suitable dressings with skin immunoreactivity can favorably affect process and promote repairing progress. Therefore, we developed an injectable photo-cross-linkable composite hydrogel─oxidized astragalus polysaccharide carboxymethyl chitosan/sodium methacrylated alginate magnesium ions hydrogel (OAPS-CMC/SAMA-Mg2+, OCS) loaded curcumin (Cur)-encapsulated Achyranthes bidentata supramolecular self-assemblies (NX SSA) (NX@Cur)─termed OCS/NX@Cur to synergistically accelerate repair. polysaccharide-dominated matrix provided superior anti-inflammatory ability. Meanwhile, NX@Cur strong angiogenesis accelerated collagen deposition. In cellular experiments rat model total defects, exhibited anti-inflammatory, antioxidant, angiogenic capabilities. These properties modulated inflammatory environment wound, thereby promoting formation granulation tissue neovascularization accelerating deposition re-epithelialization. conclusion, showed excellent repair capabilities, providing potential therapeutic option for combination super self-assembly natural hydrogels

Язык: Английский

Процитировано

0