Organosilanes and their magnetic nanoparticles as naked eye red emissive sensors for Ag⁺ ions and potent anti-oxidants

New Journal of Chemistry, Год журнала: 2021, Номер 45(12), С. 5517 - 5525

Опубликована: Янв. 1, 2021

This work involves the synthesis of organosilanes as colorimetric sensors for detection Ag⁺ ions, cytotoxicity studies and antioxidant activity.

Язык: Английский

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Novel ciprofloxacin and norfloxacin-tetrazole hybrids as potential antibacterial and antiviral agents: Targeting S. aureus topoisomerase and SARS-CoV-2-MPro

Journal of Molecular Structure, Год журнала: 2022, Номер 1274, С. 134507 - 134507

Опубликована: Ноя. 7, 2022

Язык: Английский

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Microwave accelerated green approach for tailored 1,2,3–triazoles via CuAAC

Sustainable Chemistry and Pharmacy, Год журнала: 2022, Номер 30, С. 100824 - 100824

Опубликована: Сен. 30, 2022

Язык: Английский

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Pharmacological Significance of 1,2,3-Triazoles

Advances in chemical and materials engineering book series, Год журнала: 2025, Номер unknown, С. 155 - 202

Опубликована: Янв. 3, 2025

Click chemistry is not a single specific reaction, but was meant to mimic nature, which also generates substances by joining small modular units. The 1,3-dipolar azide, alkyne cycloaddition (CuAAC) reaction catalyzed copper, as nearly quantitative and easy execute has emerged the leading example of “click chemistry”. Given importance triazole scaffold in medicinal chemistry, its synthesis attracted attention drug discovery development community. This book chapter will summarizes major synthetic methods currently used for preparation pharmacological significance such antifungal, antibacterial, antitubercular, anticancer, anti-inflammatory, antioxidant many more properties discussed. Furthermore, this comprise literature from 2020 till date

Язык: Английский

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Analysing the effect caused by increasing the molecular volume in M1-AChR receptor agonists and antagonists: a structural and computational study

RSC Advances, Год журнала: 2024, Номер 14(13), С. 8615 - 8640

Опубликована: Янв. 1, 2024

M1 muscarinic acetylcholine receptor (M1-AChR), a member of the G protein-coupled receptors (GPCR) family, plays crucial role in learning and memory, making it an important drug target for Alzheimer's disease (AD) schizophrenia. M1-AChR activation deactivation have shown modifying effects AD PD preclinical models, respectively. However, understanding pharmacology associated with or is complex, because low selectivity among subtypes, hampering their therapeutic applications. In this regard, we constructed two quantitative structure-activity relationship (QSAR) one agonists (total partial), other antagonists. The binding mode 59 structurally different compounds, including antagonists experimental affinity values (pKi), were analyzed employing computational molecular docking over structures M1-AChR. Furthermore, considered interaction energy (Einter), number rotatable bonds (NRB), lipophilicity (ilogP) construction QSAR model (R2 = 89.64, QLMO2 78, Qext2 79.1). For 88.44, 82, 78.1) Einter, fraction sp3 carbons fCsp3, (MlogP). Our results suggest that ligand volume determinant to establish its biological activity (agonist antagonist), causing changes energy, determining

Язык: Английский

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Hormonal Treatment for Breast Carcinoma

Journal of Datta Meghe Institute of Medical Sciences University, Год журнала: 2025, Номер 20(1), С. 8 - 12

Опубликована: Янв. 1, 2025

Abstract Breast carcinoma (BCa) is the primary cause of death in women these common types estrogen-positive BCa. Endocrine treatment mainly focused on estrogen receptor-positive The concept ER-positive BCa a quickly evolving area. As result several clinical trials conducted over past 20 years Survival rates have been increased for patients with hormone-positive cancer at all stages. result, care physician will be more actively involved ongoing monitoring, treatment, and control issues linked to antihormonal therapy. purpose current research was highlight recent developments area therapy while also providing succinct summary about fundamental care.

Язык: Английский

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Synthesis of 1,2,3-triazole-thymol derivatives as potential antimicrobial agents

Heliyon, Год журнала: 2022, Номер 8(10), С. e10836 - e10836

Опубликована: Окт. 1, 2022

Thymol as a natural biological template can be modified chemically since the hydroxyl group makes it candidate for structural modification. Thus, this study incorporated triazole moiety on thymol and chlorination of to help improve its potency.

Язык: Английский

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Pharmacological Diversity of Triazole Scaffolds: A Review

Current Bioactive Compounds, Год журнала: 2022, Номер 18(10)

Опубликована: Март 8, 2022

Background: Heterocyclic compounds possess a wide variety of roles in most fields science, such as biochemistry, medicinal chemistry, veterinary products, agrochemicals, etc. Triazole, heterocycle compound, serves building block for various having multiple applications, mostly medicine. Triazole is five-membered ring containing that occur nature, found several microorganisms, fungi, and marine organisms. The triazole nucleus boon researchers with significant scope the long-term. derivatives pharmacological properties due to their ability exert non-covalent interactions, which can improve solubility bind bimolecular targets. Objective: We focused on structure-activity relationship possessing biological activities antibacterial, antifungal, anticonvulsant, antidiabetic, antimalarial, analgesic, anti-inflammatory, antioxidant, antidepressant, antitubercular, anticancer, Results: This study revealed significance certain substituents nuclei different activities. Conclusion: From this, we conclude will be lead further research drug discovery.

Язык: Английский

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Synthesis and Biological Activities of Some 1,2,4-Triazole Derivatives: A Review

Al Mustansiriyah Journal of Pharmaceutical Sciences, Год журнала: 2022, Номер 22(3), С. 65 - 81

Опубликована: Окт. 24, 2022

This review is about 1,2,4-triazoles include their synthesis; physio-chemical properties, SAR, reactions, derivatives. Finally, biological activities with a demonstrated showing different requirements to achieve activity

Язык: Английский

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Discovery of Octahydroisoindolone as a Scaffold for the Selective Inhibition of Chitinase B1 from Aspergillus fumigatus: In Silico Drug Design Studies

Molecules, Год журнала: 2021, Номер 26(24), С. 7606 - 7606

Опубликована: Дек. 15, 2021

Chitinases represent an alternative therapeutic target for opportunistic invasive mycosis since they are necessary fungal cell wall remodeling. This study presents the design of new chitinase inhibitors from a known hydrolysis intermediate. Firstly, bioinformatic analysis Aspergillus fumigatus B1 (AfChiB1) and chitotriosidase (CHIT1) by length conservation was done to obtain consensus sequences, molecular homology models fungi human chitinases were built determine their structural differences. We explored octahydroisoindolone scaffold as potential antifungal series means its electronic features. Therefore, we evaluated several synthesis-safe derivatives docking AfChiB1 interaction profile. Additionally, compounds with best profile (1-5) docked within CHIT1 catalytic site evaluate selectivity over AfChiB1. Furthermore, considered energy (MolDock score) lipophilic parameter (aLogP) selection candidates. Based on these descriptors, constructed mathematical model IC50 prediction our candidates (60-200 μM), using experimental As final step, ADME characteristics obtained all candidates, showing that 5 is designed hit, which possesses pharmacodynamic pharmacokinetic character.

Язык: Английский

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