Discovery of imidazopyridine derived oxadiazole-based thiourea derivatives as potential anti-diabetic agents: Synthesis, in vitro antioxidant screening and in silico molecular modeling approaches
Journal of Molecular Structure,
Год журнала:
2023,
Номер
1293, С. 136185 - 136185
Опубликована: Июль 21, 2023
Язык: Английский
Correlation between in vitro anti-urease activity and in silico molecular modeling approach of novel imidazopyridine–oxadiazole hybrids derivatives
Open Chemistry,
Год журнала:
2024,
Номер
22(1)
Опубликована: Янв. 1, 2024
Abstract
In
the
current
era,
a
potent
drug
is
still
needed
on
market
for
treatment
of
various
diseases
worldwide.
Researchers
mainly
focus
those
enzymes
that
cause
these
diseases.
One
major
caused
by
an
enzyme
called
urease,
which
increases
concentration
ammonia
in
body
upon
hydrolysis.
across
globe
have
keen
interest
to
synthesize
inhibitor
this
conversion.
From
perspective,
hybrid
analogs
imidazopyridine
and
oxadiazole
(
1–20
)
were
designed
efficiently
synthesized
followed
characterizing
them
through
varied
spectroscopic
methods
1
HNMR,
13
CNMR,
HREI-MS).
addition,
vitro
analyses
compounds
conducted
evaluate
their
anti-urease
potency.
There
was
significant
potential
most
analyzed,
but
15
,
16,
17
(IC
50
=
2.20
±
0.10
μM,
IC
2.50
2.30
2.10
respectively)
performed
exceptionally
well
comparison
with
thiourea
22.30
0.44
μM).
The
selected
candidates
further
investigated
under
molecular
docking
study
confirm
protein
ligand
interactions.
energy
gap
E
HOMO–LUMO
explored
via
density
functional
theory
studies.
Язык: Английский
Unveiling the chemistry of 1,3,4‐oxadiazoles and thiadiazols: A comprehensive review
Archiv der Pharmazie,
Год журнала:
2023,
Номер
357(1)
Опубликована: Окт. 15, 2023
Abstract
Oxadiazoles
and
thiadiazoles
are
malleable
heterocycles
that
have
recently
generated
major
interest
in
the
field
of
medicinal
chemistry.
Compounds
based
on
these
moieties
versatile
biological
applications
such
as
anticonvulsant,
anticancer,
antidiabetic,
antioxidant
agents.
Due
to
nature
stability
oxadiazole
thiadiazole
nucleus,
chemists
changed
structural
elements
ring
numerous
ways.
These
compounds
shown
significant
anticonvulsant
effects,
demonstrating
their
potential
management
epileptic
disorders.
In
this
review,
we
covered
pathways
silico
targeted
proteins
derivatives
for
treating
various
The
data
compiled
article
will
be
helpful
researchers,
research
scientists,
who
work
drug
discovery
development.
Язык: Английский
Construction of novel Mg Fe2O4/MgO composite: A high performer Photocatalyst for the cyclization of 1,3,4-oxadiazoles under Sunlight Irradiation
Journal of the Indian Chemical Society,
Год журнала:
2025,
Номер
unknown, С. 101688 - 101688
Опубликована: Март 1, 2025
Язык: Английский
Identification of novel oxadiazole-based benzothiazole derivatives as potent inhibitors of α-glucosidase and urease: Synthesis, in vitro bio-evaluation and their in silico molecular docking study
Journal of Saudi Chemical Society,
Год журнала:
2023,
Номер
27(4), С. 101682 - 101682
Опубликована: Июнь 26, 2023
This
research
work
represents
a
synthetic
approach
for
the
development
of
hybrids
derivatives
oxadiazole-based
benzothiazole
(1-17)
and
diversity
in
was
achieved
using
variety
aryl
ring
S-substituted
to
see
effect
on
biological
activities.
All
synthesized
were
evaluated
their
vitro
α-glucosidase
urease
inhibitory
potential.
The
inhibition
profile
new
moderate
good
potential
with
IC50
values
ranging
from
4.60
±
1.20
µM
48.40
7.70
(α-glucosidase)
8.90
2.80
57.30
(urease)
respectively.
results
compared
standard
acarbose
(38.60
4.50
µM)
thiourea
(58.70
6.80
drugs
Among
series,
analogs
1
having
4.60±
(α-glucosidase),
2
5.60
1.60
10.90
2.10(urease)
found
be
significantly
active
against
targeted
enzymes.
structure
all
newly
synthetics
scaffolds
confirmed
by
different
types
spectroscopic
techniques
such
as
HREI-MS,
1H-
13C-
NMR
spectroscopy.
molecular
docking
studies
showed
correlations
experimental
findings.
binding
modes
compounds
interactions
site
residues
revealed
them
possible
anti-diabetics
anti-urease
leads.
degree
activity
displayed
novel
innovative
structural
moieties
make
these
leads
promising
candidates
agents.
Язык: Английский
FeCl3-Catalyzed Synthesis of Symmetrical Pyridines from Ketoxime Acetates Using DMFDMA as an Effective C1 Synthon
Polycyclic aromatic compounds,
Год журнала:
2023,
Номер
44(7), С. 4455 - 4466
Опубликована: Сен. 7, 2023
AbstractAn
efficient
and
facile
strategy
has
been
developed
for
the
synthesis
of
symmetrical
pyridines
in
good
to
excellent
yields
from
ketoxime
acetates
DMFDMA
presence
FeCl3
at
120
°C
6
h
under
argon
atmosphere.
In
this
protocol,
acts
as
an
effective
C1
synthon.
The
use
inexpensive
catalysts,
no
need
additional
ligands
additives,
functional
group
tolerance
are
perks
protocol.Keywords:
Symmetrical
pyridinesDMFDMAoximeacetatesFeCl3C1
synthon
AcknowledgmentsThe
authors
thank
DST
(Department
Science
&
Technology),
New
Delhi
funding
through
project
EEQ/2021/000168.Disclosure
statementNo
potential
conflict
interest
was
reported
by
authors.
Язык: Английский