Abstract
N‐
glycosides
are
produced
when
an
aglycone
is
connected,
for
example,
using
a
glycosylation
reaction,
to
the
sugar
moiety
via
linkage
of
C−N
bond
at
anomeric
carbon.
N
‐glycosides
obtained
from
different
precursors,
including
glucals,
1‐azido
glycosides,
glycosyl
azide,
isothiocyanate,
2‐deoxy‐2‐iodo‐
‐glycoside,
glycosyl‐1
H
‐1,2,3‐triazol,
and
2‐nitroglucal.
The
biological
relevance
‐glycopyranosides
has
drowned
attracted
attention
several
researchers.
scope
this
review
covers
literature
2010
2022.
Recent
advances
focused
on
natural
occurrence,
synthesis,
mechanism,
pharmacological
applications
discussed.
Molecules,
Год журнала:
2022,
Номер
27(24), С. 8723 - 8723
Опубликована: Дек. 9, 2022
A
series
of
hydrazine-1-carbothioamides
derivatives
(3a-3j)
were
synthesized
and
analyzed
for
inhibitory
potential
towards
bovine
carbonic
anhydrase
II
(b-CA
II)
15-lipoxygenase
(15-LOX).
Interestingly,
four
derivatives,
3b,
3d,
3g,
3j,
found
to
be
selective
inhibitors
CA
II,
while
other
exhibited
15-LOX
inhibition.
In
silico
studies
the
most
potent
both
b-CA
carried
out
find
possible
binding
mode
compounds
in
their
active
site.
Furthermore,
MD
simulation
results
confirmed
that
these
ligands
are
stably
bound
two
targets,
energy
further
effects
3h
compound.
As
may
have
a
role
particular
diseases,
reported
great
relevance
future
applications
field
medicinal
chemistry.
Abstract
N‐
glycosides
are
produced
when
an
aglycone
is
connected,
for
example,
using
a
glycosylation
reaction,
to
the
sugar
moiety
via
linkage
of
C−N
bond
at
anomeric
carbon.
N
‐glycosides
obtained
from
different
precursors,
including
glucals,
1‐azido
glycosides,
glycosyl
azide,
isothiocyanate,
2‐deoxy‐2‐iodo‐
‐glycoside,
glycosyl‐1
H
‐1,2,3‐triazol,
and
2‐nitroglucal.
The
biological
relevance
‐glycopyranosides
has
drowned
attracted
attention
several
researchers.
scope
this
review
covers
literature
2010
2022.
Recent
advances
focused
on
natural
occurrence,
synthesis,
mechanism,
pharmacological
applications
discussed.
