4,6‐Dihydroxysalicylic Acid‐Catalyzed Oxidative Olefination of Methyl N‐Heteroarenes with Benzyl Amines DOI
Chunping Dong, Yumei Wang, Shiyu Chen

и другие.

European Journal of Organic Chemistry, Год журнала: 2023, Номер 26(29)

Опубликована: Июль 7, 2023

Abstract Benzyl amines were deaminated for the olefination of methyl N ‐heteroarenes such as quinolines, benzothiazoles, and quinoxalines catalyzed by 4,6‐dihydroxysalicylic acid with only 1 mol % catalyst loading. A wide range ‐heteroaryl stilbenoids synthesized in yields 42 to 96 using oxygen (1 atm) sole oxidant. not behaves an organocatalyst oxidation benzyl imine intermediates, but also provides acidic reaction condition olefinations. Gram scale synthesis two pharmaceutically relevant conjugated olefins successful this methodology.

Язык: Английский

Novel route of neocuproine functionalization DOI
Ekaterina S. Spesivaya, Dzhamilya N. Konshina, Ф. А. Колоколов

и другие.

Russian Chemical Bulletin, Год журнала: 2025, Номер 74(1), С. 110 - 114

Опубликована: Янв. 1, 2025

Язык: Английский

Процитировано

0

Synthesis and antifungal activities of novel trifluoroethane derivatives with coumarin, indole and thiophene DOI Creative Commons

Bingyi Zhou,

Xinxin Yuan, Liangxin Fan

и другие.

Journal of Saudi Chemical Society, Год журнала: 2022, Номер 26(6), С. 101572 - 101572

Опубликована: Ноя. 1, 2022

A series of novel 1-(β-coumarinyl)-1-(β-indolyl)-1-(α-thiophenyl)trifluoroethane derivatives 5aaa-5hdb were prepared by one-pot reaction from 3-(trifluoroacetyl)coumarin with indole and α-substituted thiophene. Their structures confirmed 1H NMR, 13C 19F HRMS X-ray single crystal diffraction, their antifungal activities against F. moniliforme, graminearum, oxysporum, R. solani P. nicotianae evaluated. The title compounds displayed significant to moderate in vitro activity when compared the standard drug triadimefon. Among synthesized compounds, compound 5bfa showed highest inhibitor rate 83.5 % at 0.500 mg/mL solani, while 5ada 73.3 graminearum.

Язык: Английский

Процитировано

14

Catalyst- and solvent-free coupling of 2-methyl quinazolinones and 3-(trifluoroacetyl)coumarins: An environmentally benign access of quinazolinone derivatives DOI Creative Commons

Xiaodan Chang,

Liangxin Fan, Lijun Shi

и другие.

Journal of Saudi Chemical Society, Год журнала: 2023, Номер 27(2), С. 101621 - 101621

Опубликована: Фев. 25, 2023

An environmentally benign highly atom-economic protocol for the construction of CC bond has been developed under catalyst- and solvent-free conditions. This involves efficient coupling 2-methyl quinazolinones with 3-(trifluoroacetyl)coumarins access quinazolinone derivatives in excellent yields (up to 90 %). The crystal structure compound 3di was investigated by X-ray diffraction analysis. biological activities, such as vitro antifungal activity against Fusarium graminearum, moniliforme, oxysporum, Phytophthora parasitica var nicotianae, Rhizoctonia solani Kuhn, were investigated. bioassay results indicated that most target products exhibited promising fungicidal 3 cl 95 % R. solani, an EC50 value 10.6 μg/mL.

Язык: Английский

Процитировано

6

Catalyst-Free Synthesis of Novel α-Trifluoromethylated Tertiary Alcohols Bearing Azaarenes as Potential Antifungal Agents DOI
Nan Yang, Zhuang Wu, Mingxin Wang

и другие.

Journal of Molecular Structure, Год журнала: 2024, Номер unknown, С. 140042 - 140042

Опубликована: Сен. 1, 2024

Язык: Английский

Процитировано

1

4,6‐Dihydroxysalicylic Acid‐Catalyzed Oxidative Olefination of Methyl N‐Heteroarenes with Benzyl Amines DOI
Chunping Dong, Yumei Wang, Shiyu Chen

и другие.

European Journal of Organic Chemistry, Год журнала: 2023, Номер 26(29)

Опубликована: Июль 7, 2023

Abstract Benzyl amines were deaminated for the olefination of methyl N ‐heteroarenes such as quinolines, benzothiazoles, and quinoxalines catalyzed by 4,6‐dihydroxysalicylic acid with only 1 mol % catalyst loading. A wide range ‐heteroaryl stilbenoids synthesized in yields 42 to 96 using oxygen (1 atm) sole oxidant. not behaves an organocatalyst oxidation benzyl imine intermediates, but also provides acidic reaction condition olefinations. Gram scale synthesis two pharmaceutically relevant conjugated olefins successful this methodology.

Язык: Английский

Процитировано

3