Novel route of neocuproine functionalization
Russian Chemical Bulletin,
Год журнала:
2025,
Номер
74(1), С. 110 - 114
Опубликована: Янв. 1, 2025
Язык: Английский
Synthesis and antifungal activities of novel trifluoroethane derivatives with coumarin, indole and thiophene
Journal of Saudi Chemical Society,
Год журнала:
2022,
Номер
26(6), С. 101572 - 101572
Опубликована: Ноя. 1, 2022
A
series
of
novel
1-(β-coumarinyl)-1-(β-indolyl)-1-(α-thiophenyl)trifluoroethane
derivatives
5aaa-5hdb
were
prepared
by
one-pot
reaction
from
3-(trifluoroacetyl)coumarin
with
indole
and
α-substituted
thiophene.
Their
structures
confirmed
1H
NMR,
13C
19F
HRMS
X-ray
single
crystal
diffraction,
their
antifungal
activities
against
F.
moniliforme,
graminearum,
oxysporum,
R.
solani
P.
nicotianae
evaluated.
The
title
compounds
displayed
significant
to
moderate
in
vitro
activity
when
compared
the
standard
drug
triadimefon.
Among
synthesized
compounds,
compound
5bfa
showed
highest
inhibitor
rate
83.5
%
at
0.500
mg/mL
solani,
while
5ada
73.3
graminearum.
Язык: Английский
Catalyst- and solvent-free coupling of 2-methyl quinazolinones and 3-(trifluoroacetyl)coumarins: An environmentally benign access of quinazolinone derivatives
Journal of Saudi Chemical Society,
Год журнала:
2023,
Номер
27(2), С. 101621 - 101621
Опубликована: Фев. 25, 2023
An
environmentally
benign
highly
atom-economic
protocol
for
the
construction
of
CC
bond
has
been
developed
under
catalyst-
and
solvent-free
conditions.
This
involves
efficient
coupling
2-methyl
quinazolinones
with
3-(trifluoroacetyl)coumarins
access
quinazolinone
derivatives
in
excellent
yields
(up
to
90
%).
The
crystal
structure
compound
3di
was
investigated
by
X-ray
diffraction
analysis.
biological
activities,
such
as
vitro
antifungal
activity
against
Fusarium
graminearum,
moniliforme,
oxysporum,
Phytophthora
parasitica
var
nicotianae,
Rhizoctonia
solani
Kuhn,
were
investigated.
bioassay
results
indicated
that
most
target
products
exhibited
promising
fungicidal
3
cl
95
%
R.
solani,
an
EC50
value
10.6
μg/mL.
Язык: Английский
Catalyst-Free Synthesis of Novel α-Trifluoromethylated Tertiary Alcohols Bearing Azaarenes as Potential Antifungal Agents
Journal of Molecular Structure,
Год журнала:
2024,
Номер
unknown, С. 140042 - 140042
Опубликована: Сен. 1, 2024
Язык: Английский
4,6‐Dihydroxysalicylic Acid‐Catalyzed Oxidative Olefination of Methyl N‐Heteroarenes with Benzyl Amines
European Journal of Organic Chemistry,
Год журнала:
2023,
Номер
26(29)
Опубликована: Июль 7, 2023
Abstract
Benzyl
amines
were
deaminated
for
the
olefination
of
methyl
N
‐heteroarenes
such
as
quinolines,
benzothiazoles,
and
quinoxalines
catalyzed
by
4,6‐dihydroxysalicylic
acid
with
only
1
mol
%
catalyst
loading.
A
wide
range
‐heteroaryl
stilbenoids
synthesized
in
yields
42
to
96
using
oxygen
(1
atm)
sole
oxidant.
not
behaves
an
organocatalyst
oxidation
benzyl
imine
intermediates,
but
also
provides
acidic
reaction
condition
olefinations.
Gram
scale
synthesis
two
pharmaceutically
relevant
conjugated
olefins
successful
this
methodology.
Язык: Английский