Antimicrobial
resistance
(AMR)
has
emerged
as
a
significant
threat
to
human
health.
peptides
(AMPs)
have
proven
be
an
effective
strategy
against
antibiotic-resistant
bacteria,
given
their
capacity
swiftly
disrupt
microorganism
membranes
and
alter
cell
morphology.
However,
common
limitation
lies
in
the
inherent
toxicity
of
many
AMPs
vulnerability
protease
degradation
within
body.
Photothermal
therapy
(PTT)
stands
out
widely
utilized
approach
combating
bacterial
infections,
boasting
high
efficiency
non-invasive
benefits.
To
enhance
stability
antibacterial
efficacy
AMPs,
novel
involving
combination
PTT
been
proposed.
This
study
focuses
on
encapsulation
At10,
new
type
AMP
designed
by
our
group,
copper
sulfide
nanoparticles
(CuS
NPs)
zeolitic
imidazolate
framework-8
(ZIF-8)
form
At10/CuS@ZIF-8
nanoparticles.
The
encapsulated
CuS
NPs
exhibit
notable
photothermal
properties
upon
exposure
near-infrared
radiation.
induces
cleavage
ZIF-8,
facilitating
release
which
effectively
targets
exert
its
effects.
Bacteria
treated
with
light
radiation
exhibited
not
only
membrane
folding
intracellular
matrix
outflow
but
also
fracture.
synergistic
strategy,
integrating
unique
NPs,
pH
responsiveness
holds
promising
potential
for
widespread
application
treatment
infections.
RSC Applied Interfaces,
Год журнала:
2023,
Номер
1(1), С. 98 - 109
Опубликована: Ноя. 2, 2023
Silver(
i
)
and
copper(
ii
sulfonyldibenzoate
coordination
polymers
were
assembled
applied
as
bioactive
dopants
for
hybrid
biopolymer
films
with
remarkable
antibacterial
biofilm
inhibition
activity.
Biomimetics,
Год журнала:
2023,
Номер
9(1), С. 5 - 5
Опубликована: Дек. 23, 2023
The
3D
(three-dimensional)
micro–nanostructured
diatom
biosilica
obtained
from
cultivated
diatoms
was
used
as
a
support
to
immobilize
epitaxially
growing
AgCl-Ag
hybrid
nanoparticles
((Ag-AgCl)NPs)
for
the
synthesis
of
nanocomposites
with
antimicrobial
properties.
prepared
composites
that
contained
grown
(Ag-AgCl)NPs
were
investigated
in
terms
their
morphological
and
structural
characteristics,
elemental
mineral
composition,
crystalline
forms,
zeta
potential,
photoluminescence
properties
using
variety
instrumental
methods
including
SEM
(scanning
electron
microscopy),
TEM
(transmission
EDX
(energy-dispersive
X-ray
spectroscopy),
XRD
(X-ray
powder
diffraction),
zeta-potential
measurement,
spectroscopy.
content
(AgCl-Ag)NPs
amounted
4.6
mg/g
8.4
AgClNPs/AgNPs
ratios
percentage
86/14
51/49,
respectively.
Hybrid
evenly
dispersed
dominant
size
5
25
nm
composite
an
amount
silver.
average
7.5
nm;
also,
there
1–2
particles
20–40
nm.
potential
mechanism
studied.
MIC
(the
minimum
inhibitory
concentration
method)
approach
investigate
activity
against
microorganisms
Klebsiella
pneumoniae,
Escherichia
coli,
Staphylococcus
aureus.
containing
natural
showed
resistance
bacterial
strains
American
Type
Cultures
Collection
clinical
isolates
(diabetic
foot
infection
wound
isolates).
Multidrug-resistant
microbial
infections
represent
a
serious
hazard
to
human
health
and
have
proven
difficult
treat
in
clinical
settings.
In
this
study,
the
antibacterial
efficiency
of
graphene
quantum
dots
(GQDs)
derived
from
brewery
spent
grain
combination
with
zinc
oxide
(ZnO)
nanoparticles
against
methicillin-resistant
Staphylococcus
aureus
(MRSA)
isolated
wound
specimens
is
investigated
for
first
time.
The
crystallinity,
d-spacing,
π-π
stacking
nanomaterials
were
confirmed
by
X-ray
diffraction
analysis.
underlying
sheet-like
morphology
BSG-derived
reduced
(BrGO)
was
revealed
using
field
emission
scanning
electron
microscopy.
Raman
analysis
evidenced
an
ID/IG
ratio
0.95
BrGO,
which
indicates
higher
degree
structural
defects
disorder,
while
ZnO/GQDs
composite,
blue
shift
E2H
peak
indicated
decrease
particle
size
strain
crystal
structure.
high-resolution
transmission
microscopy
used
investigate
layered
structure
average
GQDs
(27
nm).
Interestingly,
composites
showed
better
activity
compared
individual
ZnO,
against,
Escherichia
coli,
aureus.
also
demonstrated
significant
disinfecting
MRSA
(ATCC
isolates
specimens).
Density
functional
theory
(DFT)
calculations
substantial
clustering
groups
at
edges
nanomaterial.
disinfection
mechanism
elucidated
time
DFT
calculations.
Cytotoxicity
experiments
3T3
mouse
embryo
fibroblasts
testified
that
are
not
toxic
mammalian
cells
concentrations
up
50
ug/mL.
Antimicrobial
resistance
(AMR)
has
emerged
as
a
significant
threat
to
human
health.
peptides
(AMPs)
have
proven
be
an
effective
strategy
against
antibiotic-resistant
bacteria,
given
their
capacity
swiftly
disrupt
microorganism
membranes
and
alter
cell
morphology.
However,
common
limitation
lies
in
the
inherent
toxicity
of
many
AMPs
vulnerability
protease
degradation
within
body.
Photothermal
therapy
(PTT)
stands
out
widely
utilized
approach
combating
bacterial
infections,
boasting
high
efficiency
non-invasive
benefits.
To
enhance
stability
antibacterial
efficacy
AMPs,
novel
involving
combination
PTT
been
proposed.
This
study
focuses
on
encapsulation
At10,
new
type
AMP
designed
by
our
group,
copper
sulfide
nanoparticles
(CuS
NPs)
zeolitic
imidazolate
framework-8
(ZIF-8)
form
At10/CuS@ZIF-8
nanoparticles.
The
encapsulated
CuS
NPs
exhibit
notable
photothermal
properties
upon
exposure
near-infrared
radiation.
induces
cleavage
ZIF-8,
facilitating
release
which
effectively
targets
exert
its
effects.
Bacteria
treated
with
light
radiation
exhibited
not
only
membrane
folding
intracellular
matrix
outflow
but
also
fracture.
synergistic
strategy,
integrating
unique
NPs,
pH
responsiveness
holds
promising
potential
for
widespread
application
treatment
infections.
