Enhanced Sensitivity Mach–Zehnder Interferometer-Based Tapered-in-Tapered Fiber-Optic Biosensor for the Immunoassay of C-Reactive Protein

Biosensors, Год журнала: 2025, Номер 15(2), С. 90 - 90

Опубликована: Фев. 6, 2025

A Mach–Zehnder interferometer-based tapered-in-tapered fiber-optic biosensor was introduced in this paper. By integrating a micro-tapered fiber into single tapered structure, the design enhances sensitivity, signal-to-noise ratio, and resolution capability, while reducing length of sensing fiber. Through simulation analysis, it found that significantly improved refractive index detection sensitivity by exciting stronger evanescent field effect. The experimental comparison between traditional showed 1.7-fold increase reaching 3266.78 nm/RIU within range 1.3326 to 1.3414. Furthermore, expand its application prospects biomedical field, glutaraldehyde cross-linking technology used immobilize C-reactive protein (CRP) antibodies on surface fiber, successfully creating biosensing platform for specific recognition CRP. results demonstrate novel can rapidly accurately detect CRP molecules at different concentrations with limit 0.278 μg/mL, exhibits good selectivity repeatability. This provides new insights development high-performance immunosensors shows broad potential immunology research early disease diagnosis.

Язык: Английский

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Synthesis of Bi2O3 Nanomaterials with Different Crystal Structures (α-, β- and γ-phase) Based on Calcined Bi2O2CO3 and Their Potential Applications in Photocatalysis and Acetone Gas Sensors

Sensors and Actuators B Chemical, Год журнала: 2025, Номер unknown, С. 137812 - 137812

Опубликована: Апрель 1, 2025

Язык: Английский

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Optical fiber sensing probe for detecting a carcinoembryonic antigen using a composite sensitive film of PAN nanofiber membrane and gold nanomembrane

Optics Express, Год журнала: 2024, Номер 32(11), С. 20024 - 20024

Опубликована: Май 7, 2024

An optical fiber sensing probe using a composite sensitive film of polyacrylonitrile (PAN) nanofiber membrane and gold nanomembrane is presented for the detection carcinoembryonic antigen (CEA), biomarker associated with colorectal cancer other diseases. The based on tilted Bragg grating (TFBG) surface plasmon resonance (SPR) functionalized PAN coating that selectively binds to CEA molecules. performance evaluated by measuring spectral shift TFBG resonances as function concentration in buffer. exhibits sensitivity 0.46 dB/(µg/ml), low limit 505.4 ng/mL buffer, good selectivity reproducibility. proposed offers simple, cost-effective, novel method can be potentially applied clinical diagnosis monitoring CEA-related

Язык: Английский

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Precise detection of trace level protein using MIP-MoS₂ nanocomposite functionalized PCF based interferometer

Optics Express, Год журнала: 2024, Номер 32(6), С. 10033 - 10033

Опубликована: Фев. 8, 2024

Fiber optic interferometry combined with recognizing elements has attracted intensive attention for the development of different biosensors due to its superior characteristic features. However, immobilization sensing alone is not capable low-concentration detection weak interaction evanescent field transducer. The utilization 2D materials high absorption potential and specific surface area can enhance intensity hence sensitivity sensor. Here, a biosensor been fabricated using an inline hetero fiber structure photonic crystal (PCF) single-mode (SMF) functionalized nanocomposite molybodenum di-sulfide (MoS 2 ) molecular imprinting polymer (MIP) detect trace levels bovine serum albumin (BSA). sensor showed wide dynamic range 2.34 × 10 7 pm/µg L -1 . It shows working over pH subfemtomolar limit. compact size, easy fabrication, stable structure, long range, this would open new path online remote applications.

Язык: Английский

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A critical review of electrochemical and optical Vitamin B6 sensing: evolution of biosensor platforms based on advanced nanosystems

Critical Reviews in Food Science and Nutrition, Год журнала: 2024, Номер unknown, С. 1 - 21

Опубликована: Авг. 8, 2024

Vitamin B6 (VB6) is a member of the water-soluble B vitamins which have vital performance in nervous system operating activities. VB6 highly demanded to maintain excellent skin and immune systems human body. furthermore, tremendously substantial functions some enzymes that participate metabolism proteins, amino acids, etc. The deficiency will eventuate anemic situations may lead permanent injuries brain. moreover, recent studies disclosed adequate body can decrease intensity illnesses such as diabetes, stress, etc., patients with COVID-19 infections. Thus, detection from real samples crucial control amount this vitamin biological fluids monitor pharmaceutical dosage quality. Various analytical approaches been employed for samples. Although biosensing sensing hold several obvious advantages simplicity, capability miniaturization, quick response time, other methods. Hence, through last decades, designing fabricating biosensors sufficient sensitivity selectivity investigated by many researchers order detect VB6. purpose review illustrate importance diverse electrochemical optical detection. Additionally, novel techniques based on electrochemical, optical, conventional methods considerably discussed, compared each other. Furthermore, comprehensive summary current limitations future challenges analysis are explained also create pathway subsequent expansions applications.

Язык: Английский

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Label-free detection of bovine serum albumin based on a microfiber biosensor with controllable optimized structure

Sensors and Actuators A Physical, Год журнала: 2024, Номер 375, С. 115543 - 115543

Опубликована: Июнь 5, 2024

Язык: Английский

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Ultrahigh-Sensitivity Detection of TNF-α Based on U-Shape Single Mode-Tapered Four Core-Single Mode Fiber Biosensor

IEEE Sensors Journal, Год журнала: 2024, Номер 24(20), С. 31735 - 31740

Опубликована: Сен. 9, 2024

Язык: Английский

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Post-Selection Design of Aptamers: Comparative Study of Affinity of the DNA Aptamers to Recombinant Extracellular Domain of Human Epidermal Growth Factor Receptors

Biochemistry (Moscow), Год журнала: 2024, Номер 89(12-13), С. 2183 - 2193

Опубликована: Дек. 1, 2024

Язык: Английский

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