Materials Today Bio,
Год журнала:
2024,
Номер
29, С. 101323 - 101323
Опубликована: Ноя. 8, 2024
Intervertebral
disc
degeneration
(IDD)
is
a
common
degenerative
disease
of
the
spine
that
has
significant
impact
on
both
society
and
human
health.
Many
studies
have
confirmed
there
close
relationship
between
IDD
senescence
apoptosis,
autophagy
can
combat
apoptosis
senescence.
Spatholobi
caulis
(SC)
an
herb
contains
various
active
compounds
are
effective
in
tissue
repair
regeneration,
but
it
not
been
explored
field
IDD.
In
this
study,
was
first
found
SC
boost
reduce
Nucleus
pulposus
cell
(NPCs).
However,
our
animal
revealed
limited
absorption
SC.
To
improve
bioavailability
efficacy
SC,
we
developed
hydrogel
incorporating
quaternary
ammonium
chitosan
(QCS)
oxidized
starch
(OST)
as
carriers
for
The
QCS-OST/SC
exhibits
excellent
compatibility
with
cells,
be
easily
injected,
release
durably.
At
cellular
level,
enhances
viability,
initiates
extracellular
matrix
(ECM),
inhibits
apoptosis.
injection
via
microneedles
(MNs)
into
discs
had
successfully
diminished
rats,
which
shows
broad
potential
treatment
Advances in Natural Sciences Nanoscience and Nanotechnology,
Год журнала:
2024,
Номер
15(4), С. 045004 - 045004
Опубликована: Сен. 30, 2024
Abstract
Copper
indium
disulfide
(CuInS
2
)
nanostructures
are
synthesized
by
wet
precipitation
and
sol–gel
techniques.
The
high-resolution
transmission
electron
microscopy
(HRTEM)
analysis
exhibits
nanorods
(NR)
nanocubes
(NC)
of
CuInS
resulting
from
methods,
respectively.
Their
characterizations
accomplished
UV–vis-NIR
spectroscopy,
dynamic
light
scattering
(DLS),
x-ray
diffraction
(XRD)
particle
size
is
obtained
HRTEM,
UV–vis-NIR,
DLS
analyses.
Average
crystallite
estimated
via
Scherrer’s
method
(graphical
analytical),
Monshi-Scherrer
method,
Williamson–Hall
relations
(uniform
deformation,
uniform
stress
deformation
energy-density
models),
size-strain
plot
Halder-Wagner
relation
using
XRD
profile
which
also
compared
with
as-obtained
size.
Moreover,
the
pattern
reflection
peaks
used
to
assess
more
accurately
energy
density,
lattice
stress,
microstrain
values.
results
affirm
NR
have
higher
(∼22
nm)
than
NC
(∼16
nm).
outcomes
demonstrate
outstanding
agreement
predicted
average
sizes
different
approaches.
Future Medicinal Chemistry,
Год журнала:
2024,
Номер
16(18), С. 1853 - 1863
Опубликована: Авг. 9, 2024
Derivatization
has
been
tremendously
utilized
in
the
field
of
drug
discovery
for
optimizing
pharmacological
properties
and
improving
safety,
efficacy
selectivity.
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(4), С. 2263 - 2263
Опубликована: Фев. 13, 2024
Organometallic
drug
development
is
still
in
its
early
stage,
but
recent
studies
show
that
organometallics
having
iron
as
the
central
atom
have
possibility
of
becoming
good
candidates
because
an
important
micro-nutrient,
and
it
compatible
with
many
biological
systems,
including
human
body.
Being
eco-friendly
Lewis
acid,
can
accept
lone
pair
electrons
from
imino(sp2)-nitrogen,
resultant
iron-imine
complexes
a
interacting
several
proteins
enzymes
humans.
Iron-imine
demonstrated
significant
potential
anticancer,
bactericidal,
fungicidal,
other
medicinal
activities
years.
This
article
systematically
discusses
major
synthetic
methods
pharmacological
potentials
vitro
activity
to
clinical
performance
2016
date.
In
nutshell,
this
manuscript
offers
simplistic
view
inorganic
chemistry:
for
instance,
presented
"eco-friendly
non-toxic"
metal
(as
opposed
platinum)
will
lead
non-toxic
pharmaceuticals.
The
abundant
literature
on
chelators
shows
complexes,
particularly
if
redox-active
cells,
be
quite
cytotoxic,
which
beneficial
future
targeted
therapies.
While
we
made
every
effort
include
all
related
papers,
any
omission
purely
unintentional.
Materials Today Bio,
Год журнала:
2024,
Номер
29, С. 101323 - 101323
Опубликована: Ноя. 8, 2024
Intervertebral
disc
degeneration
(IDD)
is
a
common
degenerative
disease
of
the
spine
that
has
significant
impact
on
both
society
and
human
health.
Many
studies
have
confirmed
there
close
relationship
between
IDD
senescence
apoptosis,
autophagy
can
combat
apoptosis
senescence.
Spatholobi
caulis
(SC)
an
herb
contains
various
active
compounds
are
effective
in
tissue
repair
regeneration,
but
it
not
been
explored
field
IDD.
In
this
study,
was
first
found
SC
boost
reduce
Nucleus
pulposus
cell
(NPCs).
However,
our
animal
revealed
limited
absorption
SC.
To
improve
bioavailability
efficacy
SC,
we
developed
hydrogel
incorporating
quaternary
ammonium
chitosan
(QCS)
oxidized
starch
(OST)
as
carriers
for
The
QCS-OST/SC
exhibits
excellent
compatibility
with
cells,
be
easily
injected,
release
durably.
At
cellular
level,
enhances
viability,
initiates
extracellular
matrix
(ECM),
inhibits
apoptosis.
injection
via
microneedles
(MNs)
into
discs
had
successfully
diminished
rats,
which
shows
broad
potential
treatment
