Allergo Journal, Год журнала: 2024, Номер 33(7), С. 16 - 21
Опубликована: Окт. 31, 2024
Trends in Endocrinology and Metabolism, Год журнала: 2025, Номер unknown
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
2
International Immunopharmacology, Год журнала: 2025, Номер 147, С. 113953 - 113953
Опубликована: Янв. 13, 2025
Язык: Английский
Процитировано
0
International Journal of COPD, Год журнала: 2025, Номер Volume 20, С. 709 - 722
Опубликована: Март 1, 2025
Recently, numerous studies have explored the potential impact of gut microbiota on Chronic Obstructive Pulmonary Disease (COPD). However, causal relationship between skin and COPD, as well differences similarities relationships has not been thoroughly studied. We conducted a comprehensive two-sample Mendelian randomization (MR) analysis to investigate COPD. The inverse variance weighted (IVW) method was used primary approach. MR-Egger, median, MR-PRESSO methods were supplementary approaches. Various sensitivity stability analyses validate results. Genetic variations obtained from FR02 cohort study. derived KORA FF4 PopGen cohorts, with total 1,656 samples. GWAS data for COPD FinnGen consortium, including 18,266 cases 311,286 controls European cohorts. results IVW MR showed that 10 microbiotas 4 negatively associated [p < 0.05, odds ratio (OR) 1]; 3 6 positively (p OR > 1). None them heterogeneous or horizontally pleiotropic 0.05) reverse causality. This study revealed offering fresh perspectives prevention, diagnosis, management
Язык: Английский
Процитировано
0
Frontiers in Microbiology, Год журнала: 2024, Номер 15
Опубликована: Июль 16, 2024
Preclinical evidence has firmly established a bidirectional interaction among the lung, gut, and gut microbiome. There are many complex communication pathways between lung intestine, which affect each other's balance. Some metabolites produced by intestinal microorganisms, immune cells, factors enter tissue through blood circulation participate in function. Altered gut-lung-microbiome interactions have been identified rodent models humans of several diseases such as pulmonary fibrosis, chronic obstructive disease, cancer, asthma, etc. Emerging suggests that microbial therapies can prevent treat respiratory diseases, but it is unclear whether this association simple correlation with pathological mechanisms disease or result causation. In review, we summarize critical link microbiota well influence mechanism on discuss role interventions prebiotics fecal bacteria transplantation diseases. To provide reference for rational design large-scale clinical studies, direct application therapy to respiratory-related reduce incidence severity accompanying complications.
Язык: Английский
Процитировано
4
Children, Год журнала: 2025, Номер 12(3), С. 358 - 358
Опубликована: Март 14, 2025
Children diagnosed with cerebral palsy (CP) frequently face a range of intricate health challenges that go beyond their main condition. Respiratory problems represent one the most crucial factors contributing to morbidity and mortality. This review employed systematic approach identify collate recent findings on respiratory microbiota in children CP. The emphasizes notable microbial alterations systems CP, marked by decrease beneficial bacteria (such as Corynebacterium spp. Dolosigranulum spp.) an increase opportunistic pathogens like Staphylococcus aureus, Pseudomonas aeruginosa, Klebsiella pneumonia. These changes probably vulnerability CP frequent infections, ongoing inflammation, infections are resistant antibiotics. Key influencing composition include living urban areas, socioeconomic factors, seasonal variations, vaccination status, dietary habits, breastfeeding, etc. Although new research has shed significant light this topic, there still considerable gaps our understanding how these communities develop interact immune responses host. Future should focus longitudinal studies track over time interventions optimize
Язык: Английский
Процитировано
0
Advances in Microbiology, Год журнала: 2025, Номер 14(01), С. 45 - 51
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
0
Seminars in Fetal and Neonatal Medicine, Год журнала: 2025, Номер unknown, С. 101639 - 101639
Опубликована: Апрель 1, 2025
Язык: Английский
Процитировано
0
Frontiers in Cellular and Infection Microbiology, Год журнала: 2024, Номер 14
Опубликована: Сен. 20, 2024
Bronchopulmonary dysplasia (BPD) is a chronic lung disease that affects premature infants and leads to long-term pulmonary complications. The pathogenesis of BPD has not been fully elucidated yet. In recent years, the microbiome its metabolites, especially short-chain fatty acids (SCFAs), in gut lungs have demonstrated be involved development progression disease. This review aims summarize current knowledge on potential involvement SCFAs, latter, BPD. First, we introduce gut-lung axis, production functions role SCFAs health diseases. We then discuss evidence supporting Finally, elaborate mechanisms BPD, including immune modulation, epigenetic regulation, enhancement barrier function, modulation surfactant microbiome. could advance our understanding which also helps identify new therapeutic targets facilitate drug development.
Язык: Английский
Процитировано
2
Pathogens, Год журнала: 2024, Номер 13(11), С. 1005 - 1005
Опубликована: Ноя. 15, 2024
Recent advances in microbiome research have uncovered a dynamic and complex connection between the gut lungs, known as gut-lung axis. This bidirectional communication network plays critical role modulating immune responses maintaining respiratory health. Mediated by interactions, metabolic byproducts, microbial communities both organs, this axis demonstrates how gut-derived signals, such metabolites modulators, can reach lung tissue via systemic circulation, influencing function disease susceptibility. To explore implications of connection, we conducted systematic review studies published 2001 2024 (with much nearly 60% covering period 2020-2024), using keywords "gut-lung axis", "microbiome", "respiratory disease", "immune signaling". Studies were selected based on their relevance to mechanisms, impact dysbiosis, microbiota diseases. provides comprehensive overview axis, emphasizing its importance regulating inflammatory linked Understanding intricate pathway opens new avenues for microbiota-targeted therapeutic strategies, which could offer promising interventions diseases like asthma, chronic obstructive pulmonary disease, even infections. The insights gained through underscore potential novel target preventative approaches medicine, with enhancing
Язык: Английский
Процитировано
2
bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown
Опубликована: Ноя. 3, 2024
Abstract N -acyl lipids are important mediators of several biological processes including immune function and stress response. To enhance the detection with untargeted mass spectrometry-based metabolomics, we created a reference spectral library retrieving lipid patterns from 2,700 public datasets, identifying 851 that were detected 356,542 times. 777 not documented in structural databases, 18% these derived short-chain fatty acids found digestive tract other organs. Their levels varied diet, microbial colonization, people living diabetes. We used to link lipids, histamine polyamine conjugates, HIV status cognitive impairment. This resource will annotation compounds future studies further understanding their roles health disease highlight value large-scale metabolomics data for metabolite discovery.
Язык: Английский
Процитировано
1