Metabolomics Revealed Cadmium Exposure Associated with Alterations in Serum Metabolism in Children

Biological Trace Element Research, Год журнала: 2025, Номер unknown

Опубликована: Янв. 6, 2025

Язык: Английский

Nanometerizing Taxifolin Into Selenized Liposomes to Ameliorate Its Hypoglycemic Effect by Optimizing Drug Release and Bioavailability

International Journal of Nanomedicine, Год журнала: 2025, Номер Volume 20, С. 2225 - 2240

Опубликована: Фев. 1, 2025

Diabetes mellitus (DM) remains a significant health challenge, with traditional treatments often failing to provide lasting solutions. Taxifolin (Tax), potential phytomedicine antioxidant and anti-hyperglycemic properties, suffers from low water solubility poor bioavailability, necessitating advanced delivery systems. This study aims nanometerize taxifolin (Tax) into selenized liposomes (Tax-Se@LPs) for enhanced oral hypoglycemic effect. Tax-Se@LPs were fabricated through thin-film hydration/in situ reduction technique. The resulting nanomedicine was characterized in vitro release studies, pharmacokinetic pharmacodynamic evaluations, cellular uptake assays, formulation stability tests. optimized demonstrated an average particle size of 185.3 nm entrapment efficiency 95.25% after optimization. In studies revealed that exhibited slower more sustained profile compared conventional liposomes, favoring gastrointestinal drug absorption. Pharmacokinetic evaluations normal rats indicated achieved relative bioavailability 216.65%, significantly higher than Tax suspensions unmodified liposomes. Furthermore, diabetic GK rats, resulted maximal blood glucose 46.8% therapeutic duration other formulations. Cellular tests manifested selenization altered the internalization mechanisms while preserving their absorption aptness by intestinal epithelial cells. physiological also reinforced selenization. Overall, not only improve but enhance its efficacy. These findings underscore as promising strategy DM management.

Язык: Английский

Hepatoprotective potential of taxifolin in type 2 diabetic rats: modulation of oxidative stress and Bcl2/Bax/Caspase-3 signaling pathway

Molecular Biology Reports, Год журнала: 2024, Номер 51(1)

Опубликована: Авг. 8, 2024

Язык: Английский